BMP-7-Induced Cell Cycle Arrest of Anaplastic Thyroid Carcinoma Cells via p21CIP1 and p27KIP1

Franzén, Åsa; Heldin, Nils‐Erik

doi:10.1006/bbrc.2001.5212

Cited by 72 publications

(56 citation statements)

References 47 publications

(41 reference statements)

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“…These include such key cancer pathways as Wnt/␤-catenin, PI3-K/PTEN, and MAPK/ERK (Aubin et al, 2004;He et al, 2004;Moustakas and Heldin, 2005;Pardali et al, 2005). Further, BMP signaling directly impinges on the cell cycle regulatory proteins p21 and Rb: BMP signaling regulates p21/Cip1/Waf1 expression in prostate cancer (Haudenschild et al, 2004) and thyroid carcinomas (Franzen and Heldin, 2001) and inhibits phosphorylation of Rb protein in breast cancer (Ghosh-Choudhury et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

A Human Bone Morphogenetic Protein Antagonist Is Down-Regulated in Renal Cancer

Blish

Wang²,

Willingham

et al. 2008

MBoC

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Section: Discussionmentioning

confidence: 99%

A Human Bone Morphogenetic Protein Antagonist Is Down-Regulated in Renal Cancer

Blish

Wang²,

Willingham

et al. 2008

MBoC

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“…in this system, BmP-2 and BmP-4 repress ER-induced downregulation of GnRH transcription by attenuating ERmAPK signaling. BMP-6 and BMP-7, in turn, increase oTSuKA dose-dependent suppression of DNA synthesis in neoplastic thyroid epithelial cells [88], the thyroid BMP system is likely to play a role in the suppression of thyroid tumorigenesis.…”

Section: Hypothalamic Bmp System and Gonadotropin-releasing Hormone (mentioning

confidence: 95%

Multiple Endocrine Regulation by Bone Morphogenetic Protein System

Otsuka

2010

Endocr J

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Abstract. Bone morphogenetic proteins (BMPs) were originally identified with regard to their actions to regulate ectopic formation of bone and cartilage and early embryonic development. Subsequently, our research program has investigated a BMP system that exists in the mammalian ovary and plays roles in regulating numerous granulosa cell functions. BMP ligands including BMP-2, -4, -6, -7 and -15 were found to inhibit gondotropin-dependent progesterone synthesis by granulosa cells, which led to the hypothesis that BMPs are a physiological luteinization inhibitor in growing ovarian follicles during the follicular phase of the ovarian cycle. The physiological importance of the BMP system for normal mammalian reproduction has been further recognized by the discovery of aberrant reproductive phenotypes of female sheep and humans having mutated genes encoding BMP-15. Physiological roles of BMPs in the pituitary, hypothalamus, adrenal and other tissues have also been discovered. Here we discuss recent advances in the understanding of autocrine/paracrine actions of BMPs in the systemic regulation of endocrine function.Key words: Bone morphogenetic protein, Folliculogenesis, Ovary, Reproduction, Steroidogenesis Bone morphogenetic proteins (BmPs) were originally isolated from bone tissues as proteins that induce bone and cartilage formation in ectopic extra-skeletal sites in vivo [1]. The amino acid sequences from the corresponding cDNAs revealed that BmP ligands are structurally classified into transforming growth factor (TGF)-β superfamily member. To date, more than 30 members of the TGF-β superfamily have been identified in various species [2,3]. There is no direct evidence that all molecules designated as BMPs can induce cartilage and/or bone formation, whereas it has been well established that BMPs regulate multiple biological processes including cell proliferation, apoptosis, differentiation and morphogenesis. in this review, the recent advances regarding critical BmP actions in the ovarian folliculogenesis, which has been mostly discovered by Shimasaki's laboratory [4,5], and in many of extra-gonadal endocrine tissues are introduced. i) molecular characteristics and receptor signaling of the Bmp systemLigands of the TGF-β superfamily are initially synthesized as large precursor proteins. The precursor proteins dimerize and then are cleaved by proteolytic processing to produce mature dimeric proteins. The BMPs are distinguished from other members by having seven, rather than nine, conserved cysteine residues in the mature region. Six of the seven common cysteines in the mature protein are linked within the subunit to form a rigid structure called a "cysteine knot." The re-

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“…Numerous studies have linked members of BMP family, BMP antagonists, and BMP receptors to cancer (12)(13)(14)(15)(16)(17)(18). However, available data on involvement of BMP family members in cancerogenesis is conflicting.…”

Section: Comparison Of Survivors and Deceased Patientsmentioning

confidence: 99%

“…It inhibits tubular cell dedifferentiation, mesenchyme transformation, apoptosis, and protects kidney from diabetic nephropathy, acute and chronic renal failure (8)(9)(10)(11). Dysregulation of BMP signaling has been suggested in carcinogenesis (12)(13)(14)(15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

Bone morphogenetic protein-7 expression is down-regulated in human clear cell renal carcinoma

Bašić‐Jukić¹,

Hudolin²,

Radic-Antolic³

et al. 2010

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2 ABSTRACTRecent studies demonstrated that the expression pattern of bone morphogenetic protein 7(BMP-7) is altered in different tumors. We determined expression of BMP-7 in human clear cell renal carcinoma (CCRC).Samples from cancer and corresponding healthy tissue were obtained from 20 patients who underwent nephrectomy for CCRC. Expression of BMP-7 mRNA was determined by RT-PCR and protein expression was analyzed by immunohistochemistry.RT-PCR showed strong downregulation of BMP-7 mRNA in cancer tissue.

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BMP-7-Induced Cell Cycle Arrest of Anaplastic Thyroid Carcinoma Cells via p21CIP1 and p27KIP1

Cited by 72 publications

References 47 publications

A Human Bone Morphogenetic Protein Antagonist Is Down-Regulated in Renal Cancer

A Human Bone Morphogenetic Protein Antagonist Is Down-Regulated in Renal Cancer

Multiple Endocrine Regulation by Bone Morphogenetic Protein System

Bone morphogenetic protein-7 expression is down-regulated in human clear cell renal carcinoma

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