Body mass composition among underweight type 2 diabetes mellitus patients—A cross-sectional comparative study

Abstract

Background: Over the past decades, various epidemiological data have shown that the pattern and profile of diabetes mellitus in India are different. The present study was carried out with an aim to study body mass composition in underweight type 2 diabetics and to compare with the normal population. Materials and Methods: The cross-sectional comparative study was conducted between January 2015 and December 2016 and included 60 participants who were selected using the convenient sampling technique. Newly diagnosed patients with type 2 diabetes mellitus and BMI less than 18.5 kg/m 2 were considered for the study. Chi square test and Independent student t test were used for finding the statistically significant difference in proportions and between means, respectively; Pearson correlation coefficient was estimated for finding the linear association between two continuous variables. Results: No statistically significant difference was observed between the two groups in terms of age, waist-hip ratio, and BMI. Higher amount of fat mass and percentage were observed among the patients with diabetes as compared to that of the control group ( P value < 0.05). However, there was no statistically significant difference between the underweight and the control group patients ( P value > 0.05). A significant positive correlation was observed between HbA1c values and body fat mass values ( P value < 0.05). Conclusion: Underweight type 2 diabetic patients were found to have high body fat mass as compared to healthy controls and the HbA1C values of the study participants were found to be positively correlated with fat mass.

Real-world observational study to capture demographic details of newly diagnosed type 2 diabetes mellitus

“…27 In the present study, obese, overweight and surprisingly underweight patients had a higher mean HbA1c compared to patients with normal body mass index, which could been attributed to the lifestyle factors including diet and physical activity and body mass composition. 28 The study results are in concurrence to the fact that smoking is a well-established risk factor for diabetes, which is responsible for the production of reactive oxygen species, protein glycation inflammatory molecules, β-cell dysfunction and end-organ protein damage. 29 In the present study, smokers had a higher HbA1c when compared to non-smokers, which was statistically significant (p<0.0001).…”

Body fat percentage utility over lipid profile as marker of dyslipidemia in type 2 diabetes mellitus

“…This study did not correlate with the study of Garg, Deepika Kumar et al (2019). 6 The cases included by Garg et al were basically underweight with BMI of <18.5 kg/m 2 . Similarly, study by Anjana et al reported that visceral and central abdominal fat was high among diabetic subjects as compared to nondiabetic subjects (P value = 0.005 and 0.011).…”

Indian Phenotype Characteristics Among Patients with Type 2 Diabetes Mellitus: Insights from a Non-interventional Nationwide Registry in India

“…A study from India revealed that despite an insignificant correlation between HbA1c levels and BMI, there was a significant positive correlation between HbA1c and fat mass (r=0.452, p<0.001) in patients with T2D. 16 In addition, a prospective study from India also reported that centrally and peripherally obese subjects with dyslipidaemia had a significant association with HbA1c in T2D. 39 A community-based Korean cohort study demonstrated that, compared with people with a lower BF% (quintile 1), the risk for T2D significantly increased among those with a higher BF% (22.8% in men and 32.9% in women; ≥ quintile 4).…”

“…Previous studies from India have explored the relationship between BMI and BF%; however, there are gaps in evidence, as the studies had a limited sample size. [16][17][18][19][20][21][22][23] In this regard, large-scale registries can provide robust data on IP attributes in people with diabetes.…”