BMP Implant Associated with Platelet-Rich Plasma in Orbit Fracture Repair

Ferraz, Fábio Henrique Da Silva; Schellini, Silvana Artioli; Schellini, Ricardo C.; Pellizon, Claudia H.; Hirai, Flávio E.; Padovani, Carlos Roberto

doi:10.1080/02713680801892020

Cited by 7 publications

(5 citation statements)

References 26 publications

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“…When implanted subcutaneously, BMP‐2 leads to ectopic bone formation by a series of events that recapitulate embryonic endochondral bone formation 26. Furthermore, BMPs have been used to promote healing of fractures, including those that exhibit nonunion, a pathologic condition associated with failure of fracture healing 27–30. BMPs also have been shown to have critical roles in the development of other organ systems 31, 32.…”

Section: Discussionmentioning

confidence: 99%

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Acute phosphate restriction leads to impaired fracture healing and resistance to BMP-2

Wigner

Luderer

Cox

et al. 2010

Journal of Bone and Mineral Research

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Hypophosphatemia leads to rickets and osteomalacia, the latter of which results in decreased biomechanical integrity of bones, accompanied by poor fracture healing. Impaired phosphate-dependent apoptosis of hypertrophic chondrocytes is the molecular basis for rickets. However, the underlying pathophysiology of impaired fracture healing has not been characterized previously. To address the role of phosphate in fracture repair, mice were placed on a phosphate-restricted diet 2 days prior to or 3 days after induction of a mid-diaphyseal femoral fracture to assess the effects of phosphate deficiency on the initial recruitment of mesenchymal stem cells and their subsequent differentiation. Histologic and micro-computed tomographic (µCT) analyses demonstrated that both phosphate restriction models dramatically impaired fracture healing primarily owing to a defect in differentiation along the chondrogenic lineage. Based on Sox9 and Sox5 mRNA levels, neither the initial recruitment of cells to the callus nor their lineage commitment was effected by hypophosphatemia. However, differentiation of these cells was impaired in association with impaired bone morphogenetic protein (BMP) signaling. In vivo ectopic bone-formation assays and in vitro investigations in ST2 stromal cells confirmed that phosphate restriction leads to BMP-2 resistance. Marrow ablation studies demonstrate that hypophosphatemia has different effects on injury-induced intramembranous bone formation compared with endochondral bone formation. Thus phosphate plays an important role in the skeleton that extends beyond mineralized matrix formation and growth plate maturation and is critical for endochondral bone repair. © 2010 American Society for Bone and Mineral Research.

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Section: Discussionmentioning

confidence: 99%

“…(26) Furthermore, BMPs have been used to promote healing of fractures, including those that exhibit nonunion, a pathologic condition associated with failure of fracture healing. (27)(28)(29)(30) BMPs also have been shown to have critical roles in the development of other organ systems. (31,32) as well as in limb patterning.…”

Section: Discussionmentioning

confidence: 99%

Acute phosphate restriction leads to impaired fracture healing and resistance to BMP-2

Wigner

Luderer

Cox

et al. 2010

Journal of Bone and Mineral Research

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“…Because PRP is centrifuged from autologous plasma, it has a large number of growth factors [ 15 ]. These growth factors are conducive to promote the proliferation of bone cells, and the formation of new bone after the prosthesis stem is implanted into the medullary cavity, so as to restore bone mineral density and better improve the initial stability of the prosthesis [ 16 ]. However, there are differences on the early fixation effect of biological prosthesis in FNF therapy in the elderly Therefore, in order to further explore the curative effect of cemented and biological prosthesis in the therapy of elderly FNF, we conducted research and discussion, and the results are as follows.…”

Section: Introductionmentioning

confidence: 99%

Effect of nHA-Coated Femoral Stem Prosthesis Combined with Platelet-Rich Plasma in Hemi Hip Replacement of Femoral Neck Fracture in the Elderly

Yang¹,

Wu²,

Liu³

et al. 2022

Computational and Mathematical Methods in Medicine

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Purpose. This study investigated the efficacy of nanohydroxyapatite- (nHA-) coated biological prosthesis combined with platelet-rich plasma (PRP) in hemi hip replacement of femoral neck fracture (FNF) in the elderly. Methods. From September 2018 to September 2021, 102 elderly patients with FNF treated in our hospital were chosen and divided into two groups according to different intervention methods. Fifty-one patients in the bone cement group were treated with bone cement prosthesis, and the rest 51 patients in the observation group were treated with nHA biological prosthesis combined with PRP in hemi hip replacement. In order to explore the osteogenic effect of nHA and PRP, osteoblasts were cultured. Results. It was found that nHA and PRP could both effectively promote the proliferation of osteoblasts and improve their mineralization ability, especially when used in combination. In the course of clinical therapy, we found that the use of biological prosthesis combined with PRP could effectively reduce the level of serum procollagen type I carboxy terminal peptide (PICP) and better improve the levels of bone alkaline phosphatase (BALP) and bone Gla protein (BGP), so as to reduce the bone conversion rate and promote the formation of new bone around the prosthesis. In addition, no significant difference was found in intraoperative bleeding, operation time, hospital stay, 48 h drainage volume, partial weight-bearing time, and complete weight-bearing time between two groups. Otherwise, the use of biological prosthesis could effectively avoid the occurrence of adverse reactions such as bone cement crisis and fracture around femoral prosthesis, so as to better restore the hip function and improve patients’ life quality. Conclusions. Therefore, in hemi hip replacement of FNF in the elderly, nHA biological prosthesis combined with PRP can effectively promote the formation of new bone around the prosthesis stem, so as to obtain good initial stability, enable patients to carry out early weight-bearing exercise, and effectively avoid adverse reactions caused by bone cement prosthesis, thus improving patients’ hip function and life quality.

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“…While some studies in cranial and mandibular defects showed that the addition of PRP to xenografts, alloplastic materials or scaffolds improved bone formation compared to the use of the grafts/scaffolds alone (Aghaloo, Moy & Freymiller, ; Chen, Lu, Liu, Tang & Zhang, ; El Backly, Zaky, Canciani, Saad & Eweida, ; Hirota, Matsui, Mizuki, Kishi & Watanuki, ; Kim, Kim, Kim, Lim & Kim, ; Li, Chen, Wei, Hao & Wang, ; Penteado, Colombo, Penteado, Assis & Gurgel, ; Schlegel et al., ), other studies did not confirm these findings (DeNicolo, Guyton, Cuenin, Hokett & Sharawy, ; Faratzis, Leventis, Chrysomali, Khaldi & Eleftheriadis, ; Plachokova, Dolder, Stoelinga & Jansen, ; Rocha, Ramos, Batista, Zanetta‐Barbosa & Ferro, ; Wiltfang et al., ) or showed that the use of MSCs in conjunction with bone substitutes could enhance bone regeneration more than PRP (Khojasteh, Eslaminejad & Nazarian, ). It was also shown that adding PRP to GBR (Kazakos, Lyras, Thomaidis, Agrogiannis & Botaitis, ) or to BMP (Ferraz, Schellini, Schellini, Pellizon & Hirai, ) did not accelerate the bone formation process.…”

Section: Resultsmentioning

confidence: 99%

The use of bioactive factors to enhance bone regeneration: A narrative review

Donos

Dereka

Calciolari

2019

J Clinic Periodontology

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Aim This review critically appraises the available knowledge on the pre‐clinical and clinical use of bioactive factors for bone regeneration in the cranial and maxillofacial area. Materials and Methods The use of growth factors, amelogenins and autologous platelet concentrates (APCs) for bone regeneration was reviewed in a systematic manner. More specifically, pre‐clinical and clinical studies on ridge preservation, alveolar ridge augmentation, regeneration of peri‐implant defects and sinus augmentation models were considered. Results Amongst different bioactive factors, the highest pre‐clinical and clinical evidence of a positive effect on bone formation is associated with rhBMP‐2 and the lowest with amelogenins. While APCs seem to accelerate clinical healing and reduce postoperative discomfort, there is insufficient and contrasting evidence of a significant effect on hard tissue regeneration for the different clinical applications. Conclusions Although there is increasing evidence that bioactive factors might enhance the bone regeneration process, the great heterogeneity of the available studies and the limited number of RCTs do not allow to draw robust conclusions. Issues that still need to be investigated include the optimal carriers for bioactive agents (direct vs. indirect), the dosage, the timing of administration, as well as the possibility of combining different agents to promote synergistic effects.

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BMP Implant Associated with Platelet-Rich Plasma in Orbit Fracture Repair

Abstract: BMP implant promotes bone induction, integration at fracture site, scarce inflammatory reaction, and may be a good alternative in orbit fracture reconstruction. The addition of PRP to the BMP plate did not accelerate the resolution, and its use is not necessary.

Cited by 7 publications

References 26 publications

Acute phosphate restriction leads to impaired fracture healing and resistance to BMP-2

Acute phosphate restriction leads to impaired fracture healing and resistance to BMP-2

Effect of nHA-Coated Femoral Stem Prosthesis Combined with Platelet-Rich Plasma in Hemi Hip Replacement of Femoral Neck Fracture in the Elderly

The use of bioactive factors to enhance bone regeneration: A narrative review

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