Blue Nevus With Satellite Lesions Mimicking Malignant Melanoma

Sardoy, A; Bidabehere, M.B.; Gubiani, María Laura; Pinardi, Beatriz

doi:10.1016/j.adengl.2017.04.013

Cited by 3 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Spindle cell lesions such as sclerotic/desmoplastic nevi are well known mimickers of MM, specifically DM [11][12][13][14]17 and capsular nevi are often are confused with DM because of their banal spindled cell morphology. 17 The IHC stains for sclerotic/desmoplastic nevi are uniformly positive for Melan-A and HMB-45, whereas usually negative in DM.…”

Section: Discussionmentioning

confidence: 99%

“…9,10 Capsular and sclerotic/desmoplastic nevi are well known mimickers of DM. [11][12][13][14] Moreover, it has been found from multiple studies that it can be extremely challenging to differentiate nevus from metastatic melanoma in an LN. 15,16 Herein, we report a similar case of metastatic melanoma with features of DM in SLN in a patient with primary superficial spreading melanoma (SSM) of leg with epithelioid features.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Metastatic Melanoma With Features of Desmoplastic Melanoma in a Patient With Primary Cutaneous Superficial Spreading Melanoma With Epithelioid Features

Modi

Moshiri

Klein

et al. 2021

The American Journal of Dermatopathology

View full text Add to dashboard Cite

The synchronous incidence of 2 different subtypes of melanoma is very rare. Desmoplastic melanoma (DM) can be a diagnostic challenge because of its frequent appearance as a dermal banal spindle cell proliferation. We present a case of a 30-year-old man who developed an irregular, purple, tender plaque measuring 2.5 cm on the right pretibial region. Wide excision of the right leg lesion showed superficial spreading melanoma with epithelioid cells and no spindle cell component. Sentinel lymph node (SLN) biopsy showed an atypical melanocytic proliferation involving one inguinal lymph node with subcapsular and intraparenchymal components. There were spindled tumor cells in lymph node capsule with hyperchromatic nuclei, which were nested within desmoplastic stroma, and were S100-and SOX10-positive and MART1-and HMB-45 negative; in addition to epithelioid tumor cells, which were S100-, SOX10-, and MART1-positive. Multiple discontinuous foci, subcapsular atypical melanocytes, and extracapsular extension helped in excluding capsular nevus. These findings were consistent with DM. Herein, we present an unusual case of primary cutaneous superficial spreading melanoma of the right leg with a predominantly epithelioid morphology that developed metastases to the SLN. The metastasis exhibited divergent differentiation, including both epithelioid morphology identical to the primary, but with additional features of DM that were nonoverlapping with the primary lesion.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Metastatic Melanoma With Features of Desmoplastic Melanoma in a Patient With Primary Cutaneous Superficial Spreading Melanoma With Epithelioid Features

Modi

Moshiri

Klein

et al. 2021

The American Journal of Dermatopathology

View full text Add to dashboard Cite

show abstract

“…The diagnosis of BN or CBN is usually not difficult. However, in a very few number of cases, including our case, a BN or CBN can accompanied by satellite lesions [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 93%

Recurrence of a Cellular Blue Nevus with Satellitosis—A Diagnostic Pitfall with Clinical Consequences

Kneitz

Rosé²,

Glutsch

et al. 2022

Dermatopathology

View full text Add to dashboard Cite

Blue nevus is a benign melanocytic lesion, typically asymptomatic and of unknown etiology. Several histologic and clinical variants have been distinguished, the most frequent being common blue nevus, cellular blue nevus, and combined blue nevus. Although melanocytic nevi with a satellite lesion are usually suggestive of locally advanced malignant melanoma, very few cases of blue nevi with satellite lesions have been reported. The diagnosis of common or cellular blue nevi is generally straightforward; however, the presence of structures such as irregular edges or satellitosis are highly suggestive for malignancy, and differential diagnoses such as locally advanced malignant melanoma and malignant blue nevus should be considered. Recurrent blue nevi can display atypical features not seen in the primary lesion, such as pleomorphism and mitotic activity. They usually tend to follow a benign course; however, in some cases, recurrence may indicate malignant transformation. We here report the unique case of a 64-year-old woman with a recurrent cellular blue nevus accompanied by satellite lesions. Such a biological behavior resulting in a clinical presentation as a melanoma-like lesion is a rarity in blue nevus and has not been described before.

show abstract

“…Blue nevus is an acquired or congenital form of melanocytic nevus with prominent blue/ steelgray pigmentation which results from the aggregation of melanocytes in the deep dermis [1]. Morphologically and dermoscopically, blue nevus may simulate malignant melanoma (MM) which can cause potential diagnostic pitfall [2]. Histopathological diagnosis is the substantial and definitive step to differentiate common blue nevus from blue nevi variants, MM or cutaneous metastasis of MM.…”

Section: Introductionmentioning

confidence: 99%

A Case of Blue Nevus Mimicking Malignant Melanoma Within a Keloid Scar

Bostan¹,

Yalıcı-Armağan²,

Gököz³

et al. 2021

Acta Medica

View full text Add to dashboard Cite

Blue nevus is a type of melanocytic nevus which clinically presents itself as blue/gray plaque or nodule. It most commonly develops upon distal extremities especially dorsal hands and feet, trunk and scalp. Histopathologically, heavy melanocyte aggregations in the deep dermis result in blue nevus formation. Different types of blue nevus include common blue nevus, cellular blue nevus, plaque-type blue nevus, combined blue nevus, desmoplastic blue nevus and subungal blue nevus. Although clinical findings may be sufficient to diagnose blue nevus, dermoscopy could be used as a helpful tool to aid in reaching the correct diagnosis. Dermoscopy usually shows diffuse blue-gray structureless area but since atypical clinical and dermoscopical features may be observed, histopathological diagnosis is the definitive step to differentiate blue nevus from its mimickers such as malignant melanoma. We want to present an interesting case of blue nevus mimicking malignant melanoma developing in a scar.

show abstract

Blue Nevus With Satellite Lesions Mimicking Malignant Melanoma

Cited by 3 publications

References 9 publications

Metastatic Melanoma With Features of Desmoplastic Melanoma in a Patient With Primary Cutaneous Superficial Spreading Melanoma With Epithelioid Features

Metastatic Melanoma With Features of Desmoplastic Melanoma in a Patient With Primary Cutaneous Superficial Spreading Melanoma With Epithelioid Features

Recurrence of a Cellular Blue Nevus with Satellitosis—A Diagnostic Pitfall with Clinical Consequences

A Case of Blue Nevus Mimicking Malignant Melanoma Within a Keloid Scar

Contact Info

Product

Resources

About