BmNPV-miR-415 up-regulates the expression of TOR2 via Bmo-miR-5738

Cao, Xueliang; Huang, Yong; Xia, Dajing; Qiu, Zhiyong; Shen, Xingjia; Guo, Xijie; Zhao, Qiaoling

doi:10.1016/j.sjbs.2015.09.020

Cited by 14 publications

(10 citation statements)

References 20 publications

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“…Bmnpv-miR-3 is also a BmNPV-produced miRNA that could regulate the P6.9 protein and various viral proteins to escape the immune attack of host cells ( Singh et al, 2014 ). In addition to the direct regulation of multiple proteins, viral miRNAs can also indirectly regulate host miRNAs that can, in turn, regulate the protein expression ( Cao et al, 2017 ). BmNPV-miR-415 was also found that it could down-regulate the expression of Bmo-miR-5738 in BmN cells and indirectly affect the expression of TOR2 protein, which plays an important role in the growth and development of the host ( Cao et al, 2017 ).…”

Section: Regulation Of Bmnpv Infection In the Silkworm By Ncrnasmentioning

confidence: 99%

Multi-omics study and ncRNA regulation of anti-BmNPV in silkworms, Bombyx mori: an update

Fan,

Andoh,

Chen

2023

Front. Microbiol.

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Bombyx mori silkworm is an important economic insect which has a significant contribution to the improvement of the economy. Bombyx mori nucleopolyhedrovirus (BmNPV) is a vitally significant purulent virus that impedes the sustainable and stable development of the silkworm industry, resulting in substantial economic losses. In recent years, with the development of biotechnology, transcriptomics, proteomics, metabolomics, and the related techniques have been used to select BmNPV-resistant genes, proteins, and metabolites. The regulatory networks between viruses and hosts have been gradually clarified with the discovery of ncRNAs, such as miRNA, lncRNA, and circRNA in cells. Thus, this paper aims to highlight the results of current multi-omics and ncRNA studies on BmNPV resistance in the silkworm, providing some references for resistant strategies in the silkworm to BmNPV.

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Section: Regulation Of Bmnpv Infection In the Silkworm By Ncrnasmentioning

confidence: 99%

Multi-omics study and ncRNA regulation of anti-BmNPV in silkworms, Bombyx mori: an update

Fan,

Andoh,

Chen

2023

Front. Microbiol.

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“…TOR2, as a member of the phosphatidylinositol kinase-related kinase family, plays a critical role in metabolism, development, growth, and survival at the cellular and organism levels. Recently it has been revealed that TORE2 also upregulates the molting hormone 20E (Cao et al, 2017). Apoptosis in Sf9 cells due to the inhibition of miR-14 indicates that it is essential for constitutive cell survival.…”

Section: Viral Mirnas Exploit the Host Machinerymentioning

confidence: 99%

MicroRNA-Mediated Host-Pathogen Interactions Between Bombyx mori and Viruses

2021

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MicroRNAs (miRNAs), small non-coding RNAs of about 22 nucleotides, have been reported to regulate gene expression at the posttranscriptional level and are involved in several biological processes such as immunity, development, metabolism, and host-pathogen interactions. Apart from miRNAs encoded by the host, miRNAs produced by pathogens also regulate host genes to facilitate virus replication and evasion of the host defense responses. In recent years, accumulated studies suggest that viral infections alter the host miRNAs expression profile, and both cellular and viral miRNAs may play vital roles in host-pathogen interactions. Bombyx mori, one of the critical lepidopteran model species, is an economically important insect for silk production. The mechanism of interaction between B. mori and its pathogens and their regulation by miRNAs has been extensively studied. Therefore, in this review, we aim to highlight the recent information and understanding of the virus-encoding miRNAs and their functions in modulating viral and host (B. mori) genes. Additionally, the response of B. mori derived miRNAs to viral infection is also discussed. A detailed critical view about miRNAs’ regulatory roles in B. mori-virus interactions will help us understand molecular networks and develop a sustainable antiviral strategy.

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“…BmNPV-miR-1 downregulates the expression of the host GTP-binding nuclear protein Ran and results in a significant increase in viral load [11]. The expression of rapamycin isoform 2 ( tor2 ) is upregulated by BmNPV-miR-415 via Bmo-miR-5738, although tor2 is not a direct target gene of BmNPV-miR-415 [12]. SpltNPV-encoded miRNAs have been reported to downregulate nine host genes [13].…”

Section: Introductionmentioning

confidence: 99%

An Autographa californica nucleopolyhedrovirus-encoded microRNA, AcMNPV-miR-4, downregulates the expression of host gene alg-2

Zhao

Teng

Wang

2022

Journal of General Virology

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Autographa california multiple nucleopolyhedrovirus (AcMNPV)-encoded microRNAs (miRNAs) that regulate viral genes to achieve infection have been reported previously. Here, we report another AcMNPV encoded miRNA, AcMNPV-miR-4 (Ac-miR-4), which downregulated the host gene, apoptosis-linked gene (alg-2). This regulation was verified by dual-luciferase reporter assays. The effects of Ac-miR-4 on virus infection were assessed. The results showed that the production of infectious budded virions (BV) was decreased and the occlusion-derived virion (ODV) embedding into polyhedra was delayed when Sf9 cells were administered an overdose of Ac-miR-4. All these findings suggest that Ac-miR-4 prolongs cell lifespan and reduces virus virulence at a relatively early stage but increases ODV at a very late stage. This finding may be attributed to the downregulation effects of alg-2, which lead to weakened ALG-2 related functions, such as cell apoptosis, vesicle budding and protein transport.

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BmNPV-miR-415 up-regulates the expression of TOR2 via Bmo-miR-5738

Cited by 14 publications

References 20 publications

Multi-omics study and ncRNA regulation of anti-BmNPV in silkworms, Bombyx mori: an update

Multi-omics study and ncRNA regulation of anti-BmNPV in silkworms, Bombyx mori: an update

MicroRNA-Mediated Host-Pathogen Interactions Between Bombyx mori and Viruses

An Autographa californica nucleopolyhedrovirus-encoded microRNA, AcMNPV-miR-4, downregulates the expression of host gene alg-2

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