Blood viscosity but not shear stress associates with delayed flow-mediated dilation

Irace, Concetta; Tripolino, Cesare; Scavelli, Faustina; Messiniti, Valentina; Tassone, Bruno; Valle, Elisabetta Della; Carallo, Claudio; Gnasso, Agostino

doi:10.1007/s00421-014-3058-8

Cited by 7 publications

(7 citation statements)

References 27 publications

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“…Brachial artery SS and blood viscosity are crucial not only for the magnitude but also for the timing of vasodilation. 19,20 Very often, the vasodilatory response is evaluated only in the first 50-60 s after cuff deflation. This approach is limiting because some subjects dilate after 1 min.…”

Section: Discussionmentioning

confidence: 99%

Effect of empagliflozin on brachial artery shear stress and endothelial function in subjects with type 2 diabetes: Results from an exploratory study

Irace

Cutruzzolà

Parise

et al. 2019

Diabetes and Vascular Disease Research

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Empagliflozin reduces the risk of cardiovascular mortality in subjects with type 2 diabetes. We demonstrated that empagliflozin increases blood viscosity and carotid shear stress and decreases carotid wall thickness. Shear stress is the force acting on the endothelial surface and modulates arterial function. The current study evaluates the influence of empagliflozin on brachial artery shear stress and endothelial function compared to incretin-based therapy. The study is a nonrandomized, open, prospective cohort study including 35 subjects with type 2 diabetes administered empagliflozin or incretin-based therapy. Shear stress was calculated with a validated formula, and endothelial function was evaluated using the flow-mediated dilation technique. Both treatments resulted in comparable reductions in blood glucose and glycated haemoglobin. Brachial artery shear stress significantly increased exclusively in the empagliflozin group (61 ± 20 vs 68 ± 25 dynes/cm2, p = 0.04), whereas no significant difference was detected in the incretin-based therapy group (60 ± 20 vs 55 ± 12 dynes/cm2, p = not significant). Flow-mediated dilation significantly increased in the empagliflozin group (4.8 ± 4.5% vs 8.5 ± 5.6%, p = 0.03). Again, no change was detected in the incretin-based therapy group (5.1 ± 4.5% vs 4.7 ± 4.7%, p = not significant). The present findings demonstrate the beneficial effect of empagliflozin on shear stress and endothelial function in subjects with type 2 diabetes independent of the hypoglycaemic effect.

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Section: Discussionmentioning

confidence: 99%

Effect of empagliflozin on brachial artery shear stress and endothelial function in subjects with type 2 diabetes: Results from an exploratory study

Irace

Cutruzzolà

Parise

et al. 2019

Diabetes and Vascular Disease Research

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“…Based on the time to peak, dilation subjects were defined as ‘early dilators’ if peak FMD was at 50 s; ‘late dilators’ if peak FMD was >50 s. ‘No dilators’ were defined as those subjects who did not dilate at all during the observation points 13-15. The reproducibility of the method has been published elsewhere 25. Briefly, the coefficient of variation of FMD was 7.4 per cent, the FMD technical error of measurement (TEM) was 0.55, and the % TEM was 6.7 per cent.…”

Section: Methodsmentioning

confidence: 99%

Delayed Flow-Mediated Vasodilation and Critical Coronary Stenosis

Irace

Rosa

Tripolino

et al. 2018

Journal of Investigative Medicine

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Endothelial dysfunction, wall thickening and plaque are progressive manifestations of atherosclerosis. Delayed or absent brachial artery dilation after ischemic stimulus has been associated with severity of extracoronary and coronary atherosclerosis. In the current study, we aimed to verify if delayed or absent dilation associates with critical coronary stenosis. We also evaluated the association between coronary stenosis, carotid artery wall thickness and peripheral artery disease. Endothelial function was investigated by flow-mediated dilation of the brachial artery up to 3 min after ischemia, and patients classified as early, late or no dilators. Coronary angiography was performed through transradial or femoral artery approach. Computerized quantitative angiography was used to obtain percent stenosis of all lesions, while the Gensini score was used to evaluate the severity of coronary atherosclerosis. Seventy-four patients were enrolled. Carotid wall thickness and plaque, and peripheral artery disease were detected by ultrasound. Subjects with critical coronary stenosis showed a higher prevalence of delayed or absent dilation (coronary stenosis ≥70 per cent: late dilators 50 per cent, no dilators 35 per cent; coronary stenosis ≤70 per cent : late dilators 27 per cent, no dilators 6 per cent). The Gensini score was progressively higher in late dilators and no dilators compared with early dilators (early: 4.5±13.5; late 17.5±27.1; no 39.7±55.0; P<0.02). Carotid atherosclerosis and peripheral artery disease were more prevalent in subjects with critical coronary stenosis. Delayed or absent dilation associates with coronary stenosis and different degree of coronary atherosclerosis. The kinetic of arterial dilation seems to be relevant as the magnitude of dilation.

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“…Evaluation methods for vascular endothelial function have been extensively studied since the 1980s, and the first attempt involved invasive methods 5–9 . For example, Panza et al .…”

Section: Introductionmentioning

confidence: 99%

“…In addition, evaluation methods focusing on the arterial mechanical characteristics have been attracted attention since the 2000s 5–9 because it is a rather direct measure of vasodilation compared to the vascular diameter, which can be affected by changes in the blood pressure. In these studies, several measures such as the pulse wave velocity were used to evaluate the arterial stiffness or viscoelasticity.…”

Section: Introductionmentioning

confidence: 99%

Estimation of Arterial Viscosity Based on an Oscillometric Method and Its Application in Evaluating the Vascular Endothelial Function

Tanaka

Mito

Hirano

et al. 2019

Sci Rep

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This paper proposes an algorithm for estimating the arterial viscosity using cuff pressures and pulse waves measured by an automatic oscillometric sphygmomanometer. A change in the arterial viscosity during the enclosed-zone flow-mediated dilation test is calculated as an index for evaluating the vascular endothelial function % η . In all, 43 individuals participated in this study. After the index % η was calculated, the accuracy of the index % η in distinguishing healthy subjects and subjects at a high risk of arteriosclerosis was tested via a receiving operating characteristic (ROC) analysis. The calculated % η for the healthy participants and those at a high risk of arteriosclerosis was 13.4 ± 55.1% and −32.7 ± 34.0% (mean ± S.D.), respectively. The area under the ROC curve was 0.77. Thus, it was concluded that the proposed method can be used to evaluate the vascular endothelial function.

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Blood viscosity but not shear stress associates with delayed flow-mediated dilation

Abstract: The present study demonstrates that age and blood viscosity but not the magnitude of SS explain the different timing of the dilatory response to ischemia.

Cited by 7 publications

References 27 publications

Effect of empagliflozin on brachial artery shear stress and endothelial function in subjects with type 2 diabetes: Results from an exploratory study

Effect of empagliflozin on brachial artery shear stress and endothelial function in subjects with type 2 diabetes: Results from an exploratory study

Delayed Flow-Mediated Vasodilation and Critical Coronary Stenosis

Estimation of Arterial Viscosity Based on an Oscillometric Method and Its Application in Evaluating the Vascular Endothelial Function

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