Overweight Men: clinical pregnancy after ART is decreased in IVF but not in ICSI cycles

Abstract

Purpose To evaluate if elevated male body mass influences success after assisted reproductive technologies Methods Retrospective study of 290 cycles. Results Male body mass index greater than 25.0 kg/m 2 was associated with significantly lower clinical pregnancy (53.2% vs. 33.6%). Multivariable logistic regression indicated that the likelihood of clinical pregnancy was decreased if the male partner was overweight after in vitro fertilization but not after intracytoplasmic sperm injection (odds ratios: 0.21 [0.07-0.69] vs. 0.75 [0.38-1.49], respectively) after adjustment for number of embryos transferred, sperm concentration, female age and body mass. Conclusion In this cohort, overweight status of the male partner was independently associated with decreased likelihood of clinical pregnancy after in vitro fertilization but not after intracytoplasmic sperm injection. A detrimental impact of higher male body mass was observed after adjusting for sperm concentration, suggesting that intracytoplasmic sperm injection may overcome some obesity related impairment of sperm-egg interaction.

Nutritional modifications in male infertility: a systematic review covering 2 decades

“…[27][28][29][30] Recent evidence from both animal and human studies indicates that male obesity and high-fat diets result in impaired reproductivity, affecting the molecular and physical structure of sperm as well as the health of the developing fetus and subsequent offspring. 27,[31][32][33][34][35][36][37][38][39] In a recent animal study, Rato et al 39 reported that the testicular physiology is sensitive to alterations of whole-body metabolism and that the testicular metabolism can be disturbed by high-energy diets. Disruption of testicular metabolism is associated with decreased sperm quality.…”

Female offspring sired by diet induced obese male mice display impaired blastocyst development with molecular alterations to their ovaries, oocytes and cumulus cells

“…More than one-third of men of reproductive age in the United States are classified as obese [1]. Paternal obesity not only impairs male fertility by impacting sperm count, motility and chromatin integrity [2][3][4][5][6][7] but also reduces subsequent embryo development, implantation rates, pregnancy success and live birth rates [8][9][10][11][12]. Interestingly metabolic syndrome, which includes obesity, in fathers is associated with polycystic ovary syndrome in daughters [13].…”

Diet and exercise in an obese mouse fed a high-fat diet improve metabolic health and reverse perturbed sperm function

“…Consequently, the rates of male obesity in reproductive age men has nearly tripled since the 1970s (33). Recent studies in both humans and other species shows that male obesity impairs male reproductive potential, affecting both the molecular and physical structure of sperm (1,10,16,20,21,34,35,38,45,47,50,63,75,79) and the health of the developing fetus and subsequent offspring (9,24,42,55,59). …”

“…There is a negative impact of male obesity on standard semen parameters, including motility, count, and hormone abundance, such as testosterone and inhibin B (1,5,16,18,21,22,32,35,37,45,47,52,62,69,85). Further studies have reported reduced pregnancy success and live birth outcomes after IVF treatment in overweight and obese men (9,42).…”