BMI, spKt/V, and SBP but Not DBP Are Related to LVH in Chinese Maintenance Hemodialysis Patients

Cao, Xuesen; Zou, Jianzhou; Teng, Jie; Zhong, Yun‐Shi; Ji, Jun; Chen, Zhangwei; Z, Liu; Shen, Bo; Ding, Xiaoqiang

doi:10.3109/0886022x.2011.559299

Cited by 10 publications

(7 citation statements)

References 26 publications

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“…As depicted in Table 1 , SBP was significantly greater in hypertensive patients with baseline ECG LVH, which was consistent with a previously reported study by Cao et al [ 20 ] Therefore, ECG LVH could be considered an early indicator of poor BP management. After adjusting for multiplicity, the current study indicated that hypertensive patients with baseline ECG LVH exhibited a higher rate of unsatisfactory BP control (Table 2 ) and significantly smaller changes in SBP and DBP (Table 2 ).…”

Section: Discussionsupporting

confidence: 91%

Value of electrocardiographic left ventricular hypertrophy as a predictor of poor blood pressure control

et al. 2018

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Recent studies have shown that hypertension is poorly controlled in many populations worldwide. Electrocardiographic left ventricular hypertrophy is a common manifestation of preclinical cardiovascular disease that strongly predicts cardiovascular disease morbidity and mortality. However, little information is available regarding the role of left ventricular hypertrophy in blood pressure (BP) control. We aimed to assess the relationship between electrocardiographic left ventricular hypertrophy and BP control in the China Stroke Primary Prevention Trial. The study population included 17,312 hypertensive patients who were selected from a group of 20,702 adults who had participated in the China Stroke Primary Prevention Trial and had undergone electrocardiography at baseline visit. Multivariate analysis identified left ventricular hypertrophy as a predictor of unsatisfactory BP control. The results revealed that 8.1% of hypertensive adults exhibit left ventricular hypertrophy and that the disease is more prevalent in males (12.8%) than in females. Multivariate regression analysis showed that the electrocardiographic left ventricular hypertrophy group had a significantly higher rate of unsatisfactory BP control [odds ratio (OR) 1.42, 95% confidence interval (95% CI) 1.26–1.61, P < .001) than the nonleft ventricular hypertrophy group.Notable differences in BP control were also observed among males (OR 1.37, 95% CI 1.17–1.60, P < .001) and females (OR 1.45, 95% CI 1.18–1.77, P < .001) and especially among patients with comorbid diabetes (OR 2.32, 95% CI 1.31–4.12, P = .004). In conclusion, the results of this study indicate that electrocardiographic left ventricular hypertrophy appears to be an independent predictive factor for poor BP control, especially in females and patients with comorbid diabetes.

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Section: Discussionsupporting

confidence: 91%

Value of electrocardiographic left ventricular hypertrophy as a predictor of poor blood pressure control

et al. 2018

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“…Severity of anaemia could very well predict the left ventricular dimension and thickness in both male as well as female patients, and therefore risk of CVDs. 10,11…”

Section: Male Femlae 63mentioning

confidence: 99%

A study on correlation of anemia with left ventricular hypertrophy in chronic kidney disease patients: a cross sectional study from Southern Rajasthan

Meena

Meghwal²,

Meena³

et al. 2022

Int J Adv Med

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Background: Chronic kidney disease is becoming epidemic of twenty-first century. With increasing burden of diabetes and hypertension, chronic kidney disease is becoming rampant in our country. Adverse outcome of CKD includes kidney failure, complications due to decreased kidney function and cardiovascular disease etc. Increasing morbidity and mortality of coronary artery disease in CKD patients make it necessary to develop further researches in these population. Aim and objectives of current study were to demonstrate the correlation of anemia with left ventricular hypertrophy in a cohort of CKD patients in a tertiary care centre.Methods: This study was done over one year on 100 patients of CKD (stage III to V), aged 15-80 years, who had elevated serum creatinine and reduced glomerular filtration rate, haemoglobin <11 gm/dl with ultrasonographic evidence of renal parenchymal disease grade >2. The patients were assessed based on clinical history and a number of laboratory parameters including blood urea, serum creatinine, calcium, inorganic phosphorus, serum electrolytes, iPTH level, Hb, Hct, glomerular filtration rate and left ventricular mass index.Results: There is a significant relationship between of anemia and left ventricular hypertrophy among chronic kidney disease patients. In our study, it was observed that left ventricle mass (left ventricular mass index) increases with increasing severity of anemia.Conclusions: Anemia is widely prevalent in our CKD patients. Severity of anemia is correlated to left ventricular hypertrophy in these patients. Hence correction of anemia early in these group of patients can halt or prevent cardiovascular morbidity and mortality.

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“…And low-dose dialysis may increase the accumulation of uremic toxins, resulting in suppression of red blood cell production and low response to erythropoiesis-stimulating agents 39 , 40 . In addition, spKt/V was negatively correlated with left ventricular mass index and an independent risk factor for Left ventricular hypertrophy 41 . This may be related to the control of volume overload, anemia and hypertension by increasing spKt/V.…”

Section: Discussionmentioning

confidence: 94%

The association between dose of hemodialysis and patients mortality in a prospective cohort study

Liu

Wang

Zhang

et al. 2022

Sci Rep

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Dialysis adequacy is a known risk factor for mortality in maintenance hemodialysis (MHD) patients. However, the optimal dialysis dose remains controversial. Therefore, we aimed to explore the relationship between dialysis dose and all-cause and cardiovascular disease (CVD) mortality among MHD. We examined the associations of dialysis dose with mortality in a cohort (n = 558) of MHD patients from 31 December 2015 to 31 December 2020. Dialysis adequacy was assessed using baseline Single-pool Kt/Vurea (spKt/V), which was categorized into three groups, and the lowest dose group was used as the reference category. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazards regression models. A total of 214 patients died (64.5% for CVD). Compared with the low-dose group, high-dose group could reduce the risk of all-cause mortality by 33% (HR = 0.67, 95% CI: 0.47–0.98). Of note, when stratification by age, high-dose group was associated with both lower all-cause (HR = 0.46, 95% CI: 0.26–0.81) and CVD mortality (HR = 0.42, 95% CI: 0.20–0.88) among patients with age below 65 years. When stratification by dialysis age, high-dose group was associated with decreased risk of CVD mortality (HR = 0.43, 95% CI: 0.20–0.91) among patients with dialysis age over 60 months. spKt/V is a simple index of hemodialysis dose used in clinical practice and a useful modifiable factor in predicting the risk of death, especially in MHD patients under 65 years old or dialysis age more than 60 months.

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BMI, spKt/V, and SBP but Not DBP Are Related to LVH in Chinese Maintenance Hemodialysis Patients

Cited by 10 publications

References 26 publications

Value of electrocardiographic left ventricular hypertrophy as a predictor of poor blood pressure control

Value of electrocardiographic left ventricular hypertrophy as a predictor of poor blood pressure control

A study on correlation of anemia with left ventricular hypertrophy in chronic kidney disease patients: a cross sectional study from Southern Rajasthan

The association between dose of hemodialysis and patients mortality in a prospective cohort study

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