Bone composition: relationship to bone fragility and anti-osteoporotic
                        drug effects

Boskey, Adele L.

doi:10.1038/bonekey.2015.79

Cited by 21 publications

(20 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bone is a dynamic and heterogeneous tissue consisting of different constituents viz. mineral phase (hydroxyapatite), organic phase (∼90% collagen type I, ∼5% noncollagenous proteins, ∼2% lipids) and water 44 , 45 . With the advancement of age, gender and diet their relative proportions in the bone vary significantly.…”

Section: Discussionmentioning

confidence: 99%

“…The bone has heterogeneous composition due to its constant remodelling and mineralization cycles. Loss of material heterogeneity is associated with an increase in brittleness thereby increasing the risk of fracture 44 . Thus, the physiological composition of the bone in the healthy individual must be maintained for proper functioning of bones.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

High dietary salt intake correlates with modulated Th17-Treg cell balance resulting in enhanced bone loss and impaired bone-microarchitecture in male mice

Dar

Singh

Shukla

et al. 2018

Sci Rep

View full text Add to dashboard Cite

Osteoporosis is associated with reduced density and quality of bone leading to weakened skeleton thereby increasing the risk of fractures responsible for increased morbidity and mortality. Due to preference for western food style the consumption of salt intake in our diets has increased many folds. High dietary salt intake has recently been linked with induction of Th17 cells along with impairment of Treg cells. Also, Th17 cells have been one of major players in the pathophysiology of various bone pathologies including osteoporosis. We thus hypothesized that high salt diet (HSD) intake would lead to enhanced bone loss by modulating Th17-Treg cell balance. In the present study, we report for the first time that HSD intake in male mice impairs both trabecular and cortical bone microarchitecture along with decreasing the mineral density and heterogeneity of bones. The HSD modulates host immune system and skews Treg-Th17 balance by promoting osteoclastogenic Th17 cells and inhibiting development of anti-osteoclastogenic Treg cells in mice. HSD also enhanced expression of proinflammatory cytokines (IL-6, TNF-α, RANKL and IL-17) and decreased the expression of anti-inflammatory cytokines (IL-10, IFN-γ). Taken together the present study for the first time establishes a strong correlation between high dietary salt intake and bone health via interplay between Th17-Treg cells.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

High dietary salt intake correlates with modulated Th17-Treg cell balance resulting in enhanced bone loss and impaired bone-microarchitecture in male mice

Dar

Singh

Shukla

et al. 2018

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Nature bones possess complex hierarchical architecture with two main components, collagen and hydroxyapatite [ 9 – 11 ]. In bone tissue engineering, fabricating an ideal biomimicry of the bone extracellular matrix accommodating for cell adhesion and proliferation for the treatment of malfunction is still a challenge [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Graphene Oxide Hybridized nHAC/PLGA Scaffolds Facilitate the Proliferation of MC3T3-E1 Cells

et al. 2018

View full text Add to dashboard Cite

Biodegradable porous biomaterial scaffolds play a critical role in bone regeneration. In this study, the porous nano-hydroxyapatite/collagen/poly(lactic-co-glycolic acid)/graphene oxide (nHAC/PLGA/GO) composite scaffolds containing different amount of GO were fabricated by freeze-drying method. The results show that the synthesized scaffolds possess a three-dimensional porous structure. GO slightly improves the hydrophilicity of the scaffolds and reinforces their mechanical strength. Young’s modulus of the 1.5 wt% GO incorporated scaffold is greatly increased compared to the control sample. The in vitro experiments show that the nHAC/PLGA/GO (1.5 wt%) scaffolds significantly cell adhesion and proliferation of osteoblast cells (MC3T3-E1). This present study indicates that the nHAC/PLGA/GO scaffolds have excellent cytocompatibility and bone regeneration ability, thus it has high potential to be used as scaffolds in the field of bone tissue engineering.Electronic supplementary materialThe online version of this article (10.1186/s11671-018-2432-6) contains supplementary material, which is available to authorized users.

show abstract

“…The white particles were not analysed separately but taken into account the high amount of bone pieces in the sediment, they most probably consisted of undissolved bone as well as precipitated calcium compounds. Based on the calcium content of the original sediment, 79 to 129% of the calcium input was found in the solid fraction in all processing conditions, which indicated low dissolution and possible precipitation [12]. The values exceeding 100% are most likely caused by inaccuracies in the used analytical methods due to challenging analysable matrix.…”

Section: Resultsmentioning

confidence: 97%

Poultry By-products as a Potential Source of Nutrients

Jorde¹,

Sollid²,

Svartberg³

et al. 2018

Adv Recycling Waste Manag

View full text Add to dashboard Cite

Large amounts of bones and trimmings are generated as a by-product of the poultry industry in mechanical deboning of chicken. These by-products are potential sources of valuable components such as proteins and nutrients. Enzymatic hydrolysis of animal by-products can be used to separate lipids and produce protein hydrolyzates resulting in the formation of insoluble sediment rich in phosphorus and nitrogen. In this study, the sediment from the enzymatic hydrolysis of by-product from mechanical deboning of chicken is hydrothermally treated to evaluate the possibility for nutrient recycling. Hydrothermal processing was performed at elevated temperature of 150°C and 220°C using water as the reaction medium with varying pH and time. The elemental composition of the liquid and solid fractions was measured after the treatments. With higher pH, the majority of phosphorus was distributed to the solid fraction while with pH 1 the majority of phosphorus was found in the liquid fraction. Nitrogen was concentrated in the liquid fraction in all processing conditions. The major part of the carbon was distributed to the liquid fraction.

show abstract

Bone composition: relationship to bone fragility and anti-osteoporotic drug effects

Cited by 21 publications

References 33 publications

High dietary salt intake correlates with modulated Th17-Treg cell balance resulting in enhanced bone loss and impaired bone-microarchitecture in male mice

High dietary salt intake correlates with modulated Th17-Treg cell balance resulting in enhanced bone loss and impaired bone-microarchitecture in male mice

Graphene Oxide Hybridized nHAC/PLGA Scaffolds Facilitate the Proliferation of MC3T3-E1 Cells

Poultry By-products as a Potential Source of Nutrients

Contact Info

Product

Resources

About