Blood vessel formation and function in bone

Sivaraj, Kishor K.; Adams, Ralf H.

doi:10.1242/dev.136861

Cited by 364 publications

(340 citation statements)

References 131 publications

(139 reference statements)

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“…The hypertrophic chondrocytes also secrete ibroblast growth factor (FGF), bone morphogenetic protein (BMP) and connective tissue growth factor (CTGF) [2,3]. With the arrival of these factors to the site of bone formation, angiogenesis in the bone can now occur.…”

Section: Angiogenesis During Formation Of the Cartilage Templatementioning

confidence: 99%

“…There is a complex cross talk between bone-forming cells (osteoblasts), the angiogenic factors present, and the invading vasculature. These growth factors, in particular VEGF, recruit osteo/chondro-clasts, osteoprogenitors and other bone precursors to the area in order to initiate the primary ossiication center, the irst site of bone formation within the cartilage template [2,4].…”

Section: Angiogenesis During Formation Of the Cartilage Templatementioning

confidence: 99%

“…Osteoclasts are bone matrix resorbing cells, and once recruited, they secrete multiple factors that contribute to the initiation of vascularization, including the release of more VEGF and FGFs [2,5]. Among these factors are matrix metalloproteinases (MMPs) and hypoxia-inducible factors (HIFs) which, along with VEGF, are other key proteins important in the development of vasculature in bone.…”

Section: Angiogenesis During Formation Of the Cartilage Templatementioning

confidence: 99%

“…The MMPs break down the ECM and release matrix-bound VEGF that allows for the resorption of cartilage so that osteoblasts can iniltrate and deposit bone. MMPs, primarily MMP9 and MMP13, also function to recruit osteoclasts and osteoprogenitors, further aiding in the subsequent deposition of bone [2,4]. The matrix-bound VEGF that is released is a key player in the formation of bone vasculature.…”

Section: Angiogenesis During Formation Of the Cartilage Templatementioning

confidence: 99%

“…The matrix-bound VEGF that is released is a key player in the formation of bone vasculature. HIFs regulate VEGF Physiologic and Pathologic Angiogenesis -Signaling Mechanisms and Targeted Therapyexpression in bone, which has an efect on angiogenesis [2]. Thus VEGF, MMPs and HIFs play a central role in angiogenesis during endochondral ossiication.…”

Section: Angiogenesis During Formation Of the Cartilage Templatementioning

confidence: 99%

See 4 more Smart Citations

Angiogenesis Meets Skeletogenesis: The Cross-Talk between Two Dynamic Systems

Franz‐Odendaal¹,

Andrews²,

Kumar³

2017

Physiologic and Pathologic Angiogenesis - Signaling Mechanisms and Targeted Therapy

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In this chapter, we describe the complex relationship between angiogenesis and skeletogenesis. While much is known about the interactions of these two dynamic systems for bones that ossify via a cartilage template, comparatively litle is known about directly ossifying bones. Most of the bones of the head develop from osteogenic condensations and undergo intramembranous (direct) ossiication during development. Our understanding of the relationship between osteogenic cell condensations (in particular) and angiogenesis is currently inadequate and prevents a comprehensive understanding of vertebrate head development. This chapter highlights our understanding of both direct and indirectly ossifying bones shedding light on where there are important gaps in our understanding.

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Section: Angiogenesis During Formation Of the Cartilage Templatementioning

confidence: 99%

Section: Angiogenesis During Formation Of the Cartilage Templatementioning

confidence: 99%

Section: Angiogenesis During Formation Of the Cartilage Templatementioning

confidence: 99%

Section: Angiogenesis During Formation Of the Cartilage Templatementioning

confidence: 99%

Section: Angiogenesis During Formation Of the Cartilage Templatementioning

confidence: 99%

See 3 more Smart Citations

Angiogenesis Meets Skeletogenesis: The Cross-Talk between Two Dynamic Systems

Franz‐Odendaal¹,

Andrews²,

Kumar³

2017

Physiologic and Pathologic Angiogenesis - Signaling Mechanisms and Targeted Therapy

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From Arteries to Capillaries: Approaches to Engineering Human Vasculature

Fleischer

Tavakol

Vunjak-Novakovic

2020

Adv Funct Materials

111

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From microscaled capillaries to millimeter‐sized vessels, human vasculature spans multiple scales and cell types. The convergence of bioengineering, materials science, and stem cell biology has enabled tissue engineers to recreate the structure and function of different hierarchical levels of the vascular tree. Engineering large‐scale vessels aims to replace damaged arteries, arterioles, and venules and their routine application in the clinic may become a reality in the near future. Strategies to engineer meso‐ and microvasculature are extensively explored to generate models for studying vascular biology, drug transport, and disease progression as well as for vascularizing engineered tissues for regenerative medicine. However, bioengineering tissues for transplantation has failed to result in clinical translation due to the lack of proper integrated vasculature for effective oxygen and nutrient delivery. The development of strategies to generate multiscale vascular networks and their direct anastomosis to host vasculature would greatly benefit this formidable goal. In this review, design considerations and technologies for engineering millimeter‐, meso‐, and microscale vessels are discussed. Examples of recent state‐of‐the‐art strategies to engineer multiscale vasculature are also provided. Finally, key challenges limiting the translation of vascularized tissues are identified and perspectives on future directions for exploration are presented.

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Inorganic Agents for Enhanced Angiogenesis of Orthopedic Biomaterials

Šalandová

Hengel

Apachitei

et al. 2021

Adv Healthcare Materials

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Aseptic loosening of a permanent prosthesis remains one of the most common reasons for bone implant failure. To improve the fixation between implant and bone tissue as well as enhance blood vessel formation, bioactive agents are incorporated into the surface of the biomaterial. This study reviews and compares five bioactive elements (copper, magnesium, silicon, strontium, and zinc) with respect to their effect on the angiogenic behavior of endothelial cells (ECs) when incorporated on the surface of biomaterials. Moreover, it provides an overview of the state-of-the-art methodologies used for the in vitro assessment of the angiogenic properties of these elements. Two databases are searched using keywords containing ECs and copper, magnesium, silicon, strontium, and zinc. After applying the defined inclusion and exclusion criteria, 59 articles are retained for the final assessment. An overview of the angiogenic properties of five bioactive elements and the methods used for assessment of their in vitro angiogenic potential is presented. The findings show that silicon and strontium can effectively enhance osseointegration through the simultaneous promotion of both angiogenesis and osteogenesis. Therefore, their integration onto the surface of biomaterials can ultimately decrease the incidence of implant failure due to aseptic loosening.

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Blood vessel formation and function in bone

Cited by 364 publications

References 131 publications

Angiogenesis Meets Skeletogenesis: The Cross-Talk between Two Dynamic Systems

Angiogenesis Meets Skeletogenesis: The Cross-Talk between Two Dynamic Systems

From Arteries to Capillaries: Approaches to Engineering Human Vasculature

Inorganic Agents for Enhanced Angiogenesis of Orthopedic Biomaterials

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