BMI and body fat mass is inversely associated with vitamin D levels in older individuals

Araghi, Sadaf Oliai; Dijk, Suzanne C. van; Ham, Annelies C.; Brouwer‐Brolsma, Elske M.; Enneman, Anke W.; Sohl, E.; Swart, Karin M. A.; Zwaluw, Nikita L. van der; Wijngaarden, J.P. van; Dhonukshe-Rutten, R.A.M.; Schoor, Natasja M. van; Zillikens, M. Carola; Lips, Paul; Groot, L. de; Uitterlinden, André G.; Velde, Nathalie van der

doi:10.1007/s12603-015-0507-y

Cited by 14 publications

(18 citation statements)

References 35 publications

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“…Negative correlations of 25(OH)D and BMI support the evidence reported elsewhere and showing deficits of vitamin D in obesity. 43 Our results obtained from the adult population with a BMI of 30 kg/m 2 or higher compared with those from the normal-weight population distinctly confirm an increased risk of deficiency, and therefore are compelling in the context of public health. Special recommendations for an increased vitamin D supplementation should be addressed to the groups of overweight or obese men and women.…”

Section: 192324supporting

confidence: 50%

“…This finding seems contradictory to a commonly held notion that older age is a risk factor for the deficiency resulting from ineffective skin synthesis and age--related negative metabolic influence of fat tissue. 43 Possible explanation of our results may include higher awareness of the older population regarding the needs of vitamin D supplementation, prevention of osteoporosis, and perhaps more leisure time spent outdoor, compared with younger generations. In fact, we did not have data on lifestyle and habits of our participants, which should be regarded a limitation of this study.…”

Section: 192324mentioning

confidence: 83%

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Vitamin D status in Poland

Płudowski¹,

Ducki²,

Konstantynowicz³

et al. 2016

Polish Archives of Internal Medicine

102

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functions of vitamin D seem to be higher (30-50 ng/ml; 75-125 nmol/l), 25 but still are considered uncertain. Some authors, however, argue that even for proper bone mineralization, levels higher than 30 ng/ml (75 nmol/l) are necessary. 26 Indisputably, low 25(OH)D levels (below 20 ng/ml) are common and were reported worldwide, 1-7 and this is a drawback because epidemiological data underlined an association between vitamin D deficit and a higher risk for chronic conditions and multimorbidity, including musculoskeletal disorders, cancer, autoimmune diseases, cardiovascular disease, diabetes, and infectious diseases. 1,3,[27][28][29][30] One of the countries with limited data on vitamin D status is Poland (49-54°N; Central Europe). Results of studies carried out in our country indicated that the problem of vitamin D deficiency considerably affects the Polish population. In a study of 448 adult residents of urban areas INTRODUCTION Vitamin D is an important prohormone that can be synthesized by the skin exposed to sunlight (UVB) or ingested with food. However, low outdoor activity, sun protection, and low vitamin D content of staple foods reduce the significance of sun and diet as natural sources for efficacy of vitamin D metabolism and related health effects. In consequence, evidence from various populations highlighted vitamin D deficiency as a public health problem with high prevalence.1-17 The prevalence of vitamin D deficiency depends on diagnostic thresholds defining vitamin D status that is determined by total serum 25(OH)D levels, 18 and the recommended levels of 25(OH)D are still an issue of debate.19-22 Currently, it is accepted that maintaining serum 25(OH) D at a level of 20 ng/ml (50 nmol/l) or above is beneficial at least for bone health and calcium homeostasis.23,24 Levels required for noncalcemic PATIENTS AND METHODSThis cross-sectional study included a total of 5775 adult volunteers (4464 women; 1311 men; mean age, 54.0 ±15.9 years; range, 15.6-89.8 years), who were enrolled and examined through late winter and spring 2014. Serum concentrations of 25(OH)D were determined using the Liaison XL system (DiaSorin; CLIA method). Demographic and anthropometric data were also analyzed. RESULTSThe mean 25(OH)D concentration in the studied population was 18.0 ±9.6 ng/ml; 65.8% of the patients had 25(OH)D levels of less than 20 ng/ml; 24.1% had suboptimal levels of 20 to 30 ng/ml; and only 9.1% demonstrated the optimal levels of 30 to 50 ng/ml. In 89.9% of the studied population, 25(OH)D levels of less than 30 ng/ml were found. Obesity, defined as body mass index (BMI) over 30 kg/m 2 , was associated with lower 25(OH)D levels compared with normal weight (15.8 ±8.5 vs 18.5 ±9.7 ng/ml; P <0.0001). Lower 25(OH)D levels were observed in men, younger individuals, and individuals with excess body weight and higher BMI. CONCLUSIONSThe results of our study, which involved the most representative sample size of Polish adults, support the previously reported data on vitamin D status. The levels of 25(OH)D determined f...

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Section: 192324supporting

confidence: 50%

Section: 192324mentioning

confidence: 83%

Vitamin D status in Poland

Płudowski¹,

Ducki²,

Konstantynowicz³

et al. 2016

Polish Archives of Internal Medicine

102

View full text Add to dashboard Cite

show abstract

“…As a result, any extra fat mass gained can become a storage site for the fat-soluble vitamin D in the body [22], which leads to less vitamin D being released into the blood circulation [19]. There are possibilities that the ongoing changes in body composition among older adults and different obesity indicators make the relationship between different anthropometric indices, such as body mass index (BMI), waist circumference and body fat percentage with vitamin D status to be inconsistent [23][24][25][26]. Therefore, it is essential to consider various anthropometric indices that can be utilized to estimate vitamin D status among older adults.…”

Section: Introductionmentioning

confidence: 99%

High body fat percentage and low consumption of dairy products were associated with vitamin D inadequacy among older women in Malaysia

et al. 2020

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Background Serum vitamin D insufficiency is a public health issue, especially among older women. Sun exposure is fundamental in the production of vitamin D, but older women have less optimal sun exposure. Therefore, factors such as body composition and diet become more essential in sustaining sufficient serum levels of vitamin D. The objective of the current study is to determine factors contributing towards serum vitamin D insufficiency among 214 older women. Methods The respondents had their body weight, height, waist circumference and body fat percentage measured, as well as interviewed for their socio-demographic characteristics, sun exposure and dietary intake. Fasting blood samples were obtained from the respondents to measure their serum 25-hydroxyvitamin D [25(OH)D] concentration. Results There were 82.7% (95% CI: 77.6%, 87.8%) of the respondents that had serum vitamin D insufficiency (< 50 nmol/L) with an average of 37.4 ± 14.3nmol/L. In stepwise multiple linear regression, high percentage of body fat (ß =-0.211, p <0.01) and low consumption of milk and dairy products (ß = 0.135, p <0.05) were the main contributors towards insufficient serum vitamin D levels, but not socio-demographic characteristics, other anthropometric indices, sun exposure and diet quality.

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“…this finding, including sex-specific differences in education level (P < 0.001), age-related hormone reduction, genetics, comorbidities such as depression (P < 0.001) and brain glucose metabolism [31]. Another explanation may rely on the greater prevalence of vitamin D insufficiency in women compared to men in the present study (P < 0.001), likely due to a higher BMI in women (27 vs. 24 kg m À2 , P < 0.001) [32].…”

Section: As-measured Vitamin Dmentioning

confidence: 70%