Body composition analysis as an indirect marker of skeletal muscle mass in Huntington's disease

Cubo, Esther; Rivadeneyra, J; Gil‐Polo, Cecilia; Armesto, Diana; Cachorro, Ana Mateos; Mariscal-Pérez, Natividad

doi:10.1016/j.jns.2015.09.351

Cited by 11 publications

(5 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This article proposes several hypotheses to understand the lack of significant muscle wasting in our PD sample. Firstly, muscle wasting could be prevented by an adequate energy dietary intake and a Mediterranean dietary pattern 43,44 . In fact, none of our patients were underweight.…”

Section: Discussionmentioning

confidence: 84%

The Impact of Dietary Intake and Physical Activity on Body Composition in Parkinson's Disease

Rivadeneyra

Verhagen

Bartulos

et al. 2021

Movement Disord Clin Pract

Self Cite

View full text Add to dashboard Cite

Background Skeletal muscle loss has been associated with declining physical performance and a negative prognostic effect on falls, disability, and mortality risk in Parkinson's disease. Objectives We aimed to analyze the clinical correlates associated with skeletal muscle wasting in Parkinson's disease. Methods This was a cross‐sectional, case–control, observational study. We collected information on dietary intake with a 24‐hour recall questionnaire, body composition with bioelectrical impedance, motor severity with the Unified Parkinson's disease Rating Scale, and physical activity with the Global Physical Activity Questionnaire. We used multivariate linear regression analysis to analyze the sociodemographic and clinical correlates associated with skeletal muscle loss after adjusting for confounding variables. Results Forty‐three patients with Parkinson's disease and 21 matched family members were included. Patients and family members had similar body composition, anthropometrics, and nutritional parameters. Advanced patients had similar nutrient intakes compared to patients with mild‐to‐moderate Parkinson's disease. In the multivariate linear regression analysis, female patients with low physical activity and low energy intake were more likely to have skeletal muscle loss. Conclusions Skeletal muscle wasting is a complex multifactorial problem. Dietary strategies and physical exercise should be recommended, especially to females with Parkinson's disease, to prevent significant skeletal muscle wasting.

show abstract

Section: Discussionmentioning

confidence: 84%

The Impact of Dietary Intake and Physical Activity on Body Composition in Parkinson's Disease

Rivadeneyra

Verhagen

Bartulos

et al. 2021

Movement Disord Clin Pract

Self Cite

View full text Add to dashboard Cite

show abstract

“…Skeletal muscle atrophy is supposed to be a primary health risk in HD patients 33. However, several cross-sectional studies in early- and mid-stage HD patients could not detect significant differences in fat-free mass or lean mass in comparison to age-matched healthy controls 31,34–36. These studies highlighted that observed alterations in muscle mass in HD patients rely on a multitude of factors, e.g.…”

Section: Discussionmentioning

confidence: 97%

Exercise in Huntington’s Disease: Current State and Clinical Significance

Mueller

Petersen

Jung

2019

Tremor and Other Hyperkinetic Movements

View full text Add to dashboard Cite

BackgroundHuntington’s disease (HD) is a rare, progressive neurodegenerative disease. Currently, there is no cure for the disease, but treatment may alleviate HD symptoms. In recent years, several exercise training interventions have been conducted in HD patients. In the current article, we review previous studies investigating targeted exercise training interventions in HD patients.MethodsWe performed a literature search using the PubMed, Scopus, Web of Science, and Google Scholar databases on exercise training interventions in HD patients. Six publications fulfilled the criteria and were included in the review.ResultsExercise training resulted in beneficial effects on cardiovascular and mitochondrial function. Training effects on cognition, motor function, and body composition were less congruent, but a positive effect seems likely. Health-related quality of life during the training interventions was stable. Most studies reported no related adverse events in response to training.DiscussionExercise training seems to be safe and feasible in HD patients. However, current knowledge is mainly based on short, small-scale studies and it cannot be transferred to all HD patients. Therefore, longer-term interventions with larger HD patient cohorts are necessary to draw firm conclusions about the potentially positive effects of exercise training in HD patients.

show abstract

“…HD patients show skeletal muscle weakness and signs of peripheral motor pathology, such as defects in eye movements and swallowing, gait abnormalities, reduced lower limb muscle strength, and dysarthria [34][35][36]. Changes in body composition and muscle wasting were not detected in a cohort of HD patients with early-to-moderate symptoms [37]. However, reduction of lean and fat body mass was reported in other HD patient cohorts as an early phenomenon [38].…”

Section: Muscle Pathology In Polyglutamine Disease Patientsmentioning

confidence: 88%

Skeletal Muscle Pathogenesis in Polyglutamine Diseases

Marchioretti

Zuccaro

Pandey

et al. 2022

Cells

View full text Add to dashboard Cite

Polyglutamine diseases are characterized by selective dysfunction and degeneration of specific types of neurons in the central nervous system. In addition, nonneuronal cells can also be affected as a consequence of primary degeneration or due to neuronal dysfunction. Skeletal muscle is a primary site of toxicity of polyglutamine-expanded androgen receptor, but it is also affected in other polyglutamine diseases, more likely due to neuronal dysfunction and death. Nonetheless, pathological processes occurring in skeletal muscle atrophy impact the entire body metabolism, thus actively contributing to the inexorable progression towards the late and final stages of disease. Skeletal muscle atrophy is well recapitulated in animal models of polyglutamine disease. In this review, we discuss the impact and relevance of skeletal muscle in patients affected by polyglutamine diseases and we review evidence obtained in animal models and patient-derived cells modeling skeletal muscle.

show abstract

Body composition analysis as an indirect marker of skeletal muscle mass in Huntington's disease

Cited by 11 publications

References 17 publications

The Impact of Dietary Intake and Physical Activity on Body Composition in Parkinson's Disease

The Impact of Dietary Intake and Physical Activity on Body Composition in Parkinson's Disease

Exercise in Huntington’s Disease: Current State and Clinical Significance

Skeletal Muscle Pathogenesis in Polyglutamine Diseases

Contact Info

Product

Resources

About