Body fluid-derived stem cells — an untapped stem cell source in genitourinary regeneration

Huang, Ru‐Lin; Li, Qingfeng; Ma, Jian-Xing; Atala, Anthony; Zhang, Yuanyuan

doi:10.1038/s41585-023-00787-2

Cited by 12 publications

(3 citation statements)

References 294 publications

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“…UDSCs are part of the group of body fluid-derived stem cells (BFDSCs). They offer an alternative to solid tissue-derived stem cells by also presenting characteristics of stemness, including self-renewal properties, the expression of stem cell surface markers, and multi-differentiation potential ( Huang et al, 2023 ). BFDSCs encompasses different cell types that can be obtained from diverse sources, such as urine ( Lang et al, 2013 ), synovial fluid ( Li F. et al, 2020 ), menstrual fluid ( Bozorgmehr et al, 2020 ), umbilical cord blood ( Nguyen et al, 2022 ), peripheral blood ( Pouryazdanpanah et al, 2018 ), breast milk ( Mane et al, 2022 ), among others.…”

Section: Current Challenges In Brain Disease Modeling and The Emergen...mentioning

confidence: 99%

“…In comparison with solid tissue-derived stem cells, BFDSCs collection is less invasive, and their isolation tends to be simpler. It bypasses the commonly used enzymatic digestion, which is otherwise applied to separate the desired cells from the extracellular matrix, using instead straightforward methods such as centrifugations to isolate the target cells fraction ( Jia et al, 2018 ; Liu et al, 2018 ; Huang et al, 2023 ). Importantly, BFDSCs have shown significant therapeutic potential, aligning with their intrinsic biological properties.…”

Section: Current Challenges In Brain Disease Modeling and The Emergen...mentioning

confidence: 99%

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Urine-derived stem cells in neurological diseases: current state-of-the-art and future directions

Cavaleiro,

Afonso,

Oliveira

et al. 2023

Front. Mol. Neurosci.

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Stem cells have potential applications in the field of neurological diseases, as they allow for the development of new biological models. These models can improve our understanding of the underlying pathologies and facilitate the screening of new therapeutics in the context of precision medicine. Stem cells have also been applied in clinical tests to repair tissues and improve functional recovery. Nevertheless, although promising, commonly used stem cells display some limitations that curb the scope of their applications, such as the difficulty of obtention. In that regard, urine-derived cells can be reprogrammed into induced pluripotent stem cells (iPSCs). However, their obtaining can be challenging due to the low yield and complexity of the multi-phased and typically expensive differentiation protocols. As an alternative, urine-derived stem cells (UDSCs), included within the population of urine-derived cells, present a mesenchymal-like phenotype and have shown promising properties for similar purposes. Importantly, UDSCs have been differentiated into neuronal-like cells, auspicious for disease modeling, while overcoming some of the shortcomings presented by other stem cells for these purposes. Thus, this review assesses the current state and future perspectives regarding the potential of UDSCs in the ambit of neurological diseases, both for disease modeling and therapeutic applications.

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Section: Current Challenges In Brain Disease Modeling and The Emergen...mentioning

confidence: 99%

Section: Current Challenges In Brain Disease Modeling and The Emergen...mentioning

confidence: 99%

Urine-derived stem cells in neurological diseases: current state-of-the-art and future directions

Cavaleiro,

Afonso,

Oliveira

et al. 2023

Front. Mol. Neurosci.

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show abstract

“…Adult stem cells do not only exist in most tissues and organs but also in human body fluids [ 4 ] . Stem cells can be isolated from various types of amniotic fluid [ 5 ] , synovial fluid [ 6,7 ] , breast milk [ 8 ] , peripheral blood [ 9 ] , menstrual blood [ 10,11 ] , and umbilical cord blood [ 12 ] .…”

Section: Introductionmentioning

confidence: 99%

Power of pee: Urine‐derived stem cells in urological disorders

Opara

Zhang

2023

UroPrecision

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Given that urine-derived stem cells (USCs) originate from the urinary tract system, they hold great potential for treating urological disorders. USCs have several advantages over other types of stem cells, such as easy and noninvasive collection, and abundant supply. USCs can differentiate into different types of cells. This makes them a potential source of cells for tissue engineering and regenerative medicine in the field of urology. In animal models, USCs or USCderived exosomes regenerate damaged tissues in the treatment of various urological disorders such as urinary incontinence, bladder dysfunction, interstitial cystitis, urethra injury erectile dysfunction, and kidney injury via multiple differentiation potential, angiogenesis, anti-inflammatory, paracrine effects, and immune modulation capability. Overall, the use of USCs in urological disorders is a rapidly developing field, and ongoing research is needed to fully understand their potential applications. However, the early results are promising and suggest that USCs could become a valuable cell source for the treatment of various urological disorders in the future.

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Research progress on application of dental stem cells in alveolar bone and periodontal regeneration

Liu,

Guo,

Guo

et al. 2024

MedComm – Future Medicine

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Periodontal disease is a prevalent inflammatory condition affecting the tissues and bone surrounding the teeth, posing significant challenges to oral health. Current treatments often fall short due to incomplete removal of bacteria and plaque, irreversible damage to gums and bone, and their cost and time‐consuming nature. Stem cell therapy offers a promising alternative that potentially addresses these limitations. This review delves into the biology, mechanisms, and applications of dental stem cells (DSCs) in alveolar bone and periodontal regeneration. We begin with an overview of various stem cell types and their characteristics, highlighting their role in tissue regeneration and the mechanisms involved. Subsequently, we examine preclinical and clinical studies that demonstrate the efficacy and safety of DSC therapy, showcasing their potential in restoring periodontal health. The discussion also extends to the critical challenges and future directions in the field, emphasizing the necessity for standardized protocols and rigorous research to fully integrate DSC‐based therapies into routine clinical practice. This review underscores the transformative potential of DSCs in regenerative dentistry, aiming to provide a comprehensive understanding that can propel further advancements and ultimately improve patient outcomes in periodontal therapy.

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Body fluid-derived stem cells — an untapped stem cell source in genitourinary regeneration

Cited by 12 publications

References 294 publications

Urine-derived stem cells in neurological diseases: current state-of-the-art and future directions

Urine-derived stem cells in neurological diseases: current state-of-the-art and future directions

Power of pee: Urine‐derived stem cells in urological disorders

Research progress on application of dental stem cells in alveolar bone and periodontal regeneration

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