Body Composition Changes Following Dialysis Initiation and Cardiovascular and Mortality Outcomes in CRIC (Chronic Renal Insufficiency Cohort): A Bioimpedance Analysis Substudy

Wang, Ke; Zelnick, Leila R.; Chertow, Glenn M.; Himmelfarb, Jonathan; Bansal, Nisha

doi:10.1016/j.xkme.2020.12.008

Cited by 9 publications

(3 citation statements)

References 49 publications

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“…PhA is directly calculated from the electrical components of resistance (R) and reactance (Xc) and is converted from radians to degrees as the arc tangent of the reactance-to-resistance ratio. A close correlation between nutritional status and PhA has been demonstrated in several studies [ 23 ]; therefore, PhA was used as a marker of nutritional status in our study.…”

Section: Methodsmentioning

confidence: 53%

Interaction Effect of Phase Angle and Age on Femoral Neck Bone Mineral Density in Patients with Non-Dialysis Chronic Kidney Disease Stage 5

et al. 2023

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Background: Low bone mass is common in malnourished patients with chronic kidney disease (CKD) and can lead to a higher risk of fractures. Elderly and CKD patients have the same risk factors for protein-energy wasting, sarcopenia, and osteoporosis. Here, we investigated the association between phase angle (PhA) and bone mineral density (BMD) in dialysis-naïve patients with CKD stage 5 (CKD5) and identified a statistical relationship between PhA and age, which affects bone density. Methods: Bio-impedance spectroscopy for evaluating body composition and PhA and dual-energy X-ray absorptiometry for determining the BMD were simultaneously performed in 167 consecutive patients (mean age, 59.65 ± 13.98 years; women, 40.1%). Two-way analysis of variance (ANOVA) was conducted to assess the potential interaction effect of PhA and age on femoral neck BMD (FN-BMD). Results: Our results showed that PhA and age were independently associated with FN-BMD and T-score in multiple linear regressions analyses. A significant interaction effect of PhA and age on FN-BMD was found on two-way ANOVA (p = 0.028). The average BMD values for the first and second tertiles of the PhA were higher in the young versus elderly group, whereas patients in the elderly group had higher BMD in the third tertiles. Conclusions: A relationship was noted between PhA and BMD in patients with advanced-stage CKD. The effect of PhA level on FN-BMD differed between elderly and young patients. Our study suggested that higher PhA levels could be a marker explaining the maintenance of good bone health in elderly patients with CKD5. Further longitudinal analyses are needed to determine whether PhA predicts the risk of CKD-MBD-related fractures during CKD progression.

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Section: Methodsmentioning

confidence: 53%

Interaction Effect of Phase Angle and Age on Femoral Neck Bone Mineral Density in Patients with Non-Dialysis Chronic Kidney Disease Stage 5

et al. 2023

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“…Survival analyses significantly showed that age > 72 years PhA ≤ 4° were associated with an increased risk of mortality [ 44 ]. In a multicenter cohort study involving 427 pre-dialysis patients (mean GFR, 7.0 ± 8.7 mL/min/1.73 m 2 ), the PhA decreased by a mean of 0.6 degrees as patients transitioned to dialysis, but this change was not associated with the risk of heart failure, stroke, myocardial infarction, or all-cause mortality [ 45 ]. Thus, more studies are needed to confirm the predictive power of PhA for clinical outcomes when disease stages change in CKD patients.…”

Section: Resultsmentioning

confidence: 99%

Application of Bioelectrical Impedance Analysis in Nutritional Management of Patients with Chronic Kidney Disease

Guo,

Zhang,

et al. 2023

Nutrients

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Body composition measurement plays an important role in the nutritional diagnosis and treatment of diseases. In the past 30 years, the detection of body composition based on bioelectrical impedance analysis (BIA) has been widely used and explored in a variety of diseases. With the development of technology, bioelectrical impedance analysis has gradually developed from single-frequency BIA (SF-BIA) to multi-frequency BIA (multi-frequency BIA, MF-BIA) and over a range of frequencies (bioimpedance spectroscopy, BIS). As the clinical significance of nutrition management in chronic kidney disease has gradually become prominent, body composition measurement by BIA has been favored by nephrologists and nutritionists. In the past 20 years, there have been many studies on the application of BIA in patients with CKD. This review describes and summarizes the latest research results of BIA in nutritional management of patients with CKD including pre-dialysis, hemodialysis, peritoneal dialysis and kidney transplantation, in order to provide reference for the application and research of BIA in nutritional management of chronic kidney disease in the future.

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“…Survival analyses significantly showed that age＞72 years PhA ≤4°were associated with an increased risk of mortality [44]. In a multicenter cohort study involving 427 pre-dialysis patients (mean GFR, 7.0±8.7 mL/minute/1.73 m 2 ), the PhA decreased by a mean of 0.6 degrees as patients transitioned to dialysis, but this change was not associated with the risk of heart failure, stroke, myocardial infarction, or all-cause mortality [45].…”

Section: ) Phase Anglementioning

confidence: 99%

Application of bioelectrical impedance analysis in nutritional management of patients with chronic kidney disease

Guo,

Zhang,

et al. 2023

Preprint

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Body composition measurement plays an important auxiliary role in the nutritional assessment of diseases, nutritional diagnosis and the evaluation of the effect of nutritional therapy. There are many techniques and methods available for the measurement of body composition. Bioelectrical impedance analysis (BIA ) of body composition has been widely used and explored in many diseases in the past 30 years. Its main advantages are its non-invasiveness, non-radiation, economy, convenience and feasibility. With the development of bioelectrical impedance technology, bioelectrical impedance analysis has gradually developed from single-frequency BIA (SF-BIA) to dual-frequency BIA (DF-BIA). now devices are available that measure at multiple ﬁxed frequencies (multi-frequency BIA, MF-BIA) and over a range of frequencies (bioimpedance spectroscopy, BIS). The clinical significance of nutrition management in chronic kidney disease has gradually become prominent. Bioelectrical impedance analysis of body composition is favored by nephrologists and nutritionists as an auxiliary method for nutrition diagnosis, treatment and monitoring. In the past 20 years, there have been many studies on body composition measurement by bioelectrical impedance analysis in the nutritional management of CKD patients. This article will summarize the recent research results of BIA of body composition method in the nutrition management of CKD patients in pre-dialysis, hemodialysis, peritoneal dialysis and kidney transplantation, in order to provide reference for the application and research of BIA method in the nutrition management of chronic kidney disease in the future.

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Body Composition Changes Following Dialysis Initiation and Cardiovascular and Mortality Outcomes in CRIC (Chronic Renal Insufficiency Cohort): A Bioimpedance Analysis Substudy

Cited by 9 publications

References 49 publications

Interaction Effect of Phase Angle and Age on Femoral Neck Bone Mineral Density in Patients with Non-Dialysis Chronic Kidney Disease Stage 5

Interaction Effect of Phase Angle and Age on Femoral Neck Bone Mineral Density in Patients with Non-Dialysis Chronic Kidney Disease Stage 5

Application of Bioelectrical Impedance Analysis in Nutritional Management of Patients with Chronic Kidney Disease

Application of bioelectrical impedance analysis in nutritional management of patients with chronic kidney disease

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