BMSC‑derived exosome‑mediated miR‑25‑3p delivery protects against myocardial ischemia/reperfusion injury by constraining M1‑like macrophage polarization

Du, Jingxia; Dong, Yibo; Song, Jingjing; Shui, Hanqi; Xiao, Chengyao; Hu, Yue; Zhou, Shiyao; Wang, Shanshan

doi:10.3892/mmr.2024.13266

Mol Med Rep

2024

DOI: 10.3892/mmr.2024.13266

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BMSC‑derived exosome‑mediated miR‑25‑3p delivery protects against myocardial ischemia/reperfusion injury by constraining M1‑like macrophage polarization

Jingxia Du,

Yibo Dong,

Jingjing Song

et al.

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Cited by 4 publications

References 73 publications

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Exosomes and Macrophages: Bidirectional Mutual Regulation in the Treatment of Diabetic Complications

Li,

Yang,

et al. 2024

Cel. Mol. Bioeng.

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Exosomes and Macrophages: Bidirectional Mutual Regulation in the Treatment of Diabetic Complications

Li,

Yang,

et al. 2024

Cel. Mol. Bioeng.

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Emerging role of sphingolipids and extracellular vesicles in development and therapeutics of cardiovascular diseases

Bhat,

Mir,

Nehvi

et al. 2024

IJC Heart & Vasculature

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The immune regulatory role of exosomal miRNAs and their clinical application potential in heart failure

Guo,

Yan,

Yang

et al. 2024

Front. Immunol.

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Heart failure (HF) is a complex and debilitating condition characterized by the heart’s inability to pump blood effectively, leading to significant morbidity and mortality. The abnormality of immune response is a key factor in the progression of HF, contributing to adverse cardiac remodeling and dysfunction. Exosomal microRNAs (miRNAs) play a pivotal role in regulating gene expression and cellular function, which are integral to the crosstalk between cardiac and immune cells, influencing immune cell functions, such as macrophage polarization, T cell activity, and cytokine production, thereby modulating various pathological processes of HF, such as inflammation, fibrosis, and cardiac dysfunction. This review emphasizes the immune-regulatory role of exosomal miRNAs in HF and highlights their clinical potential as diagnostic biomarkers and therapeutic agents.

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BMSC‑derived exosome‑mediated miR‑25‑3p delivery protects against myocardial ischemia/reperfusion injury by constraining M1‑like macrophage polarization

Cited by 4 publications

References 73 publications

Exosomes and Macrophages: Bidirectional Mutual Regulation in the Treatment of Diabetic Complications

Exosomes and Macrophages: Bidirectional Mutual Regulation in the Treatment of Diabetic Complications

Emerging role of sphingolipids and extracellular vesicles in development and therapeutics of cardiovascular diseases

The immune regulatory role of exosomal miRNAs and their clinical application potential in heart failure

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