Bone formation enhanced by implanted octacalcium phosphate involving conversion into Ca-deficient hydroxyapatite

Сузукі, Осаму; Kamakura, Shinji; Katagiri, Takenobu; Nakamura, Masanori; Zhao, Baohong; Honda, Yoshitomo; Kamijo, Ryutaro

doi:10.1016/j.biomaterials.2005.12.004

Cited by 326 publications

(396 citation statements)

References 38 publications

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“…The FTIR spectrum of the coating CaP (Fig. 3C) corresponded with that of HA reported previously 15) and also with that of Ca-deficient HA 16) . The bands originating from ν3 P-O in the orthophosphate stretch absorption around 1,100 cm -1 , sharp absorption bands of ν4 PO4 at 560-600 cm -1 and the band of carbonate around 1,600 cm -1 were identified, indicating that the coating is composed of HA phase containing carbonate.…”

Section: Cs-b Cs-d Cs-e Lmw Cs-e Cs-h Cps Andsupporting

confidence: 83%

Effect of chondroitin sulfate-E on the osteoclastic differentiation of RAW264 cells

Miyazaki

Miyauchi²,

Tawada³

et al. 2010

Dent. Mater. J.

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The present study was designed to investigate whether chondroitin sulfate (CS)-E, a CS structural isomer variant, alter the differentiation of macrophage cell line RAW264 cells to osteoclast-like cells. CS-B, CS-E, low molecular weight CS-E, synthetic chondroitin polysulfate (CPS) and heparin significantly inhibited the formation of tartrate-resistant acid phosphatase-positive multinuclear cells and pit formation on calcium phosphate (CaP)-coated plates. CS-E pre-coated on the CaP plate also inhibited pit formation. Digestion of CS on the cell surface by chondroitinase showed no effect on the osteoclastic differentiation of RAW264 cells whereas inhibitory effect on the differentiation of osteoblastic cell line MC3T3-E1. On the other hand, exogenously added fluoresceinlabeled CS-E directory bound to fibronectin and RAW264 cells. These results suggest that CS-E structure on the surface of osteoblasts or bone matrix binds to cell adhesion molecule such as integrin on the pre-osteoclastic cells and inhibits the differentiation into osteoclasts. CS-E may have a potential in treating bone defect if combined with CaP materials.

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Section: Cs-b Cs-d Cs-e Lmw Cs-e Cs-h Cps Andsupporting

confidence: 83%

Effect of chondroitin sulfate-E on the osteoclastic differentiation of RAW264 cells

Miyazaki

Miyauchi²,

Tawada³

et al. 2010

Dent. Mater. J.

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“…Although OCP/Col itself hardly showed radiopacity, it exhibited radiopacity by initiation of bone regeneration and the irreversible conversion from OCP to apatitic phase 27. Because it is quite difficult to distinguish newly formed bone and the converted apatite in radiographic examination,8, 9 it would be more suitable to apply histomorphometrical analysis of newly formed bone than radiomorphometric analysis by micro‐CT images.…”

Section: Methodsmentioning

confidence: 99%

Single‐dose local administration of teriparatide with a octacalcium phosphate collagen composite enhances bone regeneration in a rodent critical‐sized calvarial defect

et al. 2017

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Octacalcium phosphate and collagen composite (OCP/Col) achieves stable bone regeneration without cell transplantation in preclinical studies. Recently, a sponsor‐initiated clinical trial was conducted to commercialize the material. The present study investigated bone regeneration by OCP/Col with the single local administration of teriparatide (parathyroid hormone 1‐34; TPTD). OCP/Col was prepared by mixing sieved granules of OCP and atelocollagen for medical use and a disk was molded. After the creation of a rodent critical‐sized calvarial defect, OCP/Col or OCP/Col with dripped TPTD solution (1.0 or 0.1 µg; OCP/Col/TPTDd1.0 or OCP/Col/TPTDd0.1) was implanted into the defect. Six defects in each group were fixed 12 weeks after implantation. Radiographic examinations indicated that radiopaque figures in defects treated with OCP/Col with TPTD (OCP/Col/TPTDd) occupied a wider range than those treated with OCP/Col. Histological results demonstrated that most of the defect in OCP/Col/TPTDd was filled with newly formed bone. A histomorphometrical examination indicated that the percentage of newly formed bone was significantly higher in the defects of OCP/Col/TPTDd 1.0 (53.6 ± 4.3%) and OCP/Col/TPTDd 0.1 (52.2 ± 7.4%) than in those of OCP/Col (40.1 ± 8.4%), whereas no significant differences were observed between OCP/Col/TPTDd1.0 and OCP/Col/TPTDd0.1. These results suggest that OCP/Col with the single local administration of TPTD enhances bone regeneration in a rodent calvarial critical‐sized bone defect. © 2017 The Authors Journal of Biomedical Materials Research Part B: Applied Biomaterials Published by Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1851–1857, 2018.

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“…Although OCP has not been observed in vascular calcifications, it has been strongly suggested as a precursor phase to biological apatite found in natural and prosthetic heart valves (Tomazic et al 1994;Nancollas and Wu 2000). In surgery, OCP is used for implantation into bone defects (Suzuki et al 2006;Kikawa et al 2009;Murakami et al 2010;Suzuki 2013). For the comprehensive information on OCP, the readers are referred to other reviews (Suzuki 2010a;Chow and Eanes 2001;Suzuki 2013).…”

Section: Dcpa (Or Dcp)mentioning

confidence: 99%

Calcium orthophosphates (CaPO 4 ): Occurrence and properties

Dorozhkin¹

2017

Morphologie

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Bone formation enhanced by implanted octacalcium phosphate involving conversion into Ca-deficient hydroxyapatite

Cited by 326 publications

References 38 publications

Effect of chondroitin sulfate-E on the osteoclastic differentiation of RAW264 cells

Effect of chondroitin sulfate-E on the osteoclastic differentiation of RAW264 cells

Single‐dose local administration of teriparatide with a octacalcium phosphate collagen composite enhances bone regeneration in a rodent critical‐sized calvarial defect

Calcium orthophosphates (CaPO 4 ): Occurrence and properties

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