Body mass index: impact on IVF success appears age-related

Sneed, Megan L.; Uhler, M.L.; Grotjan, H. Edward; Rapisarda, J.; Lederer, K.; Beltsos, Angeline

doi:10.1093/humrep/den188

Cited by 127 publications

(104 citation statements)

References 20 publications

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“…Additionally, we did not observe an association between female BMI and ART success. However, as shown by Sneed et al, it is likely that the impact of BMI on ART is only manifested at younger female ages, whereas after age 36 the effect of chronological aging appears to dominate any BMI effect [30]. We did not have sufficient power to consider the relationship between female BMI and ART outcome in detail; however, among women younger than 32, there was a suggestion for lower female BMI in successful couples.…”

Section: Discussionmentioning

confidence: 79%

“…Although studies on the effects of obesity on ART have produced conflicting results, a recent metaanalysis of 21 studies concluded that women with BMI greater than 25 kg/m 2 had a significantly lower chance of clinical pregnancy as compared with normal weight women [29]. A potential breakthrough in understanding the precise relationship between obesity and ART success came from a recent study showing that at younger ages high female BMI had a pronounced negative influence on fertility, but after age 36, body mass had a minimal impact on fertility [30]. In contradistinction to the avalanche of data on female obesity and ART, knowledge on the influence of male body mass on IVF success is scarce.…”

Section: Discussionmentioning

confidence: 99%

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Overweight Men: clinical pregnancy after ART is decreased in IVF but not in ICSI cycles

Keltz

Zapantis

Jindal

et al. 2010

J Assist Reprod Genet

100

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Purpose To evaluate if elevated male body mass influences success after assisted reproductive technologies Methods Retrospective study of 290 cycles. Results Male body mass index greater than 25.0 kg/m 2 was associated with significantly lower clinical pregnancy (53.2% vs. 33.6%). Multivariable logistic regression indicated that the likelihood of clinical pregnancy was decreased if the male partner was overweight after in vitro fertilization but not after intracytoplasmic sperm injection (odds ratios: 0.21 [0.07-0.69] vs. 0.75 [0.38-1.49], respectively) after adjustment for number of embryos transferred, sperm concentration, female age and body mass. Conclusion In this cohort, overweight status of the male partner was independently associated with decreased likelihood of clinical pregnancy after in vitro fertilization but not after intracytoplasmic sperm injection. A detrimental impact of higher male body mass was observed after adjusting for sperm concentration, suggesting that intracytoplasmic sperm injection may overcome some obesity related impairment of sperm-egg interaction.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Overweight Men: clinical pregnancy after ART is decreased in IVF but not in ICSI cycles

Keltz

Zapantis

Jindal

et al. 2010

J Assist Reprod Genet

100

View full text Add to dashboard Cite

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“…In Erel et al, 2009 a literature review was performed difference between patients with different BMI. Zander -Fox et al, 2012, Singh et al, 2012, Vilarino et al, 2011, Bellver et al, 2010and Sathya et al, 2010 have not Sneed et al, 2008, showed that the interaction between however, BMI alone had no apparent effect. This had a greater impact on patients under 36 years, because in older women age became the most important factor.…”

Section: Number Of Oocytes Retrievedmentioning

confidence: 95%

“…One was the study of Veleva et al (2008) , which showed that the BMI graph curve that represents how BMI affects the miscarriage rate is U-shaped, meaning that patients of low weight also has their increased risk, independent of patient age ( Figure 3 ). Moreover, the revision of Rittenberg et al, 2011 revealed increased miscarriage rate in 14 studies (RR 1.36, 95 % CI 1.13 to 1.64, p et al, 2010, despite the rate being increased, this increase was not significant, as in Vilarino et al, 2011, Zhang et al, 2010and Sathya et al .,2010. Sneed et al, 2008 showed that miscarriage rate is not directly affected by BMI, but by the interaction between BMI and age, with age the main determining factor.…”

Section: Miscarriage Ratementioning

confidence: 96%

“…The LBR in patients within the normal range was 31.3 % and 23.7 % in obese patients (p of BMI increased above the normal unit is 0.981 (95 % CI 0.967 to 0.995) for the LBR (p Zhang et al, 2010 showed that there was no difference in this rate between patients with normal weight, overweight and obese ( 26.2 % vs 23.7 % vs 26 %, respectively) with p value greater than 0.05. In Sneed et al, 2008 of the woman and IVF results. The effect of BMI was strongly related to patient's age and can't be regarded as an isolated factor.…”

Section: Live Birth Ratementioning

confidence: 99%

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Obese women and in vitro fertilization: results

Koatz¹,

Souza²

2013

JBRA Assisted Reproduction

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Objective: To evaluate the effect of female obesity on the results of In Vitro Fertilization (IVF) in six parameters: dose of gonadotropins required, number of oocytes retrieved and fertilization, pregnancy, miscarriage and live births rates. method: Literature search in PUBMED articles in English between 2008 and 2013 using the following keywords: female, obesity and In Vitro Fertilization. 15 articles were selected for this work. Results: From the total only two articles showed that female obesity does not alter the results of IVF. The remaining 13 came to the conclusion that obesity has a negative effect on some of the parameters evaluated. However, there was no consensus about its effect. Conclusion: Further studies are needed to clarify the real role of obesity in female patients undergoing IVF, but the weight loss prior to treatment should always be encouraged. keywords: Female, Obesity and In Vitro Fertilization. RESUmOObjetivo: Avaliar o efeito da obesidade feminina nos resultados da fertilização in vitro (FIV) em seis parâmetros: recuperados e fertilização, gravidez, aborto e taxas de nascidos vivos. método: Inglês, entre 2008 e 2013, utilizando as seguintes palavraschave: mulher, obesidade e fertilização in vitro. 15 artigos foram selecionados para este trabalho. Resultados: Do total apenas dois artigos mostraram que a obesidade feminina não altera os resultados de fertilização in vitro. Os restantes 13 chegaram à conclusão de que a obesidade tem um efeito negativo sobre alguns dos parâmetros avaliados. no entanto, não houve consenso sobre o seu efeito. Conclusão: Mais estudos são necessários para esclarecer o real papel da obesidade em pacientes do sexo feminino submetidas a fertilização in vitro, mas a perda de peso antes do tratamento deve ser sempre incentivada. Palavras-chave: feminino, obesidade e fertilização in vitro.

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Association of overweight and obesity with cumulative live birth rates according to women's age: A cohort study of 26 567 treatment cycles

Cai,

Xue,

Liu

et al. 2023

Intl J Gynecology & Obste

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ObjectiveTo evaluate the effect of age on the association between maternal body mass index (BMI) and cumulative live birth rates (CLBRs) following in vitro fertilization treatment.MethodWe retrospectively analyzed the data of 26 567 women undergoing in vitro fertilization/intracytoplasmic sperm injection from 2016 to 2019. We conducted multivariate regression analysis of the association between CLBRs and maternal BMI and age category.ResultsA total of 16 626 (62.58%) patients achieved a live birth. Women with obesity had significantly decreased CLBRs compared with women who had normal weight (odds ratio [OR] 0.73 [95% confidence interval (CI), 0.66–0.80]). The significant interaction between age and BMI suggested that the impact of BMI on CLBRs was moderated by women's age (P interaction <0.001). The association between obesity and CLBRs was inverse among women aged <30 years (OR, 0.63 [95% CI, 0.54–0.73]), 30 to 34 years (OR, 0.79 [95% CI, 0.67–0.93]), and 35 to 37 years (OR, 0.71 [95% CI, 0.52–0.98]); however, decreases in CLBRs with obesity were not observed in women aged 38 to 40 years (OR, 1.17 [95% CI, 0.70–1.94]) and ≥ 41 years (OR, 1.25 [95% CI, 0.53–2.96]).ConclusionMaternal obesity was significantly associated with a lower likelihood of having a live birth, but the risk differed according to women's age. A higher BMI might have a less‐pronounced detrimental effect with increasing age.

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Body mass index: impact on IVF success appears age-related

Abstract: In younger patients undergoing IVF, BMI has a significant negative impact on fertility that diminishes as patients reach their mid thirties. After Age 36, BMI has a minimal impact on fertility.

Cited by 127 publications

References 20 publications

Overweight Men: clinical pregnancy after ART is decreased in IVF but not in ICSI cycles

Overweight Men: clinical pregnancy after ART is decreased in IVF but not in ICSI cycles

Obese women and in vitro fertilization: results

Association of overweight and obesity with cumulative live birth rates according to women's age: A cohort study of 26 567 treatment cycles

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