Body Size and Renal Cell Cancer Incidence in a Large US Cohort Study

Adams, Kenneth; Leitzmann, Michael F.; Albanês, Demetrius; Kipnis, Victor; Moore, Stephen; Schatzkin, Arthur; Chow, Wong Ho

doi:10.1093/aje/kwn122

Cited by 162 publications

(125 citation statements)

References 41 publications

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“…Some studies used figure drawings depicting progressively larger body shapes as proxy measures of body size at certain age periods [26][27][28][29][30]. In some cases, studies assessed only weight at the late adolescent period, relying mainly on participants' retrospective recall of their weight during a period of adolescence, and current height was either self-reported or measured to calculate BMI [31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50]. Measured height and weight from childhood or adolescence were available in a small subset of studies [51][52][53][54][55][56][57][58][59][60][61].…”

Section: Weight and Cancermentioning

confidence: 99%

Weight, Dietary Behavior, and Physical Activity in Childhood and Adolescence: Implications for Adult Cancer Risk

2009

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Lifestyle factors related to energy balance, including weight, dietary behavior and physical activity, are as-sociated with cancer risk. The period of childhood and growth into adolescence and early adulthood may re-present a ‘cumulative risk’ for later adult-onset cancers. We review a number of epidemiologic studies that have examined associations among childhood and adolescent body size, diet, and physical activity with adult cancer risk. These studies suggest that unhealthy behaviors that develop early in life and persist over time may increase the risk of some cancer types, such as premenopausal breast, ovarian, endometrial, colon and renal cancer, adversely affect cancer-related morbidities, and increase mortality. Continued research is needed to further determine and refine how timing and degree of such exposures in early childhood and adolescence relate to adult cancer risk. Presently, sufficient evidence suggests a continued need for stronger primary prevention in cancer and obesity research via modified lifestyle behaviors earlier in the developmental spectrum, i.e. during childhood and adolescence.

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Section: Weight and Cancermentioning

confidence: 99%

Weight, Dietary Behavior, and Physical Activity in Childhood and Adolescence: Implications for Adult Cancer Risk

2009

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“…1,2 With the obesity rate on the rise, it is likely that RCC will be diagnosed in more obese patients. A standard treatment modality for small renal masses is nephronsparing surgery.…”

Section: Introductionmentioning

confidence: 99%

Robotic partial nephrectomy for renal tumours in obese patients: Perioperative outcomes in a multi-institutional analysis

Abdullah

Dalela

Barod

et al. 2015

CUAJ

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E859Cite as: Can Urol Assoc J 2015;9(11-12):E859-62. http://dx.doi.org/10.5489/cuaj.3197 Published online December 14, 2015. AbstractIntroduction: We sought to evaluate the association of obesity with surgical outcomes of robotic partial nephrectomy (RPN) using a large, multicentre database. 2 ). Patient characteristics and outcomes were compared between obese and non-obese patients. Multivariable analysis was used to assess the association of obesity on RPN outcomes. Results: A total of 806 (44%) patients were obese with median BMI of 33.8kg/m 2 . Compared to non-obese patients, obese patients had greater median tumour size (2.9 vs. 2.5cm, p<0.001), mean RENAL nephrometry score (7.3 vs. 7.1, p=0.04), median operating time (176 vs. 165 min, p=0.002), and median estimated blood loss (EBL, 150 vs. 100 ml, p=0.002), but no difference in complications. Obesity was not an independent predictor of operative time or EBL on regression analysis. Among obese patients, males had a greater EBL (150 vs. 100 ml, p<0.001), operative time (180 vs. 166 min, p<0.001) and warm ischemia time (WIT, 20 vs. 18, p=0.001), and male sex was an independent predictor of these outcomes on regression analysis. Conclusions:In this large, multicentre study on RPN, obesity was not associated with increased complications and was not an independent predictor of operating time or blood loss. However, in obese patients, male gender was an independent predictor of greater EBL, operative time, and WIT. Our results indicate that obesity alone should not preclude consideration for RPN.

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“…59,60,62,65,70,71,78,[83][84][85] Most studies have found an association with elevated body mass index (BMI) among both men and women, and abdominal obesity, as indicated by waist-to-hip ratio, 58,65,70,71,85 may play an important role in this association, particularly among women. A quantitative review of the published literature reported a summary relative risk for renal cell cancer of 1.07 per unit increase of BMI.…”

Section: Obesitymentioning

confidence: 99%

Epidemiologic characteristics and risk factors for renal cell cancer

McLaughlin¹

2009

CLEP

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Abstract:Incidence rates of renal cell cancer, which accounts for 85% of kidney cancers, have been rising in the United States and in most European countries for several decades. Family history is associated with a two-to four-fold increase in risk, but the major forms of inherited predisposition together account for less than 4% of renal cell cancers. Cigarette smoking, obesity, and hypertension are the most consistently established risk factors. Analgesics have not been convincingly linked with renal cell cancer risk. A reduced risk of renal cell cancer among statin users has been hypothesized but has not been adequately studied. A possible protective effect of fruit and vegetable consumption is the only moderately consistently reported dietary fi nding, and, with the exception of a positive association with parity, evidence for a role of hormonal or reproductive factors in the etiology of renal cell cancer in humans is limited. A recent hypothesis that moderate levels of alcohol consumption may be protective for renal cell cancer is not strongly supported by epidemiologic results, which are inconsistent with respect to the categories of alcohol consumption and the amount of alcohol intake reportedly associated with decreased risk. For occupational factors, the weight of the evidence does not provide consistent support for the hypotheses that renal cell cancer may be caused by asbestos, gasoline, or trichloroethylene exposure. The established determinants of renal cell cancer, cigarette smoking, obesity, and hypertension, account for less than half of these cancers. Novel epidemiologic approaches, including evaluation of gene-environment interactions and epigenetic mechanisms of inherited and acquired increased risk, are needed to explain the increasing incidence of renal cell cancer. Keywords: renal cell cancer, epidemiology, risk factor, review Descriptive epidemiologyKidney cancer is the ninth most common cancer in developed countries.1 Approximately 85% of kidney cancers are renal parenchyma (renal cell) cancers, while the remainder for the most part are urothelial cancers of the renal pelvis.2 Approximately 80% of renal cell cancers are clear cell adenocarcinomas, the remainder being papillary (∼15%), chromophobe (∼5%), and collecting duct carcinomas (Ͻ1%). Both renal cell and renal pelvis cancers are about twice as common among men as among women, [1][2][3] with the mean age at diagnosis in the early 60s for renal cell cancer and in the late 60s for renal pelvis cancer. For renal pelvis cancer, there is a strong tendency to develop multiple transitional epithelial tumors, particularly in the urinary bladder and ureter. 4 For the most part, renal pelvis cancer parallels bladder cancer in epidemiologic characteristics and risk factors and has been addressed by the authors elsewhere.

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Body Size and Renal Cell Cancer Incidence in a Large US Cohort Study

Cited by 162 publications

References 41 publications

Weight, Dietary Behavior, and Physical Activity in Childhood and Adolescence: Implications for Adult Cancer Risk

Weight, Dietary Behavior, and Physical Activity in Childhood and Adolescence: Implications for Adult Cancer Risk

Robotic partial nephrectomy for renal tumours in obese patients: Perioperative outcomes in a multi-institutional analysis

Epidemiologic characteristics and risk factors for renal cell cancer

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