2020
DOI: 10.1111/cen.14331
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Body composition in women with premature ovarian insufficiency using hormone therapy and the relation to cardiovascular risk markers: A case‐control study

Abstract: In women with premature ovarian insufficiency (POI), ovarian function is impaired prior to forty years of age, with a loss of ovarian reserve and a reduction in the production of sex steroids. 1-3 The condition of early hypoestrogenism clinically manifests as irregular menstrual cycles with primary or secondary amenorrhoea, expressed as hypergonadotropic hypogonadism, with FSH levels above 25 IU/L. 1,2 This condition affects

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Cited by 9 publications
(12 citation statements)
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“…Our study’s finding of lower muscle mass including ALM and ALMI in women with s-POI or i-POI is consistent with results from Luo et al, which reported a lower muscle distributing coefficient of the lower limbs (MD) in 240 women with POI compared with peri- or postmenopausal women, not on ERT ( 43 ). This contrasts with the case-control study of 140 participants by Freitas et al, which did not observe any difference in the TFM or TLM in women with POI ( 44 ); however, the use of ERT for 18 months by these participants may have prevented muscle loss. Similarly, in the longitudinal analysis of our POI cohort, an increase in lean mass (ALM, ALMI) was observed in those with continued ERT use over the follow-up period.…”
Section: Discussioncontrasting
confidence: 76%
“…Our study’s finding of lower muscle mass including ALM and ALMI in women with s-POI or i-POI is consistent with results from Luo et al, which reported a lower muscle distributing coefficient of the lower limbs (MD) in 240 women with POI compared with peri- or postmenopausal women, not on ERT ( 43 ). This contrasts with the case-control study of 140 participants by Freitas et al, which did not observe any difference in the TFM or TLM in women with POI ( 44 ); however, the use of ERT for 18 months by these participants may have prevented muscle loss. Similarly, in the longitudinal analysis of our POI cohort, an increase in lean mass (ALM, ALMI) was observed in those with continued ERT use over the follow-up period.…”
Section: Discussioncontrasting
confidence: 76%
“…Meta-analysis of 25 studies, involving 771 patients with Turner syndrome, showed that women on oral estrogen replacement therapy had a higher increase in HDL-C levels when compared to transdermal therapy (weighted mean difference 9.33 mg/dl [95% CI 4.82-13.85]), with no significant effect on other lipid fractions [26]. The body composition of women with POI using HRT is similar to that of women with normal ovarian function with regard to lean and fat mass content and fat distribution [18].…”
Section: Metabolic Effects Of Hrt In Women With Poimentioning
confidence: 99%
“…Several case-control studies have shown that women with POI have increased waist circumference and increased waistto-hip ratio compared to premenopausal age-matched controls [11,[15][16][17], despite frequently having a lower overall BMI [11]. In women with POI taking HRT, changes in body composition were less marked, with no significant differences in lean and fat mass content or waist-to-hip ratio seen compared to controls [18].…”
Section: Body Compositionmentioning
confidence: 99%
“…Young women with hypogonadism are also at increased risk of reduced BMD, and a number of studies have investigated the effect of earlier age at menopause on osteoporosis outcomes (Alici-Davutoglu et al, 2013b;Freitas et al, 2021;Podfigurna et al, 2020b). Women with early menopause have 1.5~3.0 times higher risk of fracture than women with menopause at the age of 49~55years (Hadji et al, 2019).…”
Section: Introductionmentioning
confidence: 99%