2012
DOI: 10.1016/j.vetmic.2012.01.022
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Bluetongue virus serotype 6 in Europe in 2008—Emergence and disappearance of an unexpected non-virulent BTV

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Cited by 38 publications
(28 citation statements)
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“…Clinical surveillance based on the Central Veterinary Institute (CVI) score (17) and measurements of rectal temperature were conducted daily from 4 days before the first vaccination (V1) until the end of the challenge experiment (day 63). A rectal temperature of an individual animal that was more than 1 degree (°C) higher than the average rectal temperature during the 3 days before challenge was considered to represent the presence of fever.…”
Section: Cells and Viruses Bsr Cells (Bhk-21 Subclone)mentioning
confidence: 99%
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“…Clinical surveillance based on the Central Veterinary Institute (CVI) score (17) and measurements of rectal temperature were conducted daily from 4 days before the first vaccination (V1) until the end of the challenge experiment (day 63). A rectal temperature of an individual animal that was more than 1 degree (°C) higher than the average rectal temperature during the 3 days before challenge was considered to represent the presence of fever.…”
Section: Cells and Viruses Bsr Cells (Bhk-21 Subclone)mentioning
confidence: 99%
“…Fever was defined as the average temperature plus 2 times the standard deviation. Clinical signs were daily recorded according to the clinical score by clinical surveillance based on the CVI score table for BTV-8 animal trials (17). Samples of EDTA blood and serum were frequently collected until the end of the experiment.…”
Section: Cells and Viruses Bsr Cells (Bhk-21 Subclone)mentioning
confidence: 99%
“…Abortions and stillbirths have also been reported as well as lower milk production after vaccination with MLVs. Officially, MLVs for other serotypes were never used in Europe but have been detected, and are likely introduced via unknown introduction routes (De Clercq et al, 2009;van Rijn et al, 2012). In several parts of the world, such as the USA, Turkey, Africa, and India, MLVs are still used to protect the ruminant population against BT (Bhanuprakash et al, 2009;McVey & MacLachlan, 2015).…”
Section: Modified-live Vaccinesmentioning
confidence: 99%
“…The titer of DISA vaccine virus is, however, slightly lower, which would increase the costs for production. DISA vaccines are based on the backbone of BTV6/net08, a well-known BTV strain related to MLV for serotype 6 (Maan et al, 2010;van Rijn et al, 2012). Further, it contains a deletion in Seg-10 abolishing NS3/ NS3a expression (Feenstra et al, 2014c).…”
Section: Disabled Infectious Single-animal (Disa) Vaccinementioning
confidence: 99%
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