Body Mass Index Trajectories in Early Life Is Predictive of Cardiometabolic Risk

Yuan, Yue; Chu, Chao; Zheng, Wenfang; Ma, Qiang; Hu, Jiawen; Wang, Yan; Yu, Yan; Liao, Yue‐Yuan

doi:10.1016/j.jpeds.2019.12.060

Cited by 40 publications

(71 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our ndings indicated that women in both overweight and obese trajectories were more likely to have HTN, DM, and dyslipidemia, suggesting the importance of early intervention. Previous studies have illustrated that an elevated BMI in women contributes to a high risk for DM, HTN, and high-risk HDL cholesterol, consistent with our results (54)(55)(56)(57). In contrast, another study indicated that a rising trend of BMI was not associated with high blood pressure (58).…”

Section: Discussionsupporting

confidence: 92%

Predictive Value of Women’s Weight Trajectories in Determining Familial Cardiovascular Disorders: A Family Based Longitudinal Study

Naseri

Amiri

Zareie-Shabkhaneh

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Considering dynamic nature of body mass index (BMI) in women, is crucial to determine cardiovascular risks in both individual and familial levels. This study aimed to investigate the life-course trajectory pattern of women's BMI and its association with cardiovascular risk factors in them and their family members. Methods: Based on the Tehran Lipid and Glucose Study (TLGS), a total of 1356 mothers with 2976 children (51.8 % girls) aged ≤ 18 years at baseline were recruited in the current analysis and followed up for an average period of 15 years. Cardiovascular risk factors, including hypertension (HTN), dyslipidemia, diabetes mellitus (DM), and obesity were considered as outcome variables. Latent growth curve modelling (LGCM) was applied to determine women's BMI trajectories; then, logistic regression was used to investigate the associations between trajectory patterns of women and cardiovascular risk factors among whole family members.Results: Women were classified into three trajectory groups labeled as normal, overweight, and obese. Compared to women's in the normal trajectory group, those in the overweight and obesity trajectory groups had higher odds ratios for HTN, DM, and dyslipidemia (p < 0.05). In the final model, men with obese spouses showed a higher rate of HTN 1.54 (95% CI: 1.05-2.25) and DM 1.55; (95% CI: 1.00–2.44). The odds of men's obesity were higher in their obese spouses compared to normal weight ones, and the odds ratios were (OR=1.70; 95%CI: 1.10-2.62). Offspring of obese and overweight mothers were more likely to be obese than those whose mothers were normal weight. The odds ratios were (OR=2.39; 95%CI: 1.67-3.44) and (OR=4.81; 95%CI: 3.16-7.34) respectively. The corresponding value for dyslipidemia in offspring with obese mothers were 1.39 (95% CI: 1.00-1.94). Conclusions: Our results showed that women's weight status over time, play a critical role in determining cardiovascular risk, not only in them but also in their family members. The current results emphasized paying more attention to women with excessive weight to promote familial cardiovascular health in the communities.

show abstract

Section: Discussionsupporting

confidence: 92%

Predictive Value of Women’s Weight Trajectories in Determining Familial Cardiovascular Disorders: A Family Based Longitudinal Study

Naseri

Amiri

Zareie-Shabkhaneh

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…[10][11][12][13][14] Yuan et al once reported three different BMI trajectories in early life that are correlated with cardiometabolic risk. 15 Nevertheless, a few studies have confirmed BMI trajectory classes and their relationship with the incidence of hypertension from mid-life to elderly adulthood. In this study, we assumed that participants in distinct BMI trajectories were at a different risk of incident hypertension during their mid-life to elderly adulthood, and from…”

Section: Introductionmentioning

confidence: 99%

Trajectories of mid-life to elderly adulthood BMI and incident hypertension: the China Health and Nutrition Survey

Zeng

Sun

2021

BMJ Open

View full text Add to dashboard Cite

ObjectivesThis study is designed to identify different body mass index (BMI) trajectories of individuals aged 40–70 years and test the effect of distinct BMI trajectories on incident hypertension.DesignThe accelerated longitudinal design was used for this study.MethodsThe study drew data from the third to ninth China Health and Nutrition Surveys (CHNS), and 4697 participants were included between 1991 and 2015. As analysed, three distinct individual BMI trajectories were identified by the latent class growth mixed model (LCGMM). Then, BMI values and BMI slopes were worked out through calculation with LCGMM trajectory parameters and their primary derivatives, respectively. Later, Cox proportional hazard models were applied to examine BMI values and slopes, and find out the relationship between the said predicted data and incident hypertension for different classes.ResultsThree different trajectory classes were identified, that is, low-stable class (n=3711), sharp-increasing class (n=282) and high-stable class (n=704). Compared with the low-stable class, the adjusted HRs (95% CI) were 1.321 (1.119 to 1.559) and 1.504 (1.322 to 1.711) for the sharp-increasing class and the high-stable class, respectively. The HR (95% CI) for BMI values rose from 1.081 (1.030 to 1.135) to 1.221 (1.171 to 1.273) while the HR (95% CI) for BMI slopes dropped from 1.154 (1.100 to 1.211) to 0.983 (0.943 to 1.025). That is, the HR for BMI slopes were higher than that for BMI values for the class aged 40–47 years.ConclusionThese findings suggest that the calibrated BMI trajectories for the period from mid-life to elderly adulthood have a significant effect on the risk of incident hypertension. The period from age 40 to 47 years is critical and has positive implications for the early prevention of hypertension.

show abstract

“…According to 2018 Chinese guidelines for the management of hypertension, individuals with early stages of arterial stiffness were defined as those with a nonatherosclerotic CIMT ≥ 0.9 mm [ 12 ]. In the current study, we defined arterial stiffness as baPWV ≥ 1400 cm/s and/or CIMT ≥ 0.9 mm as previously reported [ 25 , 38 ].…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, high baPWV was defined as baPWV ≥ 1,400 cm/s [30,36]. The CIMT, defined as the distance the distance from the intima-luminal interface to the media-adventitial interface, was measured as described elsewhere [25,38]. CIMT was bilaterally visualized and measured at the plaque-free area of the common carotid arteries (10-20mm proximal to the tip of the flow divider).…”

Section: Laboratorymentioning

confidence: 99%

Association of Uric Acid in Serum and Urine with Arterial Stiffness: Hanzhong Adolescent Hypertension Study

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background. Hyperuricemia has long been associated with increased cardiovascular risk, and arterial stiffness is proposed as a mediator. The present study is aimed at examining the associations of uric acid (UA) in blood and urine with arterial stiffness in a Chinese cohort. Methods. A total of 2296 participants (mean age: 43.0 years) from our previously established cohort of Hanzhong Adolescent Hypertension Study were included. The participants were classified as subjects with or without arterial stiffness, which was defined as brachial-ankle pulse wave velocity baPWV≥1400 cm/s and/or carotid intima-media thickness CIMT≥0.9 mm. Multivariate regression analyses were used to examine the relationship between serum and urinary UA and the risk of arterial stiffness after adjusting for age, gender, systolic blood pressure, fasting glucose, BMI, heart rate, total cholesterol, and triglycerides. Results. baPWV was positively correlated with urinary uric acid/creatinine ratio (uUA/Cre) (β=0.061, P<0.001), while CIMT was correlated with uUA/Cre (β=0.085, P<0.001) and fractional excretion of uric acid (FEUA) (β=0.044, P=0.033) in all subjects. In addition, uUA/Cre was significantly associated with the risk of high baPWV [1.032 (1.019-1.045)] and arterial stiffness [1.028 (1.016-1.040)]. Conclusion. Our study showed that urinary UA excretion was significantly associated with the risk of arterial stiffness in Chinese adults. These findings suggest that UA, especially urinary UA, may be used as a simple, noninvasive marker for early detection of arterial stiffness in otherwise healthy subjects.

show abstract

Body Mass Index Trajectories in Early Life Is Predictive of Cardiometabolic Risk

Cited by 40 publications

References 30 publications

Predictive Value of Women’s Weight Trajectories in Determining Familial Cardiovascular Disorders: A Family Based Longitudinal Study

Predictive Value of Women’s Weight Trajectories in Determining Familial Cardiovascular Disorders: A Family Based Longitudinal Study

Trajectories of mid-life to elderly adulthood BMI and incident hypertension: the China Health and Nutrition Survey

Association of Uric Acid in Serum and Urine with Arterial Stiffness: Hanzhong Adolescent Hypertension Study

Contact Info

Product

Resources

About