BMP9 maintains the phenotype of HTR-8/Svneo trophoblast cells by activating the SDF1/CXCR4 pathway

Yang, Xue; Ren, Lingling; Chen, Xiang; Pang, Ying; Jia, Baoxia; Sun, Jing; Quan, Xiaofang

doi:10.1186/s12860-023-00487-0

Cited by 3 publications

(1 citation statement)

References 45 publications

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“…It has been demonstrated that bone morphogenetic protein 9 (BMP9) regulates the processes involved in endothelial dysfunction ( Long et al, 2015 ). Yang and others ( Yang et al, 2023 ) revealed that serum from PE patients had lower levels of CXCL12 and CXCR4 expression and that there was a positive correlation between BMP9 and these expression levels. In HTR-8/SVneo cells, overexpression of BMP9 increased the levels of CXCL12 and CXCR4.…”

Section: Role Of CXC Chemokines In the Pathogenesis Of Pementioning

confidence: 97%

Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus

Ullah,

Zhao,

Singla

et al. 2023

Front. Cell Dev. Biol.

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Diabetes-related pathophysiological alterations and various female reproductive difficulties were common in pregnant women with gestational diabetes mellitus (GDM), who had 21.1 million live births. Preeclampsia (PE), which increases maternal and fetal morbidity and mortality, affects approximately 3%–5% of pregnancies worldwide. Nevertheless, it is unclear what triggers PE and GDM to develop. Therefore, the development of novel moderator therapy approaches is a crucial advancement. Chemokines regulate physiological defenses and maternal-fetal interaction during healthy and disturbed pregnancies. Chemokines regulate immunity, stem cell trafficking, anti-angiogenesis, and cell attraction. CXC chemokines are usually inflammatory and contribute to numerous reproductive disorders. Fractalkine (CX3CL1) may be membrane-bound or soluble. CX3CL1 aids cell survival during homeostasis and inflammation. Evidence reveals that CXC and CX3CL1 chemokines and their receptors have been the focus of therapeutic discoveries for clinical intervention due to their considerable participation in numerous biological processes. This review aims to give an overview of the functions of CXC and CX3CL1 chemokines and their receptors in the pathophysiology of PE and GDM. Finally, we examined stimulus specificity for CXC and CX3CL1 chemokine expression and synthesis in PE and GDM and preclinical and clinical trials of CXC-based PE and GDM therapies.

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Section: Role Of CXC Chemokines In the Pathogenesis Of Pementioning

confidence: 97%

Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus

Ullah,

Zhao,

Singla

et al. 2023

Front. Cell Dev. Biol.

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Bone morphogenetic protein-9 downregulates StAR expression by inducing snail expression via SMAD1/5/8 signaling in human granulosa-lutein cells

Liu,

Fu,

Zhou

et al. 2024

Molecular and Cellular Endocrinology

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Inhibitor of DNA Binding Protein 2 (ID2) Mediates the Anti-Proliferative and Pro-Differentiation Effects of Insulin-like Growth Factor-1 (IGF-1)

Ssengonzi,

Wang,

Zhou

et al. 2024

Life

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In preeclampsia (PE), impaired trophoblast proliferation and differentiation are thought to cause abnormal placentation and subsequent clinical manifestations of the disease, i.e., hypertension, proteinuria, and end-organ damage. Insulin-like growth factor-1 (IGF-1) influences trophoblast cell function; however, the mechanism of IGF-1’s action on trophoblasts is not understood well. Inhibitor of DNA binding protein 2 (ID2) is involved in trophoblast differentiation and implicated in many processes disrupted in PE, including placental development, vascular differentiation, and angiogenesis. We hypothesized that IGF-1 regulates trophoblast proliferation and differentiation via ID2. Immortalized human first trimester trophoblast cells (HTR-8/SVneo) were treated with IGF-1 for 24 h after serum starvation. ID2 mRNA and protein were measured, as well as trophoblast cell viability, proliferation, tube formation, and migration. IGF-1 decreased ID2 expression in a dose-dependent manner. IGF-1 decreased trophoblast proliferation but increased cell viability, differentiation, and migration. ID2 overexpression mitigated the effects of IGF-1 on trophoblast cells. These data suggest that IGF-1 could regulate trophoblast proliferation and differentiation through ID2. The dysregulation of ID2-mediated IGF-1 signaling in trophoblast cells could be involved in the pathogenesis of pregnancy disorders like uterine growth restriction and PE.

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BMP9 maintains the phenotype of HTR-8/Svneo trophoblast cells by activating the SDF1/CXCR4 pathway

Cited by 3 publications

References 45 publications

Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus

Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus

Bone morphogenetic protein-9 downregulates StAR expression by inducing snail expression via SMAD1/5/8 signaling in human granulosa-lutein cells

Inhibitor of DNA Binding Protein 2 (ID2) Mediates the Anti-Proliferative and Pro-Differentiation Effects of Insulin-like Growth Factor-1 (IGF-1)

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