Bone destruction in chronic otitis media

Sadé, Jacob; Berco, E

doi:10.1017/s0022215100078889

Cited by 52 publications

(20 citation statements)

References 14 publications

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“…According to Gruber and Jackson, malleus and incus were involved equally in the disease [10,16] where as Schwatze, claimed malleus to be more often affected than incus [14]. Many authors like, Grippaudo, believe the stapes to be least commonly affected [11].…”

Section: Discussionmentioning

confidence: 99%

Histological and Histopathological Study of Incus

Sodhi

Chaudhary

Arora

2016

JCDR

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Section: Discussionmentioning

confidence: 99%

Histological and Histopathological Study of Incus

Sodhi

Chaudhary

Arora

2016

JCDR

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“…Ruedi 18 and Tumarkin 19 suggested that bone resorption would be due to the pressure placed by cholesteatomas on the ossicular surface. Thompsen et al 20 and Sadé & Berco 21 noticed that eroded ossicles were unvariably surrounded by an inflammatory reaction and they suggested that the inflammation was the cause of ossicular resorption. It has been proved that the granulation tissue adjacent to the ossicles is able to produce a variety of enzymes and mediators that accelerate ossicular resorption; they include lysosomic enzimes 22 , collagenases 23 and prostaglandins 24 .…”

Section: Discussionmentioning

confidence: 99%

“…1,2 They usually reach the ossicular chain and in a lesser extent the skull bones. Even the most rigid bone in the human body, the optic capsule, is affected, showing its strong destroying action on the bone tissue.…”

Section: Introductionmentioning

confidence: 99%

Correlação da cadeia ossicular no transoperatório com achados histológicos de colesteatomas

Dornelles

Rosito²,

Meurer³

et al. 2007

Rev. Bras. Otorrinolaringol.

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Chroni c otitis media is hystopathologycaly defined as the presence of irreversible inflammatory tissue changes in the middle ear. Ossicular lesions represent the most prevalent change. Aim: to correlate the degree of ossicular chain changes seen during surgery with the inflammatory histological degree and the thickness of the cholesteatoma perimatrix. Study design: Cross-sectional study. Methods: Seventyone descriptions of surgeries done in patients submitted to tympanomastoydectomy were reviewed. Cholesteatoma were collected and fixed in 10% formaldehyde. Two slides were made for each cholesteatoma, one stained with HE and another with picrossirius. Images were obtained from light microscopy and digitally processed and "blindly" analyzed using Image Pro-Plus Software. For statistical analysis we used Spearman's coefficient. Differences were considered statistically significant if P≤0.05. Results: the ossicular chain was involved in 65 cases. The incus was the most frequently affected bone, followed by the stapes and the malleus. When the Spearman's coefficient was employed considering ossicular chain change degree with patient's age by the time of surgery, perimatrix thickness and histological degree of inflammation, correlations were not established. Conclusion: Our findings indicate that ossicular chain changes are practically universal when a cholesteatoma is present. We didn't find correlations related with bone erosion and cholesteatoma's histological findings.

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“…12 Bone erosion associated with cholesteatomas is reported in 80%-96% of cases, with a higher incidence in children than in adults and in pars flaccida than in pars tensa cholesteatomas. [13][14][15] Congenital cholesteatomas cause ossicular erosion less frequently, to a lesser extent, and later in the course of the disease than acquired cholesteatomas.…”

Section: Histologymentioning

confidence: 99%

Neuroradiology of Cholesteatomas

Baráth¹,

Huber²,

Stämpfli³

et al. 2010

AJNR Am J Neuroradiol

181

141

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SUMMARY:The relevant aspects of cholesteatomas are reviewed with the emphasis on their diagnosis by using cross-sectional imaging. The indications and limitations of CT and MR imaging and the use of novel MR imaging techniques in the diagnosis of cholesteatomas are described. HRCT of the temporal bone has an excellent spatial resolution, thus even small soft-tissue lesions can be accurately delineated (high sensitivity). However, CT has poor specificity (ie, soft-tissue structures cannot be differentiated). MR imaging with the conventional sequences (T1WI, T2WI, postcontrast T1WI) provides additional information for distinguishing different pathologic entities and for accurately diagnosing primary (nonsurgical) and residual/recurrent (surgical) cholesteatomas. Higher diagnostic specificity is achieved by introducing DW-EPI, delayed postcontrast imaging, DW-non-EPI, and DWI-PROPELLER techniques. Studies using DW-non-EPI and DWI-PROPELLER sequences show promising results related to improved diagnostic sensitivity and specificity for even small (Ͻ5 mm) cholesteatomas, thus allowing avoidance of second-look surgery in the future.ABBREVIATIONS: DWI ϭ diffusion-weighted imaging; DW-EPI ϭ diffusion-weighted echo-planar imaging; DWI-PROPELLER ϭ diffusion-weighted imaging with periodically rotated overlapping parallel lines with enhanced reconstruction; DW-non-EPI ϭ diffusion-weighted non-echo-planar imaging; EAC ϭ external auditory canal; EACC ϭ external auditory canal cholesteatoma; EPI ϭ echo-planar imaging; FIESTA ϭ fast imaging employing steady-state acquisition; FLASH ϭ fast low-angle shot; HRCT ϭ high-resolution CT; NPV ϭ negative predictive value; PPV ϭ positive predictive value; T1WI ϭ T1-weighted imaging; T2WI ϭ T2-weighted imaging; TM ϭ tympanic membrane C holesteatoma has been known for more than 300 years in the medical literature; still its precise detection with the use of cross-sectional imaging techniques remains challenging. As before, the diagnosis of a cholesteatoma at first presentation is mainly based on clinical suspicion. HRCT provides information about bony changes and intracranial complications; however, it is inaccurate for characterizing the soft-tissue mass in the temporal bone. In the past 7 years, improvements in MR imaging techniques have enhanced the sensitivity and specificity of radiologic diagnosis, which may lead to future avoidance of second-look surgeries in cases of residual/recurrent cholesteatomas.The purpose of this review article is to summarize all aspects of cholesteatomas, including their definition, history, etymology, epidemiology, classification, histology, pathophysiology, clinical signs, and neuroradiologic diagnosis. We review the latest studies on the application of new MR imaging techniques for the accurate diagnosis of cholesteatomas. Definition"Cholesteatoma" is a well-demarcated non-neoplastic lesion in the temporal bone, which is commonly described as "skin in the wrong place." History and EtymologyJoseph-Guichard Duverney, a French anatomist, was the first to d...

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Bone destruction in chronic otitis media

Cited by 52 publications

References 14 publications

Histological and Histopathological Study of Incus

Histological and Histopathological Study of Incus

Correlação da cadeia ossicular no transoperatório com achados histológicos de colesteatomas

Neuroradiology of Cholesteatomas

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