Blood warming in trauma related transfusions-Precepts and practices

Ghosh, Indrani; Haldar, Rudrashish

doi:10.17352/2455-2976.000101

Cited by 7 publications

(2 citation statements)

References 28 publications

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“…Indeed, Gentilello et al (13) found that while 6 U (or 2 liters) of packed cells can reduce core body temperature by approximately 1°C, 10 U of packed cells can yield a drop of up to 3°C in core temperature. Indrani and Rudrashish (14) showed that infusion of 3 liters of packed cells caused a significant drop in core temperature and increased the number of cardiac arrests.…”

Section: Introductionmentioning

confidence: 99%

Body Temperature Variation After Packed Cell Transfusion in Adult Patients With Sepsis—where Will the Pendulum Stop?

Klein¹,

Hassan

Binyamin

et al. 2023

Shock

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Background: Critically ill patients with sepsis often require packed cell transfusions (PCTs). Packed cell transfusion causes changes in body's core temperature. Objective: To trace the course and amplitude of body core temperature after PCT in adults with sepsis. Methods: We conducted a population-based retrospective cohort study of patients with sepsis who received one unit of PCT during their hospitalization in a general intensive care unit during 2000-2019. A control group was established by matching each of these patients to a patient who did not receive PCT. We calculated the mean values of urinary bladder temperature for the 24 h before and 24 h after PCT. To evaluate the effect of PCT on body core temperature, multivariable analyses using a mixed linear regression model were performed. Results: The study comprised 1,100 patients who received one unit of PCT and 1,100 matched patients. The mean temperature before PCT was 37.3°C. Immediately from initiation of PCT, body temperature decreased, to a minimum of 37.0°C. During the 24 subsequent hours, the temperature increased gradually and consistently, until a peak temperature of 37.4°C. In a linear regression model, body core temperature increased by a mean 0.06°C in the first 24 h after PCT and decreased by a mean 0.65°C for every 1.0°C increase before PCT. Conclusions: Among critically ill patients with sepsis, PCT itself causes only mild and clinically insignificant temperature changes. Thus, significant changes in core temperature during the 24 h after PCT may indicate an unusual clinical event that requires clinicians' immediate attention.

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Section: Introductionmentioning

confidence: 99%

Body Temperature Variation After Packed Cell Transfusion in Adult Patients With Sepsis—where Will the Pendulum Stop?

Klein¹,

Hassan

Binyamin

et al. 2023

Shock

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“…The effects of cold temperatures on blood cells has been extensively studied in blood transfusion medicine. [32,33] , [34] RBC morphology changes during rapid temperature decreases, which results in rouleaux formation and sludging related to cold agglutinins, cryoprecipitates, and/or cold reactive antibodies which can cause microvascular obstruction. [17,35] Similarly, platelets undergo activation-like effects when exposed to cold, which can result in platelet adhesion to the endothelium of the capillaries where tissue factor is exposed during endothelial trauma.…”

Section: Discussionmentioning

confidence: 99%

The effect of blood cells retained in rat livers during static cold storage on viability outcomes during normothermic machine perfusion

Haque

Pendexter

Wilks

et al. 2021

Preprint

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In transplantation, livers are transported to recipients using static cold storage (SCS), whereby livers are exposed to cold ischemic injury that contribute to post-transplant risk factors. We hypothesized that flushing organs during procurement with cold preservation solutions could influence the number of donor blood cells retained in the allograft thereby exacerbating cold ischemic injury. We present the results of rat livers that underwent 24h SCS after being flushed with a cold University of Wisconsin (UW) solution versus room temperature (RT) lactated ringers (LR) solution. These results were compared to livers that were not flushed prior to SCS and thoroughly flushed livers without SCS. We used viability and injury metrics collected during normothermic machine perfusion (NMP) and the number of retained peripheral cells (RPCs) measured by histology to compare outcomes. Compared to the cold UW flush group, livers flushed with RT LR had lower resistance, lactate, AST, and ALT at 6 hours of NMP. The number of RPCs also had significant positive correlations with resistance, lactate, and potassium levels and a negative correlation with energy charge. In conclusion, livers exposed to cold UW flush prior to SCS appear to perform worse during NMP, compared to RT LR flush.

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Complications Related to Blood Products

Tyagi

Mahajan

2022

Transfusion Practice in Clinical Neurosciences

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Blood warming in trauma related transfusions-Precepts and practices

Abstract: Stored blood at low temperature when transfused to patients of trauma can cause hypothermia leading to derangement of various systems and increased mortality. Therefore adequate warming of blood using different available techniques and equipments is essential prior to transfusion

Cited by 7 publications

References 28 publications

Body Temperature Variation After Packed Cell Transfusion in Adult Patients With Sepsis—where Will the Pendulum Stop?

Body Temperature Variation After Packed Cell Transfusion in Adult Patients With Sepsis—where Will the Pendulum Stop?

The effect of blood cells retained in rat livers during static cold storage on viability outcomes during normothermic machine perfusion

Complications Related to Blood Products

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