Bone biomaterials for overcoming antimicrobial resistance: Advances in non-antibiotic antimicrobial approaches for regeneration of infected osseous tissue

Sadowska, Joanna M.; Genoud, Katelyn J.; Kelly, Daniel J.; O’Brien, Fergal J.

doi:10.1016/j.mattod.2020.12.018

Cited by 82 publications

(53 citation statements)

References 325 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…POMs are generally difficult to be synthesized, involving either solvothermal or hydrothermal methods requiring high pressure and temperature (implying high energy consumption) or ones using toxic organic solvents (incompatible with the development of green chemistry) [35,39,[52][53][54]. We carefully selected the method based on each POM's specifics, sometimes modifying protocols mentioned in literature [3,12,14,16,18,22,30,53].…”

Section: Synthesis Of Polyoxometalatesmentioning

confidence: 99%

“…Initially we employed the two-step method, involving the ligand synthesis followed by the cluster formation, for synthesizing ten POMs, i.e., the Keggin (saturated/monolacunary) structures with mixed addenda atoms, the mono-lacunary Wells-Dawson polyoxometalate with mixed addenda atoms, and the six clusters-type structures. Certain molar ratios of organic and organometallic fragments or transition-metal cations were carefully calculated according to the reactions' stoichiometry [12,22,30,36,54]. An important aspect in the first stage was to obtain a ligand precipitate of high purity.…”

Section: Synthesis Of Polyoxometalatesmentioning

confidence: 99%

See 1 more Smart Citation

In Vitro Antibacterial Susceptibility of Different Pathogens to Thirty Nano-Polyoxometalates

et al. 2021

View full text Add to dashboard Cite

Due to their unique properties, nano-polyoxometalates (POMs) can be alternative chemotherapeutic agents instrumental in designing new antibiotics. In this research, we synthesized and characterized “smart” nanocompounds and validated their antibacterial effects in order to formulate and implement potential new drugs. We characterized thirty POMs in terms of antibacterial activity–structure relationship. The antibacterial effects of these compounds are directly dependent upon their structure and the type of bacterial strain tested. We identified three POMs that presented sound antibacterial activity against S. aureus, B. cereus, E. coli, S. enteritidis and P. aeruginosa strains. A newly synthesized compound K6[(VO)SiMo2W9O39]·11H2O (POM 7) presented antibacterial activity only against S. aureus (ATCC 6538P). Twelve POMs exerted antibacterial effects against both Gram-positive and Gram-negative strains. Only one POM (a cluster derivatized with organometallic fragments) exhibited a stronger effect compared to amoxicillin. New studies in terms of selectivity and specificity are required to clarify these extremely important aspects needed to be considered in drug design.

show abstract

Section: Synthesis Of Polyoxometalatesmentioning

confidence: 99%

Section: Synthesis Of Polyoxometalatesmentioning

confidence: 99%

In Vitro Antibacterial Susceptibility of Different Pathogens to Thirty Nano-Polyoxometalates

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Nesse contexto, algumas estratégias foram desenvolvidas para minimizar ou evitar a ocorrência de infecções, além de se constituir como uma alternativa aos antibióticos convencionais, que têm ocasionado o surgimento de bactérias super-resistentes (Azam et al, 2012;Sadowska et al, 2021;Yuan et al, 2021). Nos últimos anos, alguns biomateriais com revestimentos contendo antibióticos, surfactantes e aqueles intrinsecamente bactericidas já apresentam resultados de ensaios clínicos (Shah et al, 2015).…”

Section: Contudo Bactérias Como Pseudomonas Aeruginosa Escherichia Coliunclassified

Adição simultânea de nanopartículas de Cu e Sr em nanotubos de TiO2 sobre implantes de titânio: estudo de molhabilidade

Mendes

Cavalcante

Tavares

et al. 2021

CONJ

View full text Add to dashboard Cite

A adição simultânea do Cu e Sr nos revestimentos de TiO2 sobre implantes de titânio pode resultar num biomaterial especializado, por conjugar as propriedades bactericidas e osteogênicas desses metais, respectivamente. O efeito desses metais na molhabilidade desses revestimentos foi avaliado. A anodização, o recozimento e a incorporação dos metais reduziram o ângulo de contato, aumentando a energia superficial, sugerindo que este revestimento pode elevar a bioatividade do implante de titânio.

show abstract

“…Osteomyelitis, the bacterial infection of bone or bone marrow occurring in open fracture, chronic inflammation, has always been a clinical challenge. [1,2] Especially, chronic osteomyelitis is very difficult to treat and in bone destruction, disability, or fatal applied to treat osteomyelitis efficiently. To avoid hyperthermia, mild and noninvasive US for medical imaging is expected to be used in sonodynamic therapy (SDT).…”

Section: Introductionmentioning

confidence: 99%

Ultrasonic Interfacial Engineering of MoS₂‐Modified Zn Single‐Atom Catalysts for Efficient Osteomyelitis Sonodynamic Ion Therapy

Feng

Lei

et al. 2021

Small

View full text Add to dashboard Cite

sepsis. Nearly 40% Patients suffered from bone infection have the risk of recurrence and chronic infection. [3] Clinical treatments for osteomyelitis involve the long-term and high-dose antibiotics administration, as well as multiple surgical debridement. [4] However, the notable problems of these approaches are obvious. The overuse of antibiotics not only brings severe side effects, but also causes drug-resistant. [5] The removed bone tissue by debridement will weaken the musculoskeletal support and lead to unaesthetic disfigurements. [1] Recent studies showed that controlling antibiotic delivery from nanoparticles or hydrogels could improve the antibacterial efficiency and reduce the dosage of antibiotics, however, superbugs infection still cannot be eliminated efficiently. [6] Given these obstacles, using an antibiotics-free, in situ, and rapid strategy to treat drugresistance bacteria induced osteomyelitis is highly desirable. Photodynamic and photothermal therapies have been intensively reported to treat osteomyelitis, [1,7] but the limited penetration depth of light (visible or near infrared light) cannot fulfill the treatment request of patients with deep bone marrow infection. Alternatively, exogenous stimuli like ultrasound (US) and microwave have strong penetrating ability. [8] Our group recently reported that sonodynamic [9] and microwave therapies [10] can beThe ORCID identification number(s) for the author(s) of this article can be found under

show abstract

Bone biomaterials for overcoming antimicrobial resistance: Advances in non-antibiotic antimicrobial approaches for regeneration of infected osseous tissue

Cited by 82 publications

References 325 publications

In Vitro Antibacterial Susceptibility of Different Pathogens to Thirty Nano-Polyoxometalates

In Vitro Antibacterial Susceptibility of Different Pathogens to Thirty Nano-Polyoxometalates

Adição simultânea de nanopartículas de Cu e Sr em nanotubos de TiO2 sobre implantes de titânio: estudo de molhabilidade

Ultrasonic Interfacial Engineering of MoS₂‐Modified Zn Single‐Atom Catalysts for Efficient Osteomyelitis Sonodynamic Ion Therapy

Contact Info

Product

Resources

About

Bone biomaterials for overcoming antimicrobial resistance: Advances in non-antibiotic antimicrobial approaches for regeneration of infected osseous tissue

Cited by 82 publications

References 325 publications

In Vitro Antibacterial Susceptibility of Different Pathogens to Thirty Nano-Polyoxometalates

In Vitro Antibacterial Susceptibility of Different Pathogens to Thirty Nano-Polyoxometalates

Adição simultânea de nanopartículas de Cu e Sr em nanotubos de TiO2 sobre implantes de titânio: estudo de molhabilidade

Ultrasonic Interfacial Engineering of MoS2‐Modified Zn Single‐Atom Catalysts for Efficient Osteomyelitis Sonodynamic Ion Therapy

Contact Info

Product

Resources

About

Ultrasonic Interfacial Engineering of MoS₂‐Modified Zn Single‐Atom Catalysts for Efficient Osteomyelitis Sonodynamic Ion Therapy