Bone Abnormalities in Gardner's Syndrome

The occult osteomatous changes in the mandible in patients with familial polyposis coli

“…A thorough review of the world literature revealed a very high incidence of osteoma in the mandible (Chang et al, 1968;Utsunomiya et al, 1972) and the frequent appearance of abnormal dental growth (Fader et al, 1962) in cases which were reported as typical 'Gardner's syndrome' (synonymous with FPC with complete Gardner's syndrome as mentioned later in the present paper). We therefore decided to carry out radiological examination of the oral region on a routine basis in patients diagnosed as having FPC, and observed peculiar radio-opaque lesions detectable only by detailed dentomaxillar radiological examination techniques even in the cases without manifested associated changes.…”

Bone Lesions

“…A link to the chromosome 7q33 region was demonstrated in families with a high incidence of chordomas, particularly those of the skull base. In this study, chondroid chordoma showed a normal karyotype, whereas in conventional chordoma, there were complex numerical and structural aberrations involving chromosomes 1, 2, 3, 5, 8,9,11,15,19,20, and X. Dedifferentiated chordomas were polyploid with a complex karyotype of 71 to 123 chromosomes. [337][338][339] Gil and colleagues 340 recently reported cytogenetic differences between three histologic variants of clival chordoma.…”

“…9 Among 1243 chondromas in four large series, only four (0.32%) were in the head and neck region. In more than 10,000 bone lesions at the Mayo Clinic, there were no cases of enchondroma in the jaw or facial bones.…”

Unilateral Chest Wall Anomaly in a Patient with Gardner's Syndrome: Case Report

“…More than half of patients with FAP or Gardner syndrome have osseous involvement (7). The most common bone abnormalities observed in patients with Gardner syndrome are osteomas consisting of dense osseous lesions originating on the bone surface (6). Almost all parts of the skeletal system may be in-…”