Blood Viscosity and Raynaud's Disease

Pringle, R.; Walder, D. N.; Weaver, Joe

doi:10.1016/s0140-6736(65)92673-5

Cited by 72 publications

(16 citation statements)

References 9 publications

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“…Many studies have examined the association between hemostatic factors and blood viscosity with RP with conflicting results [41][42][43][44][45][46][47][48][49][50][51]. Most of these studies were based on small numbers of patients [41,42,44,45,47,49] and did not adjust for potential confounders [41,42,46,50].…”

Section: Hemostatic Factorsmentioning

confidence: 99%

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Raynaud’s phenomenon: Epidemiology and risk factors

Fraenkel

2002

Curr Rheumatol Rep

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Although originally described more than 100 years ago, the pathophysiology of Raynaud's phenomenon (RP) remains incompletely understood. Epidemiologic studies have the potential to improve our understanding of the pathogenesis of RP and to identify potential targets for therapeutic interventions. Such studies require standardized instruments to accurately identify subjects with RP. Dr. Maricq was the first to develop and validate a standardized instrument to classify patients with this disorder. Her work has facilitated many of the epidemiologic studies of RP that are discussed in this review.

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Section: Hemostatic Factorsmentioning

confidence: 99%

“…Most of these studies were based on small numbers of patients [41,42,44,45,47,49] and did not adjust for potential confounders [41,42,46,50]. Fraenkel et al [51] tried to avoid some of these limitations by examining hemostatic factors in a large, community-based sample.…”

Section: Hemostatic Factorsmentioning

confidence: 99%

Raynaud’s phenomenon: Epidemiology and risk factors

Fraenkel

2002

Curr Rheumatol Rep

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“…Pringle et al (21) found that patients with Raynaud's disease tended to have a significantly higher blood viscosity compared to those patients without Raynaud's disease. Kim et al (22) found that increased blood viscosity would decrease pulpal blood flow.…”

Section: Discussionmentioning

confidence: 99%

A Case Report of a Patient with Raynaud’s Phenomenon Undergoing Multiple Endodontic Procedures

Rankin

2007

Journal of Endodontics

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“…Raynaud's phenomenon may be a precursor to more serious, possibly fatal diseases such as scleroderma, systemic lupus erythematosus, rheumatoid arthritis and vasculitis [2]. Several factors contribute to the pathogenesis of Raynaud's phenomenon and alterations in the haemostatic system were documented in patients with PRP [1,[3][4][5]. Endothelial damage and/or thrombosis in the digits could be part of PRP etiology [6].…”

Section: Introductionmentioning

confidence: 99%

Polymorphism of clotting factors in Hungarian patients with Raynaud's phenomenon

Shemirani¹,

Szomják²,

Balogh³

et al. 2011

Blood Coagulation &Amp; Fibrinolysis

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Patients with primary Raynaud's phenomenon may have a genetically determined risk for clotting factors that predispose them to aberrant microvascular thrombosis. We investigated the prevalence of factor V substitution of G to A at position 1691 (FVLeiden), prothrombin G20210A, and methyltetrahydrofolate reductase C677T mutations in these patients. Two hundred (158 women, 42 men, mean age of 42.4 ± 13.7 years) consecutive patients with primary Raynaud's phenomenon and 200 age-sex-matched healthy controls of Hungarian origin were included in a case-control study. The prevalence of methyltetrahydrofolate reductase C677T homozygous among patients was significantly lower than in the control group (odds ratio 0.4, 95% confidence interval 0.2-0.9, P < 0.05). The prevalence of other thrombosis-associated alleles did not differ between patients with primary Raynaud's phenomenon and control subjects. FVLeiden, prothrombin G20210A, and polymorphism, prothrombin G20210A mutations have no apparent effect on the etiology of primary Raynaud's phenomenon.

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Blood Viscosity and Raynaud's Disease

Cited by 72 publications

References 9 publications

Raynaud’s phenomenon: Epidemiology and risk factors

Raynaud’s phenomenon: Epidemiology and risk factors

A Case Report of a Patient with Raynaud’s Phenomenon Undergoing Multiple Endodontic Procedures

Polymorphism of clotting factors in Hungarian patients with Raynaud's phenomenon

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