BMI, physical activity, and breast cancer subtype in white, black, and Sea Island breast cancer survivors

Ford, Marvella E.; Bauza, Colleen; Findlay, Victoria J.; Turner, David P.; Abraham, Latecia M.; Moore, Leslie A.; Magwood, Gayenell; Alberg, Anthony J.; Gaymon, Kadeidre; Knight, Kenneth R.; Hilton, Ebony J.; Malek, Angela M.; Kramer, Rita; Peterson, Lindsay L.; Gregoski, Mathew J.; Bolick, Susan; Hurley, Deborah; Mosley, Catishia; Hazelton, Tonya R.; Burshell, Dana; Nogueira, Lourdes M.; Mack, Franshawn; Brown, Elizabeth A.; Salley, Judith D.; Whitfield, Keith E.; Esnaola, Nestor F.; Cunningham, Joan E.

doi:10.1016/bs.acr.2020.01.005

Cited by 7 publications

(8 citation statements)

References 11 publications

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“…Previous studies have shown that overweight or obesity is associated with an increased risk of luminal tumors 31 . In this study, we observed that women with luminal A breast cancer who were overweight/obese had a 50% higher risk of being diagnosed at a non‐early stage.…”

Section: Discussionsupporting

confidence: 46%

“…Previous studies have shown that overweight or obesity is associated with an increased risk of luminal tumors. 31 In this study, we observed that women with luminal A breast cancer who were overweight/obese had a 50% higher risk of being diagnosed at a non‐early stage. Consistent with our results, studies found that women with BMI > 25.0 kg/m 2 were 40%–70% more likely to be at a later stage than those with BMI < 25 kg/m 2 .…”

Section: Discussionmentioning

confidence: 65%

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Disparities in stage at diagnosis among breast cancer molecular subtypes in China

Zeng

et al. 2023

Cancer Medicine

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Background Disease stage at diagnosis and molecular subtypes are the main determinants of breast cancer treatment strategies and prognosis. We aimed at examining the disparities and factors associated with the stage at diagnosis among the molecular subtypes in breast cancer patients in China. Methods We identified patients with first primary breast cancer diagnosed between January 1, 2016, and December 31, 2017, from 23 hospitals in 12 provinces in China. We analyzed the proportion of non‐early‐stage (stages II–IV) breast cancer cases based on the family history of breast cancer, body mass index (BMI), insurance status, and molecular subtypes. Multivariable analyses were used to estimate the factors associated with non‐early‐stage diagnosis among the molecular subtypes. We further compared these estimates with that in the United States using the Surveillance, Epidemiology, and End Results database. Results A total of 9398 Chinese were identified with first primary invasive breast cancer. Of the 8767 patients with known stages, the human epidermal growth factor receptor 2 (HER2)‐enriched subtype had the highest proportion of stages II–IV (76.6%) patients, followed by triple‐negative breast cancer (73.2%), luminal B (69.9%), and luminal A (62.3%). The percentage of non‐early‐stage patients was higher in women with overweight or obesity than in those with a body mass index (BMI) <25 kg/m2 (adjusted odds ratio [OR] 1.3, 95% confidence interval (CI) 1.1–1.4). Patients with a family history of breast cancer had a higher likelihood of early‐stage (adjusted OR 0.7, 0.5–0.8) breast cancer. Patients with rural insurance had a substantially higher risk of non‐early‐stage disease than those with urban insurance (adjusted OR 1.8, 1.4–2.2). Regarding the subtype, being overweight/obese only increased the risk of non‐early‐stage in luminal A breast cancer. Compared with the United States, China had a higher proportion of non‐early‐stage breast cancer for all subtypes, with the largest gap in luminal A (adjusted OR 2.2, 95% CI 2.0–2.4). Conclusion The wide disparities in stage at breast cancer diagnosis imply that China urgently needs to improve early breast cancer diagnosis and health equity.

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Section: Discussionsupporting

confidence: 46%

Section: Discussionmentioning

confidence: 65%

Disparities in stage at diagnosis among breast cancer molecular subtypes in China

Zeng

et al. 2023

Cancer Medicine

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“…The effect of increased body mass index (BMI) on cancer risk has been studied thoroughly; however, this factor has rarely been examined in relation to cancer mortality [11][12][13][14]. The potential harmful effect of high BMI on cancer risk and mortality appears to be due to a genotoxic stress produced by a state of chronic inflammation in adipose tissue, contributing to carcinogenesis and cancer progression [15].…”

Section: Introductionmentioning

confidence: 99%

The Role of Diet, Alcohol, BMI, and Physical Activity in Cancer Mortality: Summary Findings of the EPIC Study

et al. 2021

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Evidence on the impact of diet, alcohol, body-mass index (BMI), and physical activity on mortality due to cancer and other cancer-related outcomes is still scarce. Herein, we reviewed the contribution of the European Prospective Investigation into Cancer and Nutrition (EPIC) study to the current state of the art on the role of these factors in cancer mortality. We identified 45 studies using a rapid systematic review methodology. Dietary factors associated with reduced cancer mortality included raw vegetable intake; dietary fiber intake; the Mediterranean diet; other dietary scores; other diet patterns including low meat eaters, vegetarians/vegans, or fish eaters; dietary intake (or biomarkers) of some vitamins (e.g., vitamin D, vitamin K2, or Vitamin C); and intake of lignans. Physical activity and following healthy lifestyle recommendations also reduced cancer mortality risk. In contrast, dietary factors associated with higher cancer mortality risk included poor diet quality, consumption of alcohol and soft drinks including juice, and, to a lesser extent, intake of some fatty acids. Excess weight and obesity also increased the risk of cancer mortality. The EPIC study holds valuable information on diet and lifestyle factors and offers a unique opportunity to identify key diet-related factors for cancer mortality prevention.

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“…In premenopausal women, a negative correlation between obesity and the risk of oestrogen-positive cancer was most commonly found, while obesity was associated with an increased risk of oestrogen-negative and triple-negative breast cancer. However, regardless of hormonal status, obesity is a poor prognostic factor for overall survival time, and dietary change and increased physical activity may contribute to prolonged survival [24][25][26][27]. In our study, adequate to the elevated BMI, an elevated adipose tissue content was observed, which concerned mainly postmenopausal patients.…”

Section: Discussionmentioning

confidence: 51%

The Impact of Dietary Counselling on Achieving or Maintaining Normal Nutritional Status in Patients with Early and Locally Advanced Breast Cancer Undergoing Perioperative Chemotherapy

et al. 2022

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Background: Obesity is an independent prognostic factor and is associated with poorer response to oncological treatment of breast cancer. Obesity is associated with shorter overall survival and shorter time to recurrence. Material and methods: The study included 104 breast cancer patients qualified for neoadjuvant chemotherapy. The control group consisted of 40 patients who refused to participate in the study. Consultation before chemotherapy included: author’s diet questionnaire, body composition analysis, nutrition education. After chemotherapy, the effects of the first dietary advice were evaluated. Results: More than half of all women had a BMI above normal before treatment. Analysis of the effects of nutrition education showed a significant improvement in body composition. After education, a slight increase in body weight and a significant decrease in fat mass and fat percentage were observed. In women who did not participate in education, a statistically significantly greater increase in body weight after chemotherapy was noted. Nutrition education of the study group did not prevent adverse changes in lipid profile resulting from chemotherapy. Conclusions: Dietary counselling prior to neoadjuvant chemotherapy may limit weight gain and may also influence fat mass reduction. Implementation of dietary recommendations does not guarantee maintenance of normal lipid parameters during chemotherapy.

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BMI, physical activity, and breast cancer subtype in white, black, and Sea Island breast cancer survivors

Cited by 7 publications

References 11 publications

Disparities in stage at diagnosis among breast cancer molecular subtypes in China

Disparities in stage at diagnosis among breast cancer molecular subtypes in China

The Role of Diet, Alcohol, BMI, and Physical Activity in Cancer Mortality: Summary Findings of the EPIC Study

The Impact of Dietary Counselling on Achieving or Maintaining Normal Nutritional Status in Patients with Early and Locally Advanced Breast Cancer Undergoing Perioperative Chemotherapy

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