Body mass index and vaccine responses following influenza vaccination during pregnancy

Clarke, Michelle; Goodchild, Louise; Evans, S.; Giles, Lynne; Sullivan, Sheena G.; Barr, Ian G.; Lambert, Stephen B.; Marshall, Helen

doi:10.1016/j.vaccine.2021.06.065

Cited by 5 publications

(2 citation statements)

References 28 publications

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“…There are an increasing number of recent studies assessing the association between obesity and influenza vaccine responses in adults with conflicting findings [ 25 , 26 , 27 ]. In contrast, there are only a few small studies describing influenza vaccine responses in obese children and adolescents [ 17 , 18 , 19 ], and none of these studies characterizes the immune responses through to 6-months post-vaccination.…”

Section: Discussionmentioning

confidence: 99%

A Prospective Study Investigating the Impact of Obesity on the Immune Response to the Quadrivalent Influenza Vaccine in Children and Adolescents

et al. 2022

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Obesity can increase the severity of influenza infection. Data are limited regarding immune responses to influenza vaccination in obese children. We aimed to investigate the impact of obesity on quadrivalent influenza vaccine responses in children. Children with obesity (body mass index (BMI) ≥ 95th percentile for age and gender) and children without obesity (BMI < 95th percentile) were enrolled in the study. Blood samples were collected before, 1, and 6 months after influenza vaccination, to measure antibody responses by haemagglutination inhibition (HI) assay. Vaccine immunogenicity outcomes were compared between children with and without obesity. Forty-four children (mean age 13.3 ± 2.1 years, 18 males and 14 with obesity) completed the 6-month study. More than 90% of the participants with and without obesity had seroprotective antibody titres (HI ≥ 40) at both 1 and 6 months following vaccination for each of the four influenza strains (A/H3N2, A/H1N1, B/(Victoria) and B/(Yamagata)). Influenza-specific geometric mean titres at baseline, 1, and 6 months post-vaccination were similar between children with and without obesity for all influenza vaccine strains. Children with and without obesity have robust, sustained antibody responses over 6 months to the quadrivalent influenza vaccine.

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Section: Discussionmentioning

confidence: 99%

A Prospective Study Investigating the Impact of Obesity on the Immune Response to the Quadrivalent Influenza Vaccine in Children and Adolescents

et al. 2022

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“…As for other vaccines, there are less clear-cut positions. For example, opinions on influenza vaccine response are both that BMI influences it [ 41 , 42 , 43 , 44 ] and that it does not [ 45 , 46 ]. The same applies for the hepatitis A vaccine, with studies both favoring [ 47 , 48 ] and opposing [ 49 ] a relationship between BMI and immune response to the vaccine.…”

Section: Discussionmentioning

confidence: 99%

Body Mass Index and Antibody Persistence after Measles, Mumps, Rubella and Hepatitis B Vaccinations

Fonzo

Nicolli²,

Maso³

et al. 2022

Vaccines

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Overweight and obesity may cause a reduced response to vaccination. The purpose of the present research was to study the relationship between current body mass index (BMI) and antibody persistence after vaccination against measles, mumps, and rubella (MMR) and hepatitis B virus (HBV) given during childhood, as per the current vaccination schedule. The study was conducted on 2185 students at the School of Medicine, University of Padua, Italy. The mean age of the participants was 20.3 years. After adjusting for sex, age at first dose of vaccine administered, age at last dose, and age at study enrollment, no significant association was found between lack of serologic protection and BMI for either the HBV vaccine or each component of the MMR vaccine. For the first time, the absence of this relationship was demonstrated for the MMR vaccine. Given the evidence currently available, further research on BMI and vaccines in general remains desirable.

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Obesity in adolescents does not influence early immune responses to influenza vaccination

Kristinsdóttir

Haraldsson

Brynjólfsson

et al. 2023

Infectious Diseases

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Body mass index and vaccine responses following influenza vaccination during pregnancy

Cited by 5 publications

References 28 publications

A Prospective Study Investigating the Impact of Obesity on the Immune Response to the Quadrivalent Influenza Vaccine in Children and Adolescents

A Prospective Study Investigating the Impact of Obesity on the Immune Response to the Quadrivalent Influenza Vaccine in Children and Adolescents

Body Mass Index and Antibody Persistence after Measles, Mumps, Rubella and Hepatitis B Vaccinations

Obesity in adolescents does not influence early immune responses to influenza vaccination

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