Body mass index predictive of sputum culture conversion among MDR-TB patients in Indonesia

Putri, Fauziah Asnely; Burhan, Erlina; Nawas, Arifin; Soepandi, Priyanti Zuswayudha; Sutoyo, Dianiati Kusumo; Agustin, Heidy; Isbaniah, Fathiyah; Dowdy, David W.

doi:10.5588/ijtld.13.0602

Cited by 66 publications

(63 citation statements)

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“…The double effect of smoking behavior, Diabetes mellitus and the nutritional deficiencies as risk factors for TB and delayed conversion have been described (Bhargava et al, 2013;Putri et al, 2014;Agrawal, 2017;Nakamura et al, 2014;Shariff and Safian, 2015;Guanche et al, 2016;Long and Schwartzman, 2013;Cegielski et al, 2012;Magee et al, 2014;Tachouti et al, 2011). The low frequency of active smoker, the mandatory admission for infectious patients and the compliance with the non-smoking policy in healthcare facilities could be related to our results.…”

Section: Discussionsupporting

confidence: 70%

“…The conversion time has been related with multiple factors including nutritional factors such as anemia, magnesium level, and body mass index (Bhargava et al, 2013;Putri et al, 2014;Agrawal, 2017), history of diabetes mellitus and poor metabolic control (Mi et al, 2013;Nakamura et al, 2014;Sharif, 2015), bacillary load in the diagnosis (D'Souza et al, 2018;Kanda et al, 2015;Gunda, 2017), diagnosis delay and radiological lesions suggestive of extensive damage or cavitation (Mi et al, 2013;Nakamura et al, 2014;Unsematham and Kateruttanakul, 2013;Visser et al, 2012) and drug resistance (Kim et al, 2016;Holtz et al, 2006;Kurbatova et al, 2012). A previously published paper identifies the bacillary load in the diagnosis as the main factor related with sputum conversion in patients attended to in a community hospital in Qatar, but the study is limited by the number of patients studied (64 patients) (Guanche et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Factors associated with sputum conversion in a multinational population of tuberculosis patients

Garcell¹,

Arias²,

García³

et al. 2018

J. Public Health Epidemiol.

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Section: Discussionsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Factors associated with sputum conversion in a multinational population of tuberculosis patients

Garcell¹,

Arias²,

García³

et al. 2018

J. Public Health Epidemiol.

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“…XDR-TB can be primarily transmitted from person to person or secondary to the development through high bacillary load, inadequate treatment (poor compliance, iatrogenic, drug stock outs, programatic weakness), low body mass index, or previous failures [34][35][36][37][38]. Prevention of the development of drug-resistant TB is essential given the recent worldwide increase in incidence.…”

Section: Prevention Of Xdr-tb During Mdr-tb Treatmentmentioning

confidence: 99%

Individualizing management of extensively drug-resistant tuberculosis: diagnostics, treatment, and biomarkers

Alffenaar

Akkerman

Anthony

et al. 2016

Expert Review of Anti-infective Therapy

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Introduction: Success rates for treatment of extensively drug resistant tuberculosis (XDR-TB) are low due to limited treatment options, delayed diagnosis and inadequate health care infrastructure. Areas covered: This review analyses existing programmes of prevention, diagnosis and treatment of XDR-TB. Improved diagnostic procedures and rapid molecular tests help to select appropriate drugs and dosages. Drugs dosages can be further tailored to the specific conditions of the patient based on quantitative susceptibility testing of the M. tuberculosis isolate and use of therapeutic drug monitoring. Pharmacovigilance is important for preserving activity of the novel drugs bedaquiline and delamanid. Furthermore, biomarkers of treatment response must be developed and validated to guide therapeutic decisions. Expert commentary: Given the currently poor treatment outcomes and the association of XDR-TB with HIV in endemic regions, a more patient oriented approach regarding diagnostics, drug selection and tailoring and treatment evaluation will improve treatment outcome. The different areas of expertise should be covered by a multidisciplinary team and may involve the transition of patients from hospitalized to home or community-based treatment.

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“…It is supported by a study by Hicks et al (2014) which revealed one one the factors influence MDR TB incidences and even continued to death namely poor nutritional status on TB patients. Putri et al (2014) mentioned that poor nutritional status caused treatment of the patients became less effective and prevent the occurrence of sputum culture conversion in the initial phase of MDR TB treatment. It is elaborated by Park et al (2016) and Tang et al (2013) that poor nutritional status is often discovered on patients who endure resistance to TB medication because of the decreasing body immune that disturb immune system toward mycobacteruim tuberculosis.…”

Section: The Association Between Nutri-mentioning

confidence: 99%

Health Belief Model and PRECEDE PROCEED on the Risk Factors of Multidrug Resistant Tuberculosis in Surakarta, Central Java

Vera

Rahardjo

Murti

2017

J EPIDEMIOL PUBLIC HEALTH

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Background: Tuberculosis (TB) is one of the lethal infectious diseases in the world. One of the current biggest challenges of Tuberculosis control is the widespread emergence of Multidrug Resistant Tuberculosis (MDR-TB). There are several potential risk factors of MDR-TB that can be explained by Health Belief Model and PRECEDE PROCEED model framework. This study aimed to analyzed factors associated with MDR-TB using Health Belief Model and PRECEDE PROCEED. Subjects and Method:This was an analytic observational study with case control design. The study was conducted at Dr. Moewardi Hospital and BBKPM, Surakarta, from September to November 2017. The study subjects were selected using fixed disease sampling, consisting of 76 MDR-TB patients and 228 TB patients. The dependent variable was MDR-TB. The independent variables were educational level, self-efficacy, drug-taking adherence, smoking, nutritional status, perceived of susceptibility, perceived barrier, perceived severity, perceived benefit, and drug-taking supervisor. The data were collected using questionnaire and analyzed by path analysis. Results: The risk of MDR-TB was increased by lack of drug-taking adherence (b= -1.69; 95% CI= -2.28 to -1.09; p <0.001), poor nutritional status (b= 1.32; 95% CI= 0.72 to 1.92; p<0.001), and smoking (b= 1.32; 95% CI= 0.72 to 1.92; p <0.001). Drug-taking adherence was increased by perceived susceptibility (b= 0.91; 95% CI= 0.18 to 1.63; p=0.015), perceived severity (b= 1.01; 95% CI= 0.28 to 1.74; p=0.007), perceived benefit (b= 1.69; 95% CI= 0.97 to 2.41; p<0.001), drugtaking advisor (b= 2.16; 95% CI= 1.44 to 2.88; p<0.001), self efficacy (b= 1.58; 95% CI= 0.86 to 2.31; p<0.001), and low perceived barrier (b= -1.10; 95% CI= -1.82 to -0.38; p=0.003). Conclusion:The risk of MDR-TB is increased by the lack of drug-taking adherence, poor nutritional status, and smoking.

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Body mass index predictive of sputum culture conversion among MDR-TB patients in Indonesia

Abstract: Severe underweight was associated with longer time to initial sputum culture conversion among MDR-TB patients.

Cited by 66 publications

References 0 publications

Factors associated with sputum conversion in a multinational population of tuberculosis patients

Factors associated with sputum conversion in a multinational population of tuberculosis patients

Individualizing management of extensively drug-resistant tuberculosis: diagnostics, treatment, and biomarkers

Health Belief Model and PRECEDE PROCEED on the Risk Factors of Multidrug Resistant Tuberculosis in Surakarta, Central Java

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