Body temperature is a more important modulator of lifespan than metabolic rate in two small mammals

Zhao, Zhanzheng; Cao, Jing; Niu, Chaoqun; Bao, Meng-Huan; Xu, Jiaqi; Huo, Da-Liang; Liao, Sha-Sha; Liu, Wei; Speakman, John R.

doi:10.1038/s42255-022-00545-5

Cited by 39 publications

(23 citation statements)

References 31 publications

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“…The suggestion that mice in general should be housed at 30 °C [ 65 , 66 , 68 ] is clearly inappropriate (at least for this outbred strain) since for these mice 30 °C is already at the lower critical temperature, an ambient temperature that humans routinely avoid. As we have shown recently, housing this strain at 32.5 °C shortens their lifespan significantly, relative to those kept at 21 °C [ 71 ] illustrating there are negative health impacts of keeping rodents at high ambient temperatures.…”

Section: Discussionmentioning

confidence: 84%

Effects of ambient temperatures between 5 and 35 °C on energy balance, body mass and body composition in mice

Zhao

Yang

et al. 2022

Molecular Metabolism

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Section: Discussionmentioning

confidence: 84%

Effects of ambient temperatures between 5 and 35 °C on energy balance, body mass and body composition in mice

Zhao

Yang

et al. 2022

Molecular Metabolism

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“…However, recent work in rodents suggests that temperature, rather than MR, may be a more important determinant of lifespan (Zhao et al, 2022). Elevating body temperature reduces lifespan, even in the context of reduced MR.…”

Section: Discussionmentioning

confidence: 99%

Accelerating the clock: Interconnected speedup of energetic and molecular dynamics during aging in cultured human cells

Sturm

Bobba-Alves

Tumasian

et al. 2022

Preprint

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The allometric theory of metabolism predicts that the rate of biological aging is proportional to an organism’s size and metabolic rate (MR). Here we test this hypothesis in humans by generating longitudinal, multi-modal signatures of aging in primary human fibroblasts. Relative to metabolic rates in the human body, isolated cells exhibit markedly elevated MR and operate closer to their maximal energy production capacity. Accordingly, per-cell division, isolated cells display accelerated telomere shortening and increased rate of DNA methylation aging. Moreover, despite a marked reduction in division rate towards the end of life, mass-specific MR increases exponentially, reflecting hypermetabolism. We develop a theoretical-mathematical model that accounts for a partitioning of energetic costs related to both growth or maintenance, quantifying the potential origins of hypermetabolism in vitro, and with advancing age. Moreover, we define genome-wide molecular rescaling factors that confirm and quantify the systematic acceleration of molecular aging kinetics in cultured fibroblasts, and use this approach to show how metabolic and pharmacological manipulations that increase or decrease MR predictably accelerate or decelerate the rates of biological aging. The interconnected speedup of energetic and molecular dynamics across the lifespan of human cells has important theoretical and clinical implications for aging biology.

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“…Regulative NST (NSTr) was calculated as NST max minus RMR. All measurements were performed between 1000 and 1700 to correct for a possible effect of the circadian rhythm (Zhao et al 2022).…”

Section: Metabolic Trailsmentioning

confidence: 99%

“…Alternatively, when the temperature rises above the upper-critical temperature of the TNZ, metabolic rate increases due to energy spent on evaporative cooling (IUPS Thermal Commission 2001;Gordon 2012;Speakman & Keijer 2013). The TNZ describes the relationship between metabolic heat production and ambient temperature, providing information on an animal's energetic requirements and ability to live and survive in different climates (Gordon 2012;Zhao et al 2022).…”

Section: Introductionmentioning

confidence: 99%

Temperature determines the shift of thermal neutral zone and influences thermogenic capacity in striped hamsters

et al. 2022

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The thermoneutral zone (TNZ) reflects the adaptation of mammals to their natural habitat. However, it remains unclear how TNZ shifts in response to variations in ambient temperature. To test the hypothesis that ambient temperature plays a key role in determining TNZ variations between seasons, we measured metabolic rate, body temperature, and cytochrome c oxidase (COX) activity of several visceral organs in striped hamsters (Cricetulus barabensis) either acclimated to semi‐natural conditions over a year, or subjected to a gradual decrease in mean temperature from 30 ± 1°C to −15 ± 1°C. The TNZ range in striped hamsters differed seasonally, with a wider TNZ and a lower lower‐critical temperature in winter compared to summer. The hamsters showed a considerable leftward shift of lower‐critical temperature from 30°C to 20°C after the ambient temperature of acclimation from 30°C down to −15°C, whereas the upper‐critical temperature of TNZ remained fixed at 32.5°C. The resting metabolic rate in thermoneutral zone (RMRt), nonshivering thermogenesis (NST), and COX activity of brown adipose tissue, liver, skeletal muscle, brain, and kidneys, increased significantly in hamsters acclimated at lower ambient temperatures. Following acute exposure to 5°C and −15°C, hamsters acclimated to 32.5°C had significantly lower maximal NST and lower serum thyroid tri‐iodothyronine (T3) levels compared to those kept at 23°C. These findings suggest that acclimation to the upper‐critical temperature of TNZ impairs the hamsters’ thermogenic capacity to cope with extreme cold temperature. Reduced ambient temperature was mainly responsible for the leftward shift of TNZ in striped hamsters, which reflects the adaptation to cold environments.

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Body temperature is a more important modulator of lifespan than metabolic rate in two small mammals

Cited by 39 publications

References 31 publications

Effects of ambient temperatures between 5 and 35 °C on energy balance, body mass and body composition in mice

Effects of ambient temperatures between 5 and 35 °C on energy balance, body mass and body composition in mice

Accelerating the clock: Interconnected speedup of energetic and molecular dynamics during aging in cultured human cells

Temperature determines the shift of thermal neutral zone and influences thermogenic capacity in striped hamsters

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