Estimation of Arterial Viscosity Based on an Oscillometric Method and Its Application in Evaluating the Vascular Endothelial Function

Tanaka, Hiroshi; Mito, Akihisa; Hirano, Hirohiko; Soh, Zu; Nakamura, Ryuji; Saeki, Noboru; Kawamoto, Masashi; Higashi, Yukihito; Yoshizumi, Masao; Tsuji, Toshio

doi:10.1038/s41598-019-38776-4

Cited by 3 publications

(3 citation statements)

References 31 publications

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“…In this study, participants were restricted to young men. Considering that our previous study indicated that ageing affects the mechanical characteristics of arteries 23 , the lack of analysis on the age and sex could be limitations of this paper.…”

Section: Discussionmentioning

confidence: 98%

Peripheral arterial stiffness during electrocutaneous stimulation is positively correlated with pain-related brain activity and subjective pain intensity: an fMRI study

Tsuji

Arikuni

Sasaoka

et al. 2021

Sci Rep

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Brain activity associated with pain perception has been revealed by numerous PET and fMRI studies over the past few decades. These findings helped to establish the concept of the pain matrix, which is the distributed brain networks that demonstrate pain-specific cortical activities. We previously found that peripheral arterial stiffness $${\beta }_{\text{art}}$$ β art responds to pain intensity, which is estimated from electrocardiography, continuous sphygmomanometer, and photo-plethysmography. However, it remains unclear whether and to what extent $${\beta }_{\text{art}}$$ β art aligns with pain matrix brain activity. In this fMRI study, 22 participants received different intensities of pain stimuli. We identified brain regions in which the blood oxygen level-dependent signal covaried with $${\beta }_{\text{art}}$$ β art using parametric modulation analysis. Among the identified brain regions, the lateral and medial prefrontal cortex and ventral and dorsal anterior cingulate cortex were consistent with the pain matrix. We found moderate correlations between the average activities in these regions and $${\beta }_{\text{art}}$$ β art (r = 0.47, p < 0.001). $${\beta }_{\text{art}}$$ β art was also significantly correlated with self-reported pain intensity (r = 0.44, p < 0.001) and applied pain intensity (r = 0.43, p < 0.001). Our results indicate that $${\beta }_{\text{art}}$$ β art is positively correlated with pain-related brain activity and subjective pain intensity. This study may thus represent a basis for adopting peripheral arterial stiffness as an objective pain evaluation metric.

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Section: Discussionmentioning

confidence: 98%

Peripheral arterial stiffness during electrocutaneous stimulation is positively correlated with pain-related brain activity and subjective pain intensity: an fMRI study

Tsuji

Arikuni

Sasaoka

et al. 2021

Sci Rep

Self Cite

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“…BP serves as a crucial physiological parameter as it provides insights into heart health, organ perfusion, and the overall hemodynamic stability of an individual. [1][2][3] Elevated BP or hypertension poses signicant risks to human health as it is a prominent contributor to cardiovascular diseases, organ failure, and stroke. [5][6][7] Cardiovascular disease and the associated complications are considered the leading causes of death worldwide, claiming approximately 18 million lives in 2019 and accounting for nearly one-third of all fatalities.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of blood pressure using a flexible and wearable capacitive pressure sensor

Bijender,

Kumar,

Soni

et al. 2023

RSC Adv.

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“…Previous studies regarding oscillometric signals have focused on either the modeling of the blood pressure measurement process [22][23][24][25][26] or the simple hardware simulator that can calibrate an automatic sphygmomanometer [27][28][29][30] to improve automatic sphygmomanometer accuracy. Some research has used the oscillometric signal to investigate cardiovascular-related parameters such as vascular endothelial function 2 . However, as far as we know, no previous work has investigated oscillometric signals with use of a cardiovascular simulator and phantoms with the aim of analyzing the correlation between oscillometric signals and cardiovascular-related parameters.…”

mentioning

confidence: 99%

Correlation analysis of human upper arm parameters to oscillometric signal in automatic blood pressure measurement

Jeong

Hong

Park

2022

Sci Rep

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Cardiovascular diseases are the leading cause of global deaths, making cardiovascular health monitoring important. Measuring blood pressure using an automatic sphygmomanometer is the most widely used method to monitor cardiovascular health due to its accessibility, convenience, and strong correlation with cardiovascular diseases. In this work, in order to estimate brachial artery diameter, stiffness, or thickness using an automatic sphygmomanometer, the correlation between upper arm parameters and the oscillometric signal was intensively investigated through analytical, numerical, and experimental approaches. The parametric studies commonly revealed that the inner radius of the brachial artery is the most influential parameter in determining the amplitude of the oscillometric signal. The experimental results of using a cardiovascular simulator (a virtual patient) combined with upper arm phantoms with various inner radii of the brachial artery showed a 6.5% change in the oscillometric signal amplitude with a 10% artery radius variation. It was concluded that the oscillometric signal can be used to evaluate brachial artery diameter. Based on the clinical relationship between brachial artery diameter and cardiovascular risk factors such as hypertension, diabetes, and obesity, this study showed and verified a novel method to monitor brachial artery diameter and hence, cardiovascular risks while measuring blood pressure.

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Estimation of Arterial Viscosity Based on an Oscillometric Method and Its Application in Evaluating the Vascular Endothelial Function

Cited by 3 publications

References 31 publications

Peripheral arterial stiffness during electrocutaneous stimulation is positively correlated with pain-related brain activity and subjective pain intensity: an fMRI study

Peripheral arterial stiffness during electrocutaneous stimulation is positively correlated with pain-related brain activity and subjective pain intensity: an fMRI study

Evaluation of blood pressure using a flexible and wearable capacitive pressure sensor

Correlation analysis of human upper arm parameters to oscillometric signal in automatic blood pressure measurement

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