BMAL1 regulates <i>Propionibacterium acnes</i>-induced skin inflammation via REV-ERBα in mice

Li, Feng; Lin, Luomin; He, Yongtao; Sun, Guanghui; Dong, Dong; Wu, Baojian

doi:10.7150/ijbs.71719

Cited by 10 publications

(12 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Inflammatory arthritis [ 79 , 80 ], neuroinflammation [ 81 , 82 ] and metabolic inflammation [ 83 ] have been linked to the biological clock. In addition, inflammation of the retina [ 84 ], skin [ 85 ] and lungs [ 86 , 87 , 88 ] has been linked to circadian rhythms.…”

Section: Discussionmentioning

confidence: 99%

“…Consequently, the immune response via IL-1β was suppressed and inflammation was alleviated. BMAL1 regulatory effects on inflammation have also been linked to REV-ERBα [ 85 ]. In Bmal1 knockout mice with skin inflammation, p65 and NLRP3 levels were increased compared to their wild-type counterpart [ 85 ].…”

Section: Discussionmentioning

confidence: 99%

“…BMAL1 regulatory effects on inflammation have also been linked to REV-ERBα [ 85 ]. In Bmal1 knockout mice with skin inflammation, p65 and NLRP3 levels were increased compared to their wild-type counterpart [ 85 ]. Rev-erbα −/− mice were more sensitive to skin inflammation associated with the direct effects of clock genes on NLRP3 [ 63 , 85 ].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Relationship between the Biological Clock and Inflammatory Bowel Disease

Giebfried,

Lorentz

2023

Clocks & Sleep

View full text Add to dashboard Cite

The biological clock is a molecular oscillator that generates a 24-hour rhythm in accordance with the earth’s rotation. Physiological functions and pathophysiological processes such as inflammatory bowel diseases (IBD) are closely linked to the molecular clock. This review summarizes 14 studies in humans and mice on the interactions between the biological clock and IBD. It provides evidence that IBD negatively affect core clock gene expression, metabolism and immune functions. On the other hand, disruption of the clock promotes inflammation. Overexpression of clock genes can lead to inhibition of inflammatory processes, while silencing of clock genes can lead to irreversible disease activity. In both human and mouse studies, IBD and circadian rhythms have been shown to influence each other. Further research is needed to understand the exact mechanisms and to develop potential rhythm-related therapies to improve IBD.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship between the Biological Clock and Inflammatory Bowel Disease

Giebfried,

Lorentz

2023

Clocks & Sleep

View full text Add to dashboard Cite

show abstract

“…The transcription factor BMAL1, an essential component of the molecular clock, regulates the upregulation of IL-6 in lipopolysaccharide-exposed microglia and plays a role in microglial inflammatory responses (45). The loss of BMAL1, or jetlag-sensitised mice, acts on the NF-kB/NLRP3 axis to promote inflammation, which exacerbates Propionibacterium acnes-induced skin inflammation (46). In addition, BMAL1 plays an important role in critical limb ischemia by activating IL-10, which transcriptionally suppresses inflammation and promotes angiogenesis via the transcriptional regulation of vascular endothelial growth factor expression (47).…”

Section: Discussionmentioning

confidence: 99%

BMAL1/FOXA2-induced rhythmic fluctuations in IL-6 contribute to nocturnal asthma attacks

Tang

Liu²,

Sun³

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

The circadian clock is closely associated with inflammatory reactions. Increased inflammatory cytokine levels have been detected in the airways of nocturnal asthma. However, the mechanisms that contribute to the nocturnal increase in inflammatory responses and the relationship with circadian clock remain unknown.MethodsInflammatory cytokine levels were measured in asthma patients with and without nocturnal symptoms. Allergic airway disease was induced in mice by ovalbumin (OVA), and different periods of light/dark cycles were used to induce circadian rhythm disorders. Serum shock was used to stimulate the rhythmic expression in human bronchial epidermal cells (16HBE). The expression and oscillation of circadian clock genes and inflammatory cytokines in 16HBE cells subjected to brain and muscle ARNT-like protein-1 (BMAL1) and Forkhead Box A2 (FOXA2) knockdown and treatment with a FOXA2 overexpression plasmid were assessed.ResultsSerum IL-6 was found to be significantly higher in asthmatic patients with nocturnal symptoms than those without nocturnal symptoms. The OVA-induced asthma model with a circadian rhythm disorder and 16HBE cells treated with serum shock showed an increase in IL-6 levels and a negative correlation with BMAL1 and FOXA2. The knockdown of BMAL1 resulted in a lower correlation between IL-6 and other rhythm clock genes. Furthermore, knockdown of the BMAL1 and FOXA2 in 16HBE cells reduced the expression and rhythmic fluctuations of IL-6.ConclusionsOur findings suggest that there are increased IL-6 levels in nocturnal asthma resulting from inhibition of the BMAL1/FOXA2 signalling pathway in airway epithelial cells.

show abstract

“…SR8278 (a synthetic compound) is identified as an antagonist of REV-ERBα and widely used to probe the function of REV-ERBα (Kojetin et al, 2011;Pardee et al, 2011). Notably, we recently found that REV-ERBα restrains Propionibacterium acnes-induced skin inflammation through inhibiting the NF-κB/NLRP3 axis to protect against acne vulgaris (Li et al, 2022). However, it remains elusive whether and how REV-ERBα regulates skin aging.…”

Section: Introductionmentioning

confidence: 99%

Scutellaria baicalensis Georgi regulates REV-ERBα/BMAL1 to protect against skin aging in mice

Sun

Dang²,

Zeng³

et al. 2022

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

Scutellaria baicalensis Georgi (SBG) is a traditional Chinese medicine widely used to treat disorders such as hypertension, dysentery and hemorrhaging. Here, we aimed to assess the pharmacological effects of SBG on skin aging and to investigate the underlying mechanisms. Mice with skin aging were established by treatment with D-galactose and ultraviolet-B. SBG (topical application) showed a protective effect on skin aging in mice, as evidenced by less formation of skin wrinkles, higher levels of SOD (superoxide dismutase) and HYP (hydroxyproline) as well as a lower level of MDA (malondialdehyde). In the meantime, skin MMP-1 and p53 expression were lower, epidermis was thinner and collagen amount was higher in SBG-treated mice. Anti-skin aging effects of SBG were also confirmed in NIH3T3 and HaCaT cells, as well as in mouse primary dermal fibroblasts and human primary epidermal keratinocytes. Furthermore, we found that loss of Rev-erbα (a known repressor of Bmal1) up-regulated skin BMAL1 (a clock component and a known anti-aging factor) and ameliorated skin aging in mice. Moreover, SBG dose-dependently increased the expression of BMAL1 in the skin of aged mice and in senescent NIT3H3 cells. In addition, based on a combination of Gal4 chimeric, luciferase reporter and expression assays, SBG was identified as an antagonist of REV-ERBα and thus an inducer of BMAL1 expression. In conclusion, SBG antagonizes REV-ERBα to up-regulate BMAL1 and to protect against skin aging in mice.

show abstract

BMAL1 regulates Propionibacterium acnes-induced skin inflammation via REV-ERBα in mice

Cited by 10 publications

References 42 publications

Relationship between the Biological Clock and Inflammatory Bowel Disease

Relationship between the Biological Clock and Inflammatory Bowel Disease

BMAL1/FOXA2-induced rhythmic fluctuations in IL-6 contribute to nocturnal asthma attacks

Scutellaria baicalensis Georgi regulates REV-ERBα/BMAL1 to protect against skin aging in mice

Contact Info

Product

Resources

About