Bloodstream Infection and Endocarditis

Seifert, Harald; Wisplinghoff, Hilmar

doi:10.1002/9780470688618.taw0019

Cited by 12 publications

(12 citation statements)

References 560 publications

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“…Timely diagnosis and appropriate antimicrobial therapy have a major role in predicting the outcome of these infections. [ 1 ]…”

Section: Introductionmentioning

confidence: 99%

“…The usage of single blood culture, as well as more than three blood cultures, is highly discouraged. [ 1 ] Despite the fact that newer blood culture media and improved continuous monitoring blood culture systems detect organisms faster and more frequently, the volume of blood and a number of samples remain as major variables predicting the outcome of these culture systems.…”

Section: Introductionmentioning

confidence: 99%

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Comparative evaluation of the role of single and multiple blood specimens in the outcome of blood cultures using BacT/ALERT 3D (automated) blood culture system in a tertiary care hospital

Elantamilan

Lyngdoh

Khyriem

et al. 2016

Indian J Crit Care Med

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Introduction:Bloodstream infection (BSI) is a leading cause of mortality in critically ill patients. The mortality directly attributable to BSI has been estimated to be around 16% and 40% in general hospital population and Intensive Care Unit (ICU) population, respectively. The detection rate of these infections increases with the number of blood samples obtained for culture. The newer continuous monitoring automated blood culture systems with enhanced culture media show increased yield and sensitivity. Hence, we aimed at studying the role of single and multiple blood specimens from different sites at the same time in the outcome of automated blood culture system.Materials and Methods and Results:A total of 1054 blood culture sets were analyzed over 1 year, the sensitivity of one, two, and three samples in a set was found to be 85.67%, 96.59%, and 100%, respectively, which showed a statistically significant difference (P < 0.0001). Similar findings were seen in few more studies, however, among individual organisms in contrast to other studies, the isolation rates of Gram-positive bacteria were less than that of Gram-negative Bacilli with one (or first) sample in a blood culture set. In our study, despite using BacT/ALERT three-dimensional continuous culture monitoring system with FAN plus culture bottles, 15% of positive cultures would have been missed if only a single sample was collected in a blood culture set.Conclusion:The variables like the volume of blood and number of samples collected from different sites still play a major role in the outcome of these automated blood culture systems.

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“…Timely diagnosis and appropriate antimicrobial therapy have a major role in predicting the outcome of these infections. [ 1 ]…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparative evaluation of the role of single and multiple blood specimens in the outcome of blood cultures using BacT/ALERT 3D (automated) blood culture system in a tertiary care hospital

Elantamilan

Lyngdoh

Khyriem

et al. 2016

Indian J Crit Care Med

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“…Clinical presentation ranges from benign transient bacteremia with J Lab Physicians:2020;12:56-67 little or no symptoms to fulminant septic shock with high mortality. 1 Bacteremia or fungemia denotes the presence of viable bacteria or fungi in the blood with or without clinical symptoms. Systemic inflammatory response syndrome (SIRS) is defined by the presence of two or more acute findings (tachycardia, leukocytosis, or leukocytopenia, fever or hypothermia, tachypnea).…”

Section: Introductionmentioning

confidence: 99%

“…With an attributable mortality rate of 15%, it is an eminent cause of death worldwide. 1 Presence of microbes in blood whether continuously, intermittently, or transiently is a grave risk to every organ of the body. Early diagnosis plays a crucial role in managing BSI and hence prompt detection of such infections is a critical function of clinical microbiology laboratories.…”

Section: Introductionmentioning

confidence: 99%

Ecology of Bloodstream Infections and Temporal Trends of Their Antibiograms with Respect to Source and Duration of Incubation: A 5-Year Retrospective Observational Analysis

et al. 2020

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Purpose Blood is one of the most important connective tissues of human body. Bloodstream infection can range from inapparent bacteremia till fulminant septic shock with high mortality. Presence of microbes in blood whether continuously, intermittently, or transiently is a grave risk to every organ of body. Culture of blood is a vital tool to diagnose such infections. Drug susceptibility patterns help in rationalizing therapy. Objective The aim of the study is to perform bacteriological analysis and assess drug sensitivity patterns of blood culture isolates and compare in light of other associated variables. Design Retrospective observational study was conducted from January 2009 to December 2013 at a tertiary care hospital at Shillong, India. Blood samples were collected with aseptic guidelines and cultured for 7 days. Growths were identified by standard biochemical tests and subjected to sensitivity testing according to Modified Kirby Bauer disk diffusion method. Data for source of blood collection and duration of incubation were noted and compared. Results A total of 658 (11.2%) pathogens were isolated from 5,867 bacteremia-suspected patient blood specimens. Contamination was observed at the rate of 1.21%. Gram-negative organisms were the predominant pathogens recovered, Klebsiella pneumoniae being the most common. No significant difference was observed between the number of organisms isolated within or beyond 48 hours. Acinetobacter baumannii and K. pneumoniae have significantly higher chances (p < 0.05) of isolation from central line catheters compared with peripheral venipuncture. Conclusion Successful treatment of sepsis depends on early diagnosis and proper antimicrobial therapy. Local knowledge of bacteriological profile and antimicrobial sensitivity patterns helps rationalize empiric treatment strategies.

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“…Blood cultures provide essential information for the evaluation of a several diseases like endocarditis, pneumonia, pyrexia of unknown origin and particularly, in patients with suspected septicemia (Yagupsky et al, 1990). Bloodstream Infections are a major cause of morbidity and mortality worldwide (Seifer et al, 2005). The blood culture is a critical tool for the health care professional to detect the pathogenic growth of living organisms in the bloodstream.…”

Section: Introductionmentioning

confidence: 99%

Frequency of Bacterial Pathogens and Antibacterial Susceptibility Pattern of Isolates from Blood Culture – A Retrospective Study from a Tertiary Care Hospital

Kavitha¹

2017

Int.J.Curr.Microbiol.App.Sci

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Bloodstream Infection and Endocarditis

Cited by 12 publications

References 560 publications

Comparative evaluation of the role of single and multiple blood specimens in the outcome of blood cultures using BacT/ALERT 3D (automated) blood culture system in a tertiary care hospital

Comparative evaluation of the role of single and multiple blood specimens in the outcome of blood cultures using BacT/ALERT 3D (automated) blood culture system in a tertiary care hospital

Ecology of Bloodstream Infections and Temporal Trends of Their Antibiograms with Respect to Source and Duration of Incubation: A 5-Year Retrospective Observational Analysis

Frequency of Bacterial Pathogens and Antibacterial Susceptibility Pattern of Isolates from Blood Culture – A Retrospective Study from a Tertiary Care Hospital

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