2019
DOI: 10.1370/afm.2445
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Blue-Light Therapy for Acne Vulgaris: A Systematic Review and Meta-Analysis

Abstract: PURPOSE Antibiotic use in acne treatment raises concerns about increased resistance, necessitating alternatives. We assessed the effectiveness of blue-light therapy for acne. METHODS We analyzed randomized controlled trials comparing blue light with nonlight interventions. Studies included people of any age, sex, and acne severity, in any setting, and reported on investigator-assessed change in acne severity, patients' assessment of improvement, change in inflammatory or noninflammatory lesions, and adverse ev… Show more

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Cited by 38 publications
(35 citation statements)
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“…UVR is also a major cause of aging in the skin (Amaro-Ortiz et al 2014 ; Chung et al 2018 ), but it is effective in promoting vitamin D synthesis and improving skin-related diseases, such as psoriasis (Morita 2018 ; Neale et al 2019 ). Blue light also causes oxidative stress, thereby slowing the recovery of skin barriers, and ultimately adversely affecting the skin (Vandersee et al 2015 ; Nakashima et al 2017 ), but also contributing positively to the removal of P. acne (Scott et al 2019 ). Therefore, it is valuable to utilize the beneficial effects of each wavelength of light under the appropriate conditions.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…UVR is also a major cause of aging in the skin (Amaro-Ortiz et al 2014 ; Chung et al 2018 ), but it is effective in promoting vitamin D synthesis and improving skin-related diseases, such as psoriasis (Morita 2018 ; Neale et al 2019 ). Blue light also causes oxidative stress, thereby slowing the recovery of skin barriers, and ultimately adversely affecting the skin (Vandersee et al 2015 ; Nakashima et al 2017 ), but also contributing positively to the removal of P. acne (Scott et al 2019 ). Therefore, it is valuable to utilize the beneficial effects of each wavelength of light under the appropriate conditions.…”
Section: Discussionmentioning
confidence: 99%
“…The positive effects of blue light have been reported in treating acne ( Acne vulgaris ) (Alexiades 2017 ; Scott et al 2019 ). Acne is a skin disease that primarily occurs during puberty and is observed in 85% of the adolescents.…”
Section: Introductionmentioning
confidence: 99%
“…TanIIA has four absorption bands in the range of 200–600 nm, and the maximum absorption of TanIIA in visible light spectrum is centered at blue light area. Blue light is widely used in clinical treatment of many dermatological diseases such as neonatal jaundice, acne and psoriasis (14–17). TanIIA is a photoactive molecule and unstable under the exposure of its absorption light, especially for the blue light (18–20).…”
Section: Introductionmentioning
confidence: 99%
“…23,24 Additionally, systemic corticosteroids pose an adjunctive therapy option in cases of severe inflammation, to speed up clearing of lesions for approaches using low starting dose of retinoids. 14,25,26 Finally, optical treatments including laser and light-based therapies (photodynamic therapy (PDT), light-emitting diode (LED), and intense pulsed light (IPL)) have gained increasing interest over the last years as acne treatments [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] in an attempt to overcome the limitations associated with the standard established therapies for moderateto-severe acne. 46 Among these newer therapeutic approaches, the use and effectiveness of FLE therapy have been described in the treatment of acne.…”
Section: Introductionmentioning
confidence: 99%