Bon usage des antibiotiques: étude prospective sur l'utilisation du linézolide dans un hôpital universitaire français

Synthesis, characterization, and cytotoxic activity studies of new N4O complexes derived from 2‐({3‐[2‐morpholinoethylamino]‐N3‐([pyridine‐2‐yl]methyl) propylimino} methyl)phenol

“…The chloroform was removed by rotary evaporation to leave the product as a brown oil (Scheme 1 (d, 1H, H-n). 13 ethanol (20 mL) was added dropwise to a solution of 2-hydroxybenzaldehyde (0.5 mmol, 0.061 g) in ethanol (50 mL), while stirring. The mixture was refluxed while stirring for 12 h. After cooling to room temperature, a brown oil was obtained.…”

“…Schiff base compounds derived from morpholine are completely stable in biological systems, allowing rigorous long-term application; therefore, they are attracting increasing attention in the design of ligands and their metal complexes for their potential anticancer applications [12] . Many morpholine derivatives display antibacterial [13][14][15][16] , anticancer [9] , antimicrobial [17] , antidiabetic [18] , anticholinergic [18] and anti-inflammatory [19] activities. Schiff bases of 4-(4-aminophenyl)morpholine also possess potent antimicrobial activities [20,21] .…”

“…13 C NMR (CD 3 CN, ppm) δ = 26.69 (c-f'); 51.67 (c-e', c-c'); 56.40 (c-b'); 57.95 (c-d', g', i'); 63.63 (c-a'); 113.85 (c-s); 118.36 (c-m); 122.48 (c-q); 124.56(ck); 124.73 (c-o); 134.79 (c-r); 135.93 (c-p); 140.96 (c-l); 148.96 (c-n); 155.50 (c-h); 170.48 (c-j); 172.73 (c-t).…”

Spectroscopic study of solvent effects on the electronic absorption spectra of morpholine and its complexes

“…Morpholine is an organic compound with ether-like properties due to the presence of an oxygen atom and aminelike properties due to the presence of a nitrogen atom (Figure 1). Many molecules derived from morpholines have very good biological activity in different therapeutic areas, such as antiviral, antibacterial, anticancer, antidiabetic, antimicrobial, antimalarial, inflammatory, and antifungal activities [1,2]. The most important applications of complexes are drugs; therefore, they must dissolve in the proper solvent.…”