Blueberry extract prolongs lifespan of Drosophila melanogaster

Peng, Cheng; Zuo, Ya‐Gang; Kwan, Kin Ming; Liang, Yintong; Ying, Ka; Chan, Ho Yin Edwin; Huang, Yü; Yu, Huan; Chen, Zhenyu

doi:10.1016/j.exger.2011.12.001

Cited by 121 publications

(92 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antioxidant supplements, for example, appear to either have no effect on lifespan, or to increase morbidity and mortality in humans (McCormick 2010). In contrast to the results cited above, many antioxidants appear to extend the lifespan of worms or flies (e.g., Liao et al 2011;Peng et al 2012;Shen et al 2013). These results suggest that screening drugs and supplements in lower eucaryotes may be confounded by high false discovery rates.…”

Section: Discussionmentioning

confidence: 93%

Lifespan effects of simple and complex nutraceutical combinations fed isocalorically to mice

Spindler

Mote

Flegal

2013

AGE

View full text Add to dashboard Cite

Present data suggest that the consumption of individual dietary supplements does not enhance the health or longevity of healthy rodents or humans. It might be argued that more complex combinations of such agents might extend lifespan or health-span by more closely mimicking the complexity of micronutrients in fruits and vegetables, which appear to extend health-span and longevity. To test this hypothesis we treated long-lived, male, F1 mice with published and commercial combinations of dietary supplements and natural product extracts, and determined their effects on lifespan and health-span. Nutraceutical, vitamin or mineral combinations reported to extend the lifespan or health-span of healthy or enfeebled rodents were tested, as were combinations of botanicals and nutraceuticals implicated in enhanced longevity by a longitudinal study of human aging. A cross-section of commercial nutraceutical combinations sold as potential health enhancers also were tested, including Bone Restore®, Juvenon®, Life Extension Mix®, Ortho Core®, Ortho Mind®, Super K w k2®, and Ultra K2®. A more complex mixture of vitamins, minerals, botanical extracts and other nutraceuticals was compounded and tested. No significant increase in murine lifespan was found for any supplement mixture. Our diverse supplement mixture significantly decreased lifespan. Thus, our results do not support the hypothesis that simple or complex combinations of nutraceuticals, including antioxidants, are effective in delaying the onset or progress of the major causes of death in mice. The results are consistent with epidemiological studies suggesting that dietary supplements are not beneficial and even may be harmful for otherwise healthy individuals.

show abstract

Section: Discussionmentioning

confidence: 93%

Lifespan effects of simple and complex nutraceutical combinations fed isocalorically to mice

Spindler

Mote

Flegal

2013

AGE

View full text Add to dashboard Cite

show abstract

“…increase stress resistance in many species. 8,[42][43][44] Echinacoside (ECH) is one such natural polyphenol that is known to possess various important of pharmacological activities including antioxidative, antiinflammatory, neuroprotective, hepatoprotective, and nitric oxide radical-scavenging properties. 3,4) However, to the best of our knowledge, there have been no published in vivo studies addressing its effects on promoting longevity.…”

Section: Discussionmentioning

confidence: 99%

The longevity effect of echinacoside inCaenorhabditis elegansmediated throughdaf-16

Wang

Zhang

Liu

et al. 2015

Bioscience, Biotechnology, and Biochemistry

View full text Add to dashboard Cite

Echinacoside (ECH), a natural polyphenolic compound, has been reported to possess important pharmacological activities. However, very little is known about whether or how ECH affects longevity in vivo. We have examined the effects of ECH on the life span and stress tolerance in Caenorhabditis elegans. Our studies demonstrate that the life span of wild-type worms could be extended in the presence of ECH. Furthermore, ECH was found to increase tolerance of worms to heat shock and oxidative stress, while not exerting any influence on pharyngeal pumping rate and progeny production. Our mechanistic studies indicate that supplementation of ECH increases the transcript level of daf-16. ECH treatment also modulates the nuclear localization and transcriptional activities of daf-16, thus fine tunes the expression of daf-16 target genes to promote longevity and increases stress response in C. elegans. Overall, this work reveals the longevity effect of ECH and elucidates the underpinning mechanisms.

show abstract

“…We found ten studies on flavonoids and lifespan studies in D. melanogaster. Three of them used single compounds such as the flavanol epicatechin and the flavonol fisetin (58)(59)(60) , the other seven studies were on cocoa powder, green tea extract, Ludwigia octovalvis extract, apple polyphenols, black tea extract (BTE) and BE (61)(62)(63)(64)(65)(66)(67) (Table 2).…”

Section: Flavonoids and The Lifespan Of Drosophila Melanogastermentioning

confidence: 99%

A literature review of flavonoids and lifespan in model organisms

Pallauf¹,

Duckstein²,

Rimbach³

2016

Proc. Nutr. Soc.

View full text Add to dashboard Cite

Epidemiological data on consumption of flavonoid-containing food points to the notion that some of these secondary plant metabolites may favour healthy ageing. The aim of the present paper was to review the literature on lifespan extension by flavonoids in worms, flies and mice. In most studies, worms and flies experienced lifespan extension when supplemented with flavonoids either as extracts or single compounds. Studies with mutant worms and flies give hints as to which gene products may be regulated by flavonoids and consequently enhance longevity. We discuss the data considering putative mechanisms that may underlie flavonoid action such as energy-restriction-like effects, inhibition of insulin-like-growth-factor signalling, induction of antioxidant defence mechanisms, hormesis as well as antimicrobial properties. However, it remains uncertain whether human lifespan could be prolonged by increased flavonoid intake.

show abstract

Blueberry extract prolongs lifespan of Drosophila melanogaster

Cited by 121 publications

References 27 publications

Lifespan effects of simple and complex nutraceutical combinations fed isocalorically to mice

Lifespan effects of simple and complex nutraceutical combinations fed isocalorically to mice

The longevity effect of echinacoside inCaenorhabditis elegansmediated throughdaf-16

A literature review of flavonoids and lifespan in model organisms

Contact Info

Product

Resources

About