Blueberry muffin syndrome owing to congenital rubella: case report

Köklü, Esad; Kurtoğlu, Selim; Akçakuş, Mustafa; Köklü, Selmin; Güneş, Tamer; Köse, M Rıfat

doi:10.1179/146532806x107511

Cited by 8 publications

(5 citation statements)

References 5 publications

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“…There were 19 articles that met the inclusion criteria and contained sufficient data available for review. Of these, nine were based on catheterization data alone (Rowe,1963; Emmanouilides et al,1964; Venables,1965; Sperling and Verska,1966; Hastreiter et al,1967; Celermajer et al,1969; Lie et al,1970; Kher et al,1980; Gorenflo et al,2002), nine on echocardiographic data alone (Janner,1991; Robinson et al,1994; Bullens et al,2000; St John and Benjamin,2000; Agarwal et al,2001; Banerji et al,2005; Koklu et al,2006; Wui et al,2006; Plotinsky et al,2007), and one on both catheterization and echocardiographic data (Moore and Mullins,1986) (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

An update on cardiovascular malformations in congenital rubella syndrome

Oster

Riehle‐Colarusso

Correa

2009

Birth Defects Research

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BACKGROUND: Congenital rubella syndrome (CRS) has long been characterized by the triad of deafness, cataract, and cardiovascular malformations (CVMs). While initial reports identified patent ductus arteriosus (PDA) as the primary CVM in CRS, the exact nature of the CVMs found in CRS has not been well established. METHODS: We searched the English literature from 1941 through 2008 to identify studies that used cardiac catheterization or echocardiography to evaluate the CVMs in CRS. RESULTS: Of the 121 patients in the 10 studies with catheterization data, 78% had branch pulmonary artery stenosis, and 62% had a PDA. In 49% of cases, both branch pulmonary artery stenosis and PDA were present, whereas isolated branch pulmonary artery stenosis and isolated PDA were found in 29 and 13% of cases, respectively. Of the 12 patients in the 10 studies with echocardiographic data, PDA was more common than branch pulmonary artery stenosis, but this finding is greatly limited by the small numbers of patients and limitations of echocardiography. Although published studies of CVMs in CRS have in general reported PDA as the CVM phenotype most commonly associated with CRS, among CRS cases evaluated by catheterization, branch pulmonary artery stenosis was actually more common than PDA. Moreover, although the combination of branch pulmonary artery stenosis and PDA was more common than either branch pulmonary artery stenosis or PDA alone, isolated branch pulmonary artery stenosis was twice as common as isolated PDA. CONCLUSION: Among children with suspected CRS, clinical evaluations for the presence of CVMs should include examinations for both branch pulmonary artery stenosis and PDA.

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Section: Resultsmentioning

confidence: 99%

An update on cardiovascular malformations in congenital rubella syndrome

Oster

Riehle‐Colarusso

Correa

2009

Birth Defects Research

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“…However, if rubella is acquired during the first 10 weeks of pregnancy, the fetus is at high risk of congenital rubella syndrome (CRS) [1], with manifestations ranging from deafness, cardiac disease, and cognitive impairment to miscarriage and fetal death [2][3][4]. The incidence of CRS in Canada is rare, with an average of 0.69 cases per year between 1998 and 2010 [5].…”

Section: Introductionmentioning

confidence: 99%

Determining rubella immunity in pregnant Alberta women 2009–2012

Lai

Dover

Lee

et al. 2015

Vaccine

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“…In our patient, the rashes were present at birth and disappeared completely by 10th day. Koklu et al [10] reported late-onset blueberry muffin rash following congenital rubella.…”

Section: Discussionmentioning

confidence: 99%

Congenital rubella syndrome presenting at birth with blueberry muffin rash and communicating hydrocephalus

et al. 2015

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We report a preterm, small-for-gestational age, very low birth weight male neonate presenting at birth with generalized reddish blue papulonodular lesions (including palms and soles), anemia, thrombocytopenia, hepatosplenomegaly, interstitial pneumonitis, sensorineural deafness, atrial septal defect, and communicating hydrocephalus. A diagnosis of blueberry muffin rash in a child with congenital rubella syndrome and communicating hydrocephalus was made based on clinical and laboratory findings. The rash disappeared by 10th day of life.

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Blueberry muffin syndrome owing to congenital rubella: case report

Abstract: A case of congenital rubella is reported in a 22-day-old boy presenting with a 'blueberry muffin' rash. Late-onset blueberry muffin syndrome following congenital rubella is very rare.

Cited by 8 publications

References 5 publications

An update on cardiovascular malformations in congenital rubella syndrome

An update on cardiovascular malformations in congenital rubella syndrome

Determining rubella immunity in pregnant Alberta women 2009–2012

Congenital rubella syndrome presenting at birth with blueberry muffin rash and communicating hydrocephalus

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