Body Composition and COPD: A New Perspective

Wang, Xin; Liang, Qianqian; Li, Zheng; Li, Fengsen

doi:10.2147/copd.s394907

Cited by 17 publications

(10 citation statements)

References 119 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Wang and colleagues conducted a study in 2023 [22], con rming the protective and preventive effect of weight gain and obesity on exacerbations, and weight loss leading to deterioration of lung function. Another cross-sectional study [23] of COPD patients suffering from weight gain and obesity showed a protective role in exacerbating the morbidity rate among patients [24].…”

Section: Discussionmentioning

confidence: 95%

Correlation between gastroesophageal reflux disease (GERD) and the risk of acute exacerbation of chronic obstructive pulmonary disease (COPD), A cross-sectional study in Syrian Patients

Al-Sawaf,

Nakhleh,

Al-Bardan

2024

Preprint

View full text Add to dashboard Cite

Background: Gastroesophageal reflux disease (GERD) and chronic obstructive pulmonary disease (COPD) are prevalent chronic conditions associated with significant morbidity and mortality worldwide. While GERD affects 10-20% of adults in Western countries, COPD affects approximately 10% of adults over 40 years old. The coexistence of GERD and COPD is increasingly recognized, with evidence suggesting a bidirectional relationship between the two conditions. Methods: A cross-sectional study was conducted on a sample of residents from various provinces in Syria (Damascus, Al-Suwayda, Raqqa, Deir ez-Zor, Daraa), with informed consent obtained from all participants. The inclusion criteria encompassed all participants who responded to the questionnaire within the period from February 1st to March 25th, 2024. Results: The survey involved 100 COPD patients from various Syrian regions, mostly Damascus (82%), with 76% male and 24% female, averaging 64.5 years. 75% lacked education, 63% were employed in diverse fields. Smoking rate was 89%, with 98% married and 3 children on average. 50% had high blood pressure, 28% previously diagnosed with COPD. 86% struggled to quit smoking. 60% had three meals daily. Conclusions: The study assessed 100 participants with COPD from various Syrian regions, predominantly Damascus (82%). It found 48% had normal BMI, while 68% were male smokers, despite awareness campaigns. Elderly participants (aged 70-61) were prevalent, potentially experiencing comorbidities such as hypertension and cardiac disorders. 40% reported acid reflux, correlated with dietary neglect. There was no significant gender correlation with GERD, but age showed a weak association. Smoking exacerbated COPD symptoms, with increased consumption leading to worsened prognosis. Male gender potentially protected against severe exacerbations. Participants within the normal weight range (48%) faced increased hospitalization risks due to severe exacerbations. Studies emphasized weight gain and obesity's protective role against exacerbations and morbidity rates among COPD patients.

show abstract

Section: Discussionmentioning

confidence: 95%

Correlation between gastroesophageal reflux disease (GERD) and the risk of acute exacerbation of chronic obstructive pulmonary disease (COPD), A cross-sectional study in Syrian Patients

Al-Sawaf,

Nakhleh,

Al-Bardan

2024

Preprint

View full text Add to dashboard Cite

show abstract

“…However, these findings are consistent with the observation that a lower BMI in patients with COPD is a marker of clinically severe disease and greater mortality than patients with a greater BMI. 44 Our study has a number of notable strengths. This is the one of the largest studies to date to directly measure individualized, in-home NO 2 concentrations in people with COPD.…”

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Pulmonary, inflammatory, and oxidative effects of indoor nitrogen dioxide in patients with COPD

McHugh,

Grady,

Collins

et al. 2023

Environmental Epidemiology

View full text Add to dashboard Cite

Introduction: Indoor nitrogen dioxide (NO2) sources include gas heating, cooking, and infiltration from outdoors. Associations with pulmonary function, systemic inflammation, and oxidative stress in patients with chronic obstructive pulmonary disease (COPD) are uncertain. Methods: We recruited 144 COPD patients at the VA Boston Healthcare System between 2012 and 2017. In-home NO2 was measured using an Ogawa passive sampling badge for a week seasonally followed by measuring plasma biomarkers of systemic inflammation (C-reactive protein [CRP] and interleukin-6 [IL-6]), urinary oxidative stress biomarkers (8-hydroxy-2'deoxyguanosine [8-OHdG] and malondialdehyde [MDA]), and pre- and postbronchodilator spirometry. Linear mixed effects regression with a random intercept for each subject was used to assess associations with weekly NO2. Effect modification by COPD severity and by body mass index (BMI) was examined using multiplicative interaction terms and stratum-specific effect estimates. Results: Median (25%ile, 75%ile) concentration of indoor NO2 was 6.8 (4.4, 11.2) ppb. There were no associations observed between NO2 with CRP, 8-OHdG, or MDA. Although the confidence intervals were wide, there was a reduction in prebronchodilator FEV1 and FVC among participants with more severe COPD (FEV1: –17.36 mL; –58.35, 23.60 and FVC: –28.22 mL; –91.49, 35.07) that was greater than in patients with less severe COPD (FEV1: –1.64 mL; –24.80, 21.57 and FVC: –6.22 mL; –42.16, 29.71). In participants with a BMI <30, there was a reduction in FEV1 and FVC. Conclusions: Low-level indoor NO2 was not associated with systemic inflammation or oxidative stress. There was a suggestive association with reduced lung function among patients with more severe COPD and among patients with a lower BMI.

show abstract

“…COPD is influenced by various risk factors, including age, gender, genetics, and lifestyle-related factors such as smoking, air pollution, occupational exposures, socioeconomic status, immune response, inflammation, and BMI [26]. Among these factors, smoking is the primary and most significant risk factor for COPD as it is associated with pulmonary vascular endothelial cell apoptosis in COPD pathogenesis [27].…”

Section: Discussionmentioning

confidence: 99%

Impact of Lung-Related Polygenic Risk Scores on Chronic Obstructive Pulmonary Disease Risk and Their Interaction with w-3 Fatty Acid Intake in Middle-Aged and Elderly Individuals

Kim

Park

2023

Nutrients

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD) is a complex, progressive respiratory disorder with persistent airflow limitation and tissue destruction. We aimed to explore the genetic impact of COPD and its interaction with nutrient intake in 8840 middle-aged and elderly individuals from the Ansan/Ansung cohorts. Participants were diagnosed with COPD if the ratio of forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) was less than 0.7 using spirometry, and if they were previously diagnosed with COPD by a physician. Genome-wide association studies (GWAS) were performed to screen for genetic variants associated with COPD risk. Among them, we selected the genetic variants that exhibited interactions using the generalized multifactor dimensionality reduction (GMDR) method. The polygenic risk score (PRS) was computed by summing the number of risk alleles in the SNP-SNP interaction models that adhered to specific rules. Subsequently, participants were categorized into low-PRS, medium-PRS, and high-PRS groups. The participants with COPD exhibited significantly lower FEV1/FVC ratios (0.64) than those without COPD (0.82). It was positively associated with inflammation markers (serum C-reactive protein and white blood cell levels). A higher proportion of COPD participants were smokers and engaged in regular exercise. The 5-SNP model consisted of FAM13A_rs1585258, CAV1_rs1997571, CPD_rs719601, PEPD_rs10405598, and ITGA1_rs889294, and showed a significant association with COPD risk (p < 0.001). Participants in the high-PRS group of this model had a 2.2-fold higher risk of COPD than those in the low-PRS group after adjusting for covariates. The PRS interacted with w-3 fatty acid intake and exercise, thus influencing the risk of COPD. There was an increase in COPD incidence among individuals with a higher PRS, particularly those with low consumption of w-3 fatty acid and engaged in high levels of exercise. In conclusion, adults with a high-PRS are susceptible to COPD risk, and w-3 fatty acid intake and exercise may impact the risk of developing COPD, potentially applying to formulate precision medicines to prevent COPD.

show abstract

Body Composition and COPD: A New Perspective

Cited by 17 publications

References 119 publications

Correlation between gastroesophageal reflux disease (GERD) and the risk of acute exacerbation of chronic obstructive pulmonary disease (COPD), A cross-sectional study in Syrian Patients

Correlation between gastroesophageal reflux disease (GERD) and the risk of acute exacerbation of chronic obstructive pulmonary disease (COPD), A cross-sectional study in Syrian Patients

Pulmonary, inflammatory, and oxidative effects of indoor nitrogen dioxide in patients with COPD

Impact of Lung-Related Polygenic Risk Scores on Chronic Obstructive Pulmonary Disease Risk and Their Interaction with w-3 Fatty Acid Intake in Middle-Aged and Elderly Individuals

Contact Info

Product

Resources

About