Body mass is the primary determinant of midfemoral bone acquisition during adolescent growth

Moro, M.J.; Meulen, Marjolein C. H. van der; Kiratli, B. Jenny; Marcus, Robert; Bachrach, Laura K.; Carter, D.R.

doi:10.1016/s8756-3282(96)00263-3

Cited by 87 publications

(58 citation statements)

References 38 publications

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“…11 In this study, the normalization of the data by body mass and height resulted in the loss of significant negative correlation of these parameters with age. Consistent with Moro et al's 26 and van der Meulen et al's 27 findings on the effect of body size on femoral cross-sectional properties of adolescents and young adults, the loss of correlation after normalization for body size found here indicates that body mass is an important determinant of bone size. Therefore, only the results normalized by body size should be considered.…”

Section: Discussionsupporting

confidence: 92%

Interactions between microstructural and geometrical adaptation in human cortical bone

Ural

Vashishth

2006

J. Orthop. Res.

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With aging and in disease, the changes in bone microstructure and geometry influence the mechanical properties of cortical bone, however, the level of interaction between the two is not known. Here, we investigate the interaction between the changes in microstructural and geometrical properties of the aging male tibia in proximal and distal middiaphysis. The microstructural measurements include variables related to the size and density of osteons and intracortical porosity. The macroscopic geometrical properties include variables related to bone surfaces (periosteal and endosteal) and cross section (area, moment of inertia). Site-specific correlations were found between the microstructural and geometrical properties along the bone length and at different bone surfaces. In contrast to the proximal middiaphysis of male tibia, where no correlation existed, significant (p < 0.05) correlations were found in the distal middiaphysis of tibia. The changes in parameters partially related to bone formation in the cortex, including the osteonal area, showed positive correlations with an increase in the periosteal diameter. Similarly, parameters related to bone resorption and/or failed formation in the cortex, including porosity and pore size, showed significant correlations with cortical thinning. These findings support the concept that, with aging, anabolic and catabolic responses in the human tibia at microstructural and macrostructural levels are spatially related and site specific. ß

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Section: Discussionsupporting

confidence: 92%

Interactions between microstructural and geometrical adaptation in human cortical bone

Ural

Vashishth

2006

J. Orthop. Res.

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“…Multiple regression analysis revealed that the greater gains in femoral cross-sectional growth of boys were related to simultaneous greater gains in height and body weight. The results of the current study corroborate previous studies indicating that, although femoral crosssectional bone acquisition is primarily driven by mechan- ical load related to increasing body mass, vertebral crosssectional growth is not only associated with increasing body mass, but is also strongly influenced by gender (34,35). Nutritional analyses revealed that dietary calcium intake did not correlate with baseline values or changes in any of the skeletal phenotypes in girls, in boys, or when all children were considered together.…”

Section: Discussionsupporting

confidence: 89%

Early Identification of Children Predisposed to Low Peak Bone Mass and Osteoporosis Later in Life¹

Loro¹,

Sayre

Roe

et al. 2000

The Journal of Clinical Endocrinology & Metabolism

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The amount of bone that is gained during adolescence is the main contributor to peak bone mass, which, in turn, is a major determinant of osteoporosis and fracture risk in the elderly. We examined whether computed tomography measurements for the density and the volume of bone in the axial and the appendicular skeletons could be tracked through puberty in 40 healthy white children (20 girls and 20 boys). Longitudinal measurements of the cross-sectional area and cancellous bone density of the vertebral bodies and the cross-sectional and cortical bone areas of the femurs at the beginning of puberty accounted for 62-92% of the variations seen at sexual maturity; on average, 3 yr later. When baseline values for these bone traits were divided into quartiles, a linear relation across Tanner stages of sexual development was observed for each quartile in both girls and boys. The regression lines differed among quartiles for each trait, paralleled each other, and did not overlap. Thus, we are now in a position to identify those children who are genetically prone to develop low values for peak bone mass and toward whom osteoporosis prevention trials should be geared. (J Clin Endocrinol Metab 85: 3908 -3918, 2000) R ECENT DATA suggest that the genetic susceptibility to osteoporosis may be detectable in early childhood (1). Studies have shown a familial resemblance for bone mineral mass between prepubertal girls and their mothers and that genes linked to osteoporosis and/or fractures in adulthood are associated with low bone mass in prepubertal children (1-3). In addition, peak bone mass, a major determinant of the risk for osteoporosis and fractures in the elderly, is virtually achieved at the end of sexual development in the lumbar spine and the femur (4 -6). By the age of 16 yr, most children have completed sexual maturity, and studies have shown that bone mass values in girls by this age are equal or greater to that of their premenopausal mothers (7,8).Puberty is the time of life when the greatest acquisition of bone occurs (6, 9). Regardless of gender, bone mass more than doubles during puberty (10). In this study, we used computed tomography (CT) to longitudinally measure the densities of cancellous and cortical bone and the crosssectional dimensions of bone in the axial and appendicular skeletons of children at each Tanner stage of sexual development from early puberty to sexual maturity. Our aims were to examine whether measures for quantitative phenotypic traits, which contribute to bone mass and bone strength, at sexual maturity can be predicted from values in early puberty and to assess the constancy of a child's expected measures relative to population percentiles. This knowledge may aid in the early identification of those children who are at risk for osteoporosis and fragility fractures later in life. Subjects and Methods Study populationThe study subjects were healthy white children who were recruited from schools of Los Angeles County. The investigational protocol was approved by the institutional...

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“…Moreover, we suspect the scaling laws that apply to adolescent human femurs would be different as well. Without data on the scaling laws of dog or adolescent human femurs, we chose to substitute dog femurs whose BMC, and Z ranges were consistent with the in vivo measurements of adolescent human femurs reported by Moro et al (1996) and van der .…”

Section: Discussionmentioning

confidence: 99%

DXA-derived section modulus and bone mineral content predict long-bone torsional strength

Sarin

Polefka

Beaupré

et al. 1999

Acta Orthopaedica Scandinavica

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Body mass is the primary determinant of midfemoral bone acquisition during adolescent growth

Cited by 87 publications

References 38 publications

Interactions between microstructural and geometrical adaptation in human cortical bone

Interactions between microstructural and geometrical adaptation in human cortical bone

Early Identification of Children Predisposed to Low Peak Bone Mass and Osteoporosis Later in Life¹

DXA-derived section modulus and bone mineral content predict long-bone torsional strength

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Body mass is the primary determinant of midfemoral bone acquisition during adolescent growth

Cited by 87 publications

References 38 publications

Interactions between microstructural and geometrical adaptation in human cortical bone

Interactions between microstructural and geometrical adaptation in human cortical bone

Early Identification of Children Predisposed to Low Peak Bone Mass and Osteoporosis Later in Life1

DXA-derived section modulus and bone mineral content predict long-bone torsional strength

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Product

Resources

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Early Identification of Children Predisposed to Low Peak Bone Mass and Osteoporosis Later in Life¹