Bone-adiposity cross-talk: implications for pediatric obesity

Chaplais, Elodie; Torgerson, David; Greene, David; Dutheil, Frédéric; Duché, Pascale; Naughton, Géraldine; Courteix, Daniel

doi:10.1007/s00774-015-0654-6

Cited by 13 publications

(8 citation statements)

References 61 publications

(111 reference statements)

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“…52 However, increasing evidence has shown that obesity could be a risk factor for osteoporosis. 52,53 Here, we showed a significant bone loss in HFD-induced obesity mice ( Figure 5), in line with reports that obesity is associated with bone loss. 52 We also discovered an inverse correlation between Lox and bone markers in both NCD and HFD mice ( Figure 5).…”

Section: Discussionsupporting

confidence: 91%

A Lox/CHOP‐10 crosstalk governs osteogenic and adipogenic cell fate by MSCs

Jiang

Xing

Wang

et al. 2018

J Cellular Molecular Medi

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Accelerated marrow adipogenesis has been associated with ageing and osteoporosis and is thought to be because of an imbalance between adipogenic and osteogenic differentiation of mesenchymal stem cell (MSCs). We have previously found that lysyl oxidase (Lox) inhibition disrupts BMP4‐induced adipocytic lineage commitment and differentiation of MSCs. In this study, we found that lox inhibition dramatically up‐regulates BMP4‐induced expression of CCAAT/enhancer binding protein (C/EBP) homologous protein 10 (CHOP‐10), which then promotes BMP4‐induced osteogenesis of MSCs both in vitro and in vivo. Specifically, Lox inhibition or CHOP‐10 up‐regulation activated Wnt/β‐catenin signalling to enhance BMP4‐induced osteogenesis, with pro‐adipogenic p38 MAPK and Smad signalling suppressed. Together, we demonstrate that Lox/CHOP‐10 crosstalk regulates BMP4‐induced osteogenic and adipogenic fate determination of MSCs, presenting a promising therapeutic target for osteoporosis and other bone diseases.

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Section: Discussionsupporting

confidence: 91%

A Lox/CHOP‐10 crosstalk governs osteogenic and adipogenic cell fate by MSCs

Jiang

Xing

Wang

et al. 2018

J Cellular Molecular Medi

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“…Fat tissue is an active endocrine organ secreting a host of molecules called adipokines, such as leptin. We have demonstrated the likelihood of bone-adiposity cross-talk in a recent literature review [ 46 ]. We were unable to report that insulin, pro-inflammatory cytokines, adiponectin, PAI-1, nor even bone metabolism markers were predictor variables of weight loss.…”

Section: Discussionmentioning

confidence: 99%

Multilevel Approach of a 1-Year Program of Dietary and Exercise Interventions on Bone Mineral Content and Density in Metabolic Syndrome – the RESOLVE Randomized Controlled Trial

et al. 2015

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BackgroundWeight loss is a public health concern in obesity-related diseases such as metabolic syndrome (MetS). However, restrictive diets might induce bone loss. The nature of exercise and whether exercise with weight loss programs can protect against potential bone mass deficits remains unclear. Moreover, compliance is essential in intervention programs. Thus, we aimed to investigate the effects that modality and exercise compliance have on bone mineral content (BMC) and density (BMD).MethodsWe investigated 90 individuals with MetS who were recruited for the 1-year RESOLVE trial. Community-dwelling seniors with MetS were randomly assigned into three different modalities of exercise (intensive resistance, intensive endurance, moderate mixed) combined with a restrictive diet. They were compared to 44 healthy controls who did not undergo the intervention.ResultsThis intensive lifestyle intervention (15–20 hours of training/week + restrictive diet) resulted in weight loss, body composition changes and health improvements. Baseline BMC and BMD for total body, lumbar spine and femoral neck did not differ between MetS groups and between MetS and controls. Despite changes over time, BMC or BMD did not differ between the three modalities of exercise and when compared with the controls. However, independent of exercise modality, compliant participants increased their BMC and BMD compared with their less compliant peers. Decreases in total body lean mass and negative energy balance significantly and independently contributed to decreases in lumbar spine BMC.ConclusionAfter the one year intervention, differences relating to exercise modalities were not evident. However, compliance with an intensive exercise program resulted in a significantly higher bone mass during energy restriction than non-compliance. Exercise is therefore beneficial to bone in the context of a weight loss program.Trial RegistrationClinicalTrials.gov NCT00917917

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“…The prevalence of paediatric overweight and obesity remains alarming worldwide (15) , accompanied by early metabolic (24) , sleep (25,26) and functional (27) impairments, amongst others, calling for effective preventive and treatment strategies.…”

Section: Discussionmentioning

confidence: 99%

Comparison between type A and type B early adiposity rebound in predicting overweight and obesity in children: a longitudinal study

et al. 2020

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Early adiposity rebound (EAR) predicts paediatric overweight/obesity, but current approaches do not consider both the starting point of EAR and the BMI trajectory. We compared the clinical characteristics at birth, age 3–5 and 6–8 years of children, according to the EAR and to its type (type A/type B-EAR). We assessed the childrenʼs odds of being classified as overweight/obese at age 6–8 years, according to the type of EAR as defined at age 3–5 years. As part of this two-wave observational study, 1055 children were recruited and examined at age 3–5 years. Antenatal and postnatal information was collected through interviews with parents, and weight and height from the health records. Type A and type B-EAR were defined in wave 1 according to the BMI nadir and the variation of BMI z-score between the starting point of the adiposity rebound and the last point on the curve. At 6–8 years (wave 2), 867 children were followed up; 426 (40·4 %) children demonstrated EAR. Among them, 172 had type A-EAR, higher rates of parental obesity (P < 0·05) and greater birth weight compared with other children (P < 0·001). Odds for overweight/obesity at 6–8 years, when adjusting for antenatal and postnatal factors, was 21·35 (95 % CI 10·94, 41·66) in type A-EAR children and not significant in type B-EAR children (OR 1·76; 95 % CI 0·84, 3·68) compared with children without EAR. Classification of EAR into two subtypes provides physicians with a reliable approach to identify children at risk for overweight/obesity before the age of 5 years.

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Bone-adiposity cross-talk: implications for pediatric obesity

Cited by 13 publications

References 61 publications

A Lox/CHOP‐10 crosstalk governs osteogenic and adipogenic cell fate by MSCs

A Lox/CHOP‐10 crosstalk governs osteogenic and adipogenic cell fate by MSCs

Multilevel Approach of a 1-Year Program of Dietary and Exercise Interventions on Bone Mineral Content and Density in Metabolic Syndrome – the RESOLVE Randomized Controlled Trial

Comparison between type A and type B early adiposity rebound in predicting overweight and obesity in children: a longitudinal study

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