Osteoarthritis and Obesity

Abstract

В обзоре освещены проблемы влияния ожирения на развитие, прогрессирование, тяжесть остеоартроза (ОА), обсуждаются методы лечения ожирения при этом заболевании. Показано, что снижение массы тела у пациентов с ожирением и ОА ведет к уменьшению клинических проявлений. Несмотря на множество про-веденных исследований по влиянию немедикаментозной терапии ожирения у больных ОА (диета, физиче-ская активность), результаты остаются противоречивыми и требуют дальнейшего изучения. Ключевые слова: остеоартроз; ожирение. Для ссылки: Стребкова ЕА, Алексеева ЛИ. Остеоартроз и ожирение. Научно-практическая ревматология. 2015;53(5):542-52. OSTEOARTHRITIS AND OBESITYStrebkova E.A., Alekseeva L.I.The review highlights the impact of obesity on the development, progression, and severity of osteoarthritis (OA) and discusses treatments for obesity in this disease. Weight loss in obese patients with OA is shown to lead to a reduction in clinical manifestations. Despite a great deal of performed investigations of the impact of non-drug therapy for obesity (diet, physical activity), their results are contradictory and call for further investigation.

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“…The current research in the sphere concentrates on several predictors among clinical and laboratory data (4C Deterioration and 4C Mortality Score). However, it should be noted that covariance between 4C Deterioration and 4C Mortality predictions did not differ as per sex or ethnicity and did not get weaker in younger age groups [34]. A research team from the University of Arizona, Harvard University and The National Center for Biotechnology Information (USA) has developed a mathematical model that makes it possible to estimate a probability of a cytokine storm in COVID-19 patients depending on how intensively cytokine production is stimulated by immune cells; the model relies on using multiple indicators.…”

“…Official statistical data over the period in 2010-2018 on all the RF regions were taken from the open sources and applied as initial data in sociohygienic determinants and LEB levels. In conformity with the Methodical guidelines MR 2.1.10.0269-21 'Identification of sociohygienic determinants and prediction of a potential growth in life expectancy at birth for the RF population, regional differentiation taken into account' 11 , the list of the examined indicators included 148 socio-hygienic determinants that were conditionally aggregated into 6 groups: sanitary-epidemiological wellbeing (53 indicators), socio-demographic indicators (34), lifestyle-related indicators (30), economic indicators (14), public healthcare (9 indicators), nature and climate (8 indicators).…”

Comorbidity of patients with noncommunicable diseases in general practice. Eurasian guidelines

“…МС утяжеляет клинические проявления остеоартроза. У больных с МС выявляются более высокие значения боли, функциональной недостаточности и утренней скованности в суставах [1521]. Снижение МТ, особенно при приеме препаратов, способствующих уменьшению веса, ведет к уменьшению клинических проявлений ОА коленных суставов: уменьшению боли и улучшению функционального состояния, улучшает КЖ пациентов.…”

NFAT gene polymorphism as a risk factor of knee osteoarthrosis

“…Fat tissue is known to produce adipokines that not only participate in metabolic processes but also make for chronic inflammatory reactions in the body. Adipokines and some other cytokines act together and these combined actions lead to cartilage tissue degradation [34]. T.N.…”