Body mass index and susceptibility to knee osteoarthritis: A systematic review and meta-analysis

Jiang, Liying; Tian, Weijun; Wang, Yingchen; Rong, Jiesheng; Bao, Chundan; Liu, Yupeng; Zhao, Yong; Wang, Chaoxu

doi:10.1016/j.jbspin.2011.05.015

Cited by 285 publications

(193 citation statements)

References 49 publications

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“…For every 5-unit increase in body mass index, the risk of knee OA development increases 35%. 79 Additionally, the link between obesity and hip PTOA has been discussed earlier. Although physical activity is important for overall health, it may compromise joint health after injury.…”

Section: Other Potential Risk Factorsmentioning

confidence: 97%

Epidemiology of Posttraumatic Osteoarthritis

Thomas

Hubbard-Turner

Wikstrom

et al. 2017

Journal of Athletic Training

280

199

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Osteoarthritis is a leading cause of disability whose prevalence and incidence continue to increase. History of joint injury represents an important risk factor for posttraumatic osteoarthritis and is a significant contributor to the rapidly growing percentage of the population with osteoarthritis. This review will present the epidemiology associated with posttraumatic osteoarthritis, with particular emphasis on the knee and ankle joints. It is important to understand the effect of posttraumatic osteoarthritis on the population so that sufficient resources can be devoted to countering the disease and promoting optimal long-term health for patients after joint injury.

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Section: Other Potential Risk Factorsmentioning

confidence: 97%

Epidemiology of Posttraumatic Osteoarthritis

Thomas

Hubbard-Turner

Wikstrom

et al. 2017

Journal of Athletic Training

280

199

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“…Многочисленные работы последовательно проде-монстрировали связь ожирения с распространенностью и тяжестью ОА КС [9,20,21], ТБС [22][23][24][25], суставов кис-тей [26][27][28][29].…”

Section: ожирениеunclassified

Osteoarthritis and Obesity

Strebkova¹,

Алексеева²

2015

rsp

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В обзоре освещены проблемы влияния ожирения на развитие, прогрессирование, тяжесть остеоартроза (ОА), обсуждаются методы лечения ожирения при этом заболевании. Показано, что снижение массы тела у пациентов с ожирением и ОА ведет к уменьшению клинических проявлений. Несмотря на множество про-веденных исследований по влиянию немедикаментозной терапии ожирения у больных ОА (диета, физиче-ская активность), результаты остаются противоречивыми и требуют дальнейшего изучения. Ключевые слова: остеоартроз; ожирение. Для ссылки: Стребкова ЕА, Алексеева ЛИ. Остеоартроз и ожирение. Научно-практическая ревматология. 2015;53(5):542-52. OSTEOARTHRITIS AND OBESITYStrebkova E.A., Alekseeva L.I.The review highlights the impact of obesity on the development, progression, and severity of osteoarthritis (OA) and discusses treatments for obesity in this disease. Weight loss in obese patients with OA is shown to lead to a reduction in clinical manifestations. Despite a great deal of performed investigations of the impact of non-drug therapy for obesity (diet, physical activity), their results are contradictory and call for further investigation.

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“…4 More recently, OA has been linked to obesity. [5][6][7] Consequently OA is now considered as a major public health issue.…”

Section: Introductionmentioning

confidence: 99%

Featured Article: Deficiency of G-protein coupled receptor 40, a lipid-activated receptor, heightens in vitro- and in vivo-induced murine osteoarthritis

Monfoulet

Philippe

Mercier

et al. 2015

Exp Biol Med (Maywood)

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Osteoarthritis (OA) is an age-related degenerative joint disease. To date, its management is focused on symptoms (pain and inflammation). Studies suggest that fatty acids can reduce the expression of inflammatory and catalytic mediators, and improve in vivo joint function. Free fatty acid receptors (FFARs) such as G-protein coupled receptor 40 (GPR40) are proposed as attractive therapeutic targets to counteract inflammation and cartilage degradation observed in OA. This study aims to elucidate the involvement of GPR40 in OA. In this study, we used an in vitro model of OA, and surgically induced OA by ligament transection and partial meniscectomy in wild-type and GPR40 deficient mice. OA phenotype was investigated in vivo by histology and genes expression. We demonstrate that IL-1b-treated GPR40 À/À chondrocytes secret more inflammatory mediators (nitric oxide, interleukin-6, prostaglandin E2) and active catabolic enzymes (metalloproteinase-2, -9 [MMP-2, MMP-9]), and show decreased anabolism (glycoaminoglycan) compared to GPR40 þ/þ cells. In accordance with these results, we show that GPR40 À/À mice exhibit an aggravated OA-induced phenotype characterized by higher tidemark exposure, frequency of osteophyte formation and subchondral bone sclerosis. Altogether our results demonstrate that GPR40 deficiency leads to an extended OA phenotype, providing evidence that increasing GPR40 activity, by natural or synthetic ligands, could be a new strategy in the management of OA.

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Body mass index and susceptibility to knee osteoarthritis: A systematic review and meta-analysis

Cited by 285 publications

References 49 publications

Epidemiology of Posttraumatic Osteoarthritis

Epidemiology of Posttraumatic Osteoarthritis

Osteoarthritis and Obesity

Featured Article: Deficiency of G-protein coupled receptor 40, a lipid-activated receptor, heightens in vitro- and in vivo-induced murine osteoarthritis

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