Blood Volume Alterations in Congestive Heart Failure

Abstract

A considerable body of data indicates that the plasma volume, as measured by dye dilution methods, is generally increased in congestive heart failure (1-4). However, recent investigations, utilizing p82 (5, 6) or Cr51 (7)

Iron and Protein Kinetics Studied by Means of Doubly Labeled Human Crystalline Transferrin*

“…No significant difference was noted in the four preparations used. Plasma volumes obtained by extrapolating iodine counts to zero time were likewise similar to those obtained by others when radioalbumin was used (40). Indeed, in two subjects Evans blue plasma volume determinations were within 8 per cent of the isotope dilution volumes.…”

Blood Volume in Congestive Heart Failure1

“…Schreiber, Bauman, Yalow, and Berson (6) have reported that the mean ratio of body to venous hematocrit is .937 in control patients, .868 in patients with congestive heart failure, and .908 in patients free of failure. These differences in ratio imply that, where a tagged red cell method is used to determine total blood volume, comparisons between control patients, cardiac patients in congestive heart failure, and cardiac patients in the compensated state would be in error.…”

Change in Relationship of Blood Volume to Weight in Congestive Heart Failure

“…Two of the patients had received meralluride (Meeuhydrin) 3 and 12 hours before the study. Three of the failure patients were female whereas all of the control patients were male.…”