“…There is an inverse relationship between initial body fat mass and the proportion of weight loss from FFM, which could explain why men, who generally have less body fat (and more FFM or SMM) than women, usually have a greater proportion of weight loss from FFM and SMM than women. The proportion of weight loss from FFM is directly associated with total weight loss, but the influence of this effect is attenuated in people with obesity and the proportion of weight loss from FFM is similar across a wide range (5%-35%) of weight loss . The decrease in FFM is primarily responsible for the decrease in basal metabolic rate that occurs after weight loss.…”
This Viewpoint explores the effects of weight loss achieved through GLP-1–based antiobesity medications on weight regain, fat-free mass, and skeletal muscle mass in people with obesity.
“…There is an inverse relationship between initial body fat mass and the proportion of weight loss from FFM, which could explain why men, who generally have less body fat (and more FFM or SMM) than women, usually have a greater proportion of weight loss from FFM and SMM than women. The proportion of weight loss from FFM is directly associated with total weight loss, but the influence of this effect is attenuated in people with obesity and the proportion of weight loss from FFM is similar across a wide range (5%-35%) of weight loss . The decrease in FFM is primarily responsible for the decrease in basal metabolic rate that occurs after weight loss.…”
This Viewpoint explores the effects of weight loss achieved through GLP-1–based antiobesity medications on weight regain, fat-free mass, and skeletal muscle mass in people with obesity.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.