Blood Transfusions in Dogs and Cats Receiving Hemodialysis: 230 Cases (June 1997–September 2012)

Langston, Catherine E.; Cook, Audrey K.; Eatroff, Adam; Mitelberg, Eleonora; Chalhoub, Serge

doi:10.1111/jvim.14658

Cited by 13 publications

(9 citation statements)

References 35 publications

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“…The main indication for transfusion in cats is anaemia; therefore, whole blood (WB) and packed red blood cell (PRBC) units are the most commonly collected and stored blood products. [1][2][3][4] WB is still extensively used in feline transfusion medicine, primarily reflecting the ease with which this blood component can be obtained. Although there are no legal standards for storage of feline WB (FWB) units for transfusion purposes, the length of storage is based on the criteria set by the US Food and Drug Administration…”

Section: Introductionmentioning

confidence: 99%

Haematological and morphological evaluation of feline whole blood units collected for transfusion purposes

Spada

Perego

Baggiani

et al. 2018

Journal of Feline Medicine and Surgery

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Objectives Despite the increasing availability of feline blood collected and stored for transfusion purposes, few studies have been performed on feline blood units. The aim of this prospective in vitro study was to evaluate haematological and morphological changes in feline blood cells in whole blood units between collection and end of storage. Methods Haematological examination (red blood cells [RBCs], haemoglobin, haematocrit, red cell distribution width, mean cell volume, mean cell haemoglobin concentration, mean cell haemoglobin, white blood cells [WBCs] and platelet [PLT] count) was performed on 40 non-leukoreduced feline whole blood units at time of collection (day[D]0) and after storage (D35). The blood was collected into citrate-phosphate-dextrose-adenine anticoagulant-preservative solution using an open system in a veterinary blood bank and stored for 35 days at 4 ± 2°C. Twenty of these feline whole blood units were also analysed for blood cell morphology (normal RBCs, macrocytes, echinocytes, spherocytes, schistocytes, lysed RBCs, RBCs with Heinz bodies and recognisable WBC and PLT count). Differences between the two examination times were statistically analysed. Results There was a statistically significant decrease in WBC and PLT counts after storage at D35 ( P <0.0001 for both). The most significant cellular morphological change after storage was an increase in echinocyte count ( P = 0.0001), and lysed RBCs ( P <0.0001), and a decrease in normal RBCs ( P <0.0001). Recognisable WBCs - mainly lymphocytes - were present at the end of storage. Conclusions and relevance This study showed that significant morphological changes occur in RBCs in feline blood units during storage for 35 days. In vivo studies are required to establish if these changes could affect the ability of stored RBCs to circulate and provide adequate oxygen delivery after transfusion.

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Section: Introductionmentioning

confidence: 99%

Haematological and morphological evaluation of feline whole blood units collected for transfusion purposes

Spada

Perego

Baggiani

et al. 2018

Journal of Feline Medicine and Surgery

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“…Comparisons between groups revealed slightly lower platelet count values in HDG than in CG, with a statistically significant reduction observed in HDG on Day 2 (Table 2). As cited above, clotting in the extracorporeal circuit and dialyzer can reduce the number of platelets; likewise, uremic thrombocytopathy may also contribute to platelet loss (LANGSTON et al, 2017).…”

Section: Resultsmentioning

confidence: 97%

“…Dogs submitted to IHD may develop anemia due to the dialyzer type, excessive negative access pressure, repeated blood sampling, and circuit clotting. Furthermore, prolonged anticoagulation can induce or exacerbate bleeding; hemolysis can also occur due to contaminants in the water supply, hypotonic or overheated dialysate, and extracorporeal circuit tubing problems (LANGSTON et al, 2017). In contrast, although there was a small reduction of RBC in CG dogs at the end of fluid therapy treatment, it was not statistically significant, demonstrating that fluid therapy does not increase anemia in patients with CKD.…”

Section: Resultsmentioning

confidence: 99%

“…Multiple factors contribute to anemia in dogs receiving hemodialysis (LANGSTON et al, 2017). Hematological evaluation of the red blood cells (RBC), hematocrit (Ht), and hemoglobin (Hb) in CG dogs showed reduced values in the POST samples from Days 1 to 8 and Day 15, but only the Ht and Hb values from Day 8 were statistically significant (Table 1).…”

Section: Resultsmentioning

confidence: 99%

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Intermittent hemodialysis in dogs with chronic kidney disease stage III

et al. 2017

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Intermittent hemodialysis (IHD) is a form of renal replacement that is used in veterinary medicine for cases involving drug removal, electrolyte imbalance, acute kidney injury, and chronic kidney disease (CKD). The aim of the present study was to verify the efficacy of IHD in dogs with CKD staged at grade III and to evaluate the effect of IHD on quality of life. Twelve dogs with CKD at stage III met the inclusion criteria and were divided equally into two groups. The control group (n=6) received only clinical treatment and intravenous fluid therapy, and the hemodialysis group (n=6) received clinical and IHD treatments. Blood samples were collected before and after treatments in both groups. We evaluated complications and clinical parameters of IHD every 30 minutes. Hemodialysis decreased serum urea, creatinine, and phosphorus. Despite the evident removal of nitrogen compounds, dialysis treatment did not increase survival time in these patients. The results of this study do not support the early use of dialysis in dogs with chronic kidney disease stage III.

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“…Conversely, in veterinary medicine, despite the knowledge of blood storage alterations in different species, such control measures are not well established 9 . In dogs and cats, and even in horses, transfusion medicine has become more advanced with varied protocols and uses for blood products 10‐13 . Moreover, in ruminants, hemotherapy is generally limited to whole blood transfusions 14,15 .…”

Section: Introductionmentioning

confidence: 99%

Impact of blood storage duration on hematologic, blood gas, biochemical, and oxidative stress variables in sheep undergoing allogeneic blood transfusions

Sousa

Minervino

Oliveira

et al. 2020

Veterinary Clinical Pathol

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BackgroundHemotherapy in ruminants is limited to whole blood transfusions, sometimes with stored blood for up to 42 days, but little attention has been given to the effect of blood storage times and recipient responses after transfusions.ObjectivesWe aimed to evaluate the hematologic and serum biochemical effects after allogeneic blood transfusion with either fresh or stored blood in sheep. We also sought to examine hematologic and biochemical analyte changes in the store blood.MethodsEighteen sheep underwent a single phlebotomy to remove 40% of their blood volume. The sheep were divided into three experimental groups, G0, G15, and G35, which included six animals, each receiving 20 mL/kg of either fresh blood or blood stored in citrate, phosphate, dextrose, and adenine (CPDA‐1) bags for 15 and 35 days, respectively. Biochemical, hematologic, coagulation, blood gas, lipid peroxidation, and oxidative stress test evaluations were performed using the blood samples gathered at T0 (before transfusion), 30 minutes (T30m), 6, 12, 24, 48, 72, and 96 hours (T6h‐T96h), 8 days (T8d), and 16 days (T16d) after transfusions.ResultsSheep exhibited increases in packed cell volumes, red blood cell counts, and total hemoglobin concentrations at T30m (P < .05). G35 animals had greater plasma hemoglobin concentrations at T12h and decreased blood pH values at T6h, characterized by slight metabolic acidemia. Regarding oxidative stress, G35 animals had decreased catalase activities from T0 at T30m, T6h, T12h, and T24h, indicating that hemolysis had occurred, which was supported by concomitant increases in bilirubin.ConclusionsSheep transfused with 35‐day stored blood exhibited greater hematologic, blood gas, biochemical, and oxidative alterations; however, anemic animals without comorbidities effectively reversed those alterations.

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Blood Transfusions in Dogs and Cats Receiving Hemodialysis: 230 Cases (June 1997–September 2012)

Cited by 13 publications

References 35 publications

Haematological and morphological evaluation of feline whole blood units collected for transfusion purposes

Haematological and morphological evaluation of feline whole blood units collected for transfusion purposes

Intermittent hemodialysis in dogs with chronic kidney disease stage III

Impact of blood storage duration on hematologic, blood gas, biochemical, and oxidative stress variables in sheep undergoing allogeneic blood transfusions

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