Bone composition and healing: Open electromagnetic and biomechanical problems

Biggane, Peter; Jackson, Xavier; Nazarian, Ara

doi:10.1109/embc.2016.7592102

Cited by 1 publication

(4 citation statements)

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“…At two weeks following surgery, the mechanical strength of femurs was higher in HF-PEMF compared to control group (35.1 N ± 5.6 vs. 21.83 N ± 4.2, p = 0.03), and the elastic deformation until fracture was smaller [0.7 ± 0.06 mm HF-PEMF vs. 1.03 ± 0.12 mm control, p < 0.01] ( Figure 5A).…”

Section: Three-point Bending Testmentioning

confidence: 93%

“…PEMF treatments vary in EMF frequency, pulse duration/shape, duration of exposure, and type of stimulator [21]. Depending on the configuration and dose of electric or electromagnetic input, different transmembrane signaling mechanisms may be activated in target cells.…”

mentioning

confidence: 99%

“…Depending on the configuration and dose of electric or electromagnetic input, different transmembrane signaling mechanisms may be activated in target cells. Previous studies have shown that the maximum effective frequency range of PEMFs for humans is between 1 and 50 Hz, while frequencies >100 Hz are not effective and result in osteoclastogenesis [21]. In PEMFs, longer intervals between pulses eliminate heat, producing a nonthermal biological effect [22].…”

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confidence: 99%

“…Clinical studies in the fields of orthopedics and traumatology showed that PEMF therapy decreases edema, reduces pain and wound healing time [5], as well as accelerates hematoma resolution [24] and bone consolidation [21]. It is wellknown that callus formation is stimulated by controlled micromovements applied to the fracture focus.…”

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Enhancement of bone consolidation using high-frequency pulsed electromagnetic fields (HF-PEMFs): An experimental study on rats

Oltean‐Dan

Dogaru

Apostu

et al. 2019

Bosn J of Basic Med Sci

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In vitro studies showed that high-frequency pulsed electromagnetic fields (HF-PEMFs) increase the activity/expression of early and late osteogenic markers and enhance bone mineralization. The main aim of this study was to investigate the in vivo effects of HF-PEMFs on fracture healing using a rat model. A femur fracture was established by surgery in 20 male Wistar rats. Titanium nails were implanted to reduce and stabilize the fracture. After surgery, 20 rats were equally divided into untreated control and treated group (from the first postoperative day HF-PEMFs at 400 pulses/sec [pps] were applied for 10 minutes/day, for two weeks). Quantitative and qualitative assessment of bone formation was made at two and eight weeks following surgery and included morphological and histological analysis, serological analysis by ELISA, micro-computed tomography (micro-CT), and three-point bending test. At two weeks in HF-PEMF group, soft callus was at a more advanced fibrocartilaginous stage and the bone volume/total tissue volume (BV/TV) ratio in the callus area was significantly higher compared to control group (p = 0.047). Serum concentration of alkaline phosphatase (ALP) and osteocalcin (OC) was significantly higher in HF-PEMF group (ALP p = 0.026, OC p = 0.006) as well as the mechanical strength of femurs (p = 0.03). At eight weeks, femurs from HF-PEMF group had a completely formed woven bone with dense trabeculae, active bone marrow, and had a significantly higher BV/TV ratio compared to control (p = 0.01). HF-PEMFs applied from the first postoperative day, 10 minutes/day for two weeks, enhance bone consolidation in rats, especially in the early phase of fracture healing.

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Section: Three-point Bending Testmentioning

confidence: 93%

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confidence: 99%

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