Bluetongue and equine viral arteritis viruses as models of virus-induced fetal injury and abortion

Maclachlan, Nigel J; Conley, Alan J; Kennedy, P. C.

doi:10.1016/s0378-4320(00)00105-6

Cited by 78 publications

(64 citation statements)

References 32 publications

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“…We were however unable to obtain segment 2 RT-PCR amplicons from all blood and tissues sampled from the foetuses carried by goat 4, and it is therefore possible that other Immuno-tolerance and/or persistent/latent infections such as occur during the in utero exposure of cattle to bovine viral diarrhoea virus (BVDV) has not been demonstrated for BTV, despite prior reports of such occurrences (Luedke et al, 1977). The latter result therefore probably reflects the immaturity of the foetal immune system at the time of infection, as production of antibodies in ruminants only starts around mid gestation (Osburn, 1994;Maclachlan et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…Notwithstanding the absence of malformation in the present study, the potential teratogenicity of BTV infection in goats cannot be excluded. Documented transplacental infection and associated defects vary widely in sheep and cattle and is therefore unpredictable (Osburn, 1994;Maclachlan et al, 2000). Furthermore, in not all cases where animals were born either viraemic and/or PCR positive during the European outbreak of BTV-8 were nervous system lesions observed (De Clercq et al, 2008;Menzies et al, 2008;SantmanBerends et al, 2010;Saegerman et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

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Transplacental infection in goats experimentally infected with a European strain of bluetongue virus serotype 8

Coetzee

Stokstad

Myrmel

et al. 2013

The Veterinary Journal

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The capability of the current European strain of bluetongue virus serotype 8 (BTV-8) to cross the ruminant placenta has been established in experimental and field studies in both sheep and cattle. Sero-prevalence rates in goats in north-western Europe were high during the recent outbreak of BTV-8, however the capability of the virus to infect goats through the transplacental route has not been established. In the present study, four Saanen goats pregnant at 62 days of gestation were inoculated with the European strain of BTV-8, in order to investigate the capability of the virus to cross the caprine placenta. Infection of adult goats resulted in mild clinical signs, however gross lesions observed post mortem were more severe.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Transplacental infection in goats experimentally infected with a European strain of bluetongue virus serotype 8

Coetzee

Stokstad

Myrmel

et al. 2013

The Veterinary Journal

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“…(Luedke et al 1964, Mahrt & Osburn 1986. Infecção fetal causada pelo VLA tem sido relatada nos Estados Unidos e na África do Sul e associados com o uso de vacinas vivas modificadas (Maclachlan et al 2000). No mínimo quatro sorotipos de VLA (VLA-10, VLA-11, VLA-13 e VLA-17) já foram descritos como hábeis a cruzar a placenta e causar infecção fetal (Maclachlan et al 1985).…”

Section: Discussão E Conclusõesunclassified

Alterações clínicas e patológicas em ovinos infectados naturalmente pelo vírus da língua azul no Rio Grande do Sul

et al. 2010

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Língua azul (LA) é uma doença causada pelo vírus da língua azul (VLA) e transmitida por vetores do gênero Culicoides. Estudos sorológicos têm demonstrado a ampla presença do vírus no Brasil; entretanto, informações clínicas da LA na América do Sul são limitadas. Esse trabalho descreve alterações clínico-patológicas em ovinos acometidos pela LA no Sul do Brasil. Em dois surtos, em propriedades distintas, 15 ovinos apresentaram como principais sinais clínicos hipertermia, apatia, aumento de volume da face e região submandibular, dificuldade de deglutição com regurgitação, secreção nasal mucopurulenta esverdeada, alterações respiratórias, além de acentuada perda de peso e erosões na mucosa oral. Os achados de necropsia em seis ovinos afetados incluíram edema subcutâneo na face e região ventral do tórax, secreção nasal esverdeada, esôfago dilatado preenchido por grande quantidade de conteúdo alimentar, pulmões não colabados com áreas consolidadas anteroventrais, bem como luz da traquéia e brônquios preenchida por espuma misturada com conteúdo alimentar. No coração e base da artéria pulmonar, havia focos de hemorragia. Histologicamente, as principais alterações observadas ocorriam no tecido muscular cardíaco e esquelético, especialmente no esôfago e consistiam de lesões bifásicas caracterizadas por degeneração/necrose hialina e flocular de miofibras associadas com micro-calcificação e infiltrado inflamatório mononuclear. Pneumonia aspirativa associada à presença de material vegetal e bactérias na luz de brônquios também foi observada. O diagnóstico de LA foi confirmado pela detecção do genoma viral por duplex RT-PCR em amostras de sangue de animais afetados, seguido da identificação do VLA, sorotipo 12 por sequenciamento.

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“…In Europe BTV-8 appeared to cause transplacental infection, which was normally associated until now to live BTV strains adapted in cell culture (MacLachlan et al, 2000;Vercauteren et al, 2008;Wouda et al, 2008). The understanding of the viral pathogenesis in cattle during BTV-8 infection is still rather poor.…”

Section: Introductionmentioning

confidence: 99%

Experimental reproduction of bluetongue virus serotype 8 clinical disease in calves

Pozzo

Clercq

Guyot

et al. 2009

Veterinary Microbiology

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Bluetongue and equine viral arteritis viruses as models of virus-induced fetal injury and abortion

Cited by 78 publications

References 32 publications

Transplacental infection in goats experimentally infected with a European strain of bluetongue virus serotype 8

Transplacental infection in goats experimentally infected with a European strain of bluetongue virus serotype 8

Alterações clínicas e patológicas em ovinos infectados naturalmente pelo vírus da língua azul no Rio Grande do Sul

Experimental reproduction of bluetongue virus serotype 8 clinical disease in calves

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