Bone formation in a cutaneous pyogenic granuloma

Fulton, R. A.; Smith, Gerald D.; Thomson, J.

doi:10.1111/j.1365-2133.1980.tb08153.x

Cited by 14 publications

(8 citation statements)

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“…We believe that this trauma may have influenced the development of capillary proliferation, and added inflammation or hypoxia may have induced BMP expression. In the reported cases of pyogenic granuloma with ossification, three of four cases did not mention lobular arrangements of capillary proliferation8,9,11. Therefore, there is a possibility that some of those cases may have actually been cases of acral angioosteoma cutis.…”

Section: Discussionmentioning

confidence: 99%

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Acral Angioosteoma Cutis

Lee

Shin

et al. 2011

Ann Dermatol

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Acral angioosteoma cutis is a rare disease first described in 2006 that is characterized by vascular proliferation with ossification at the acral area, and which bears clinical similarity to pyogenic granuloma. However, there is no lobular pattern in the capillary proliferation that is a typical histopathological feature in pyogenic granuloma. Metaplastic cutaneous ossification is associated with multiple skin diseases and inflammatory conditions such as scars, nevi, basal cell carcinomas, pilomatricomas, chondroid syringomas, and venous stasis. It is rarely associated with vascular proliferation diseases like hemangiomas and pyogenic granulomas. We report a case of capillary proliferation with ectopic bone formation in a 43-year-old female who presented with an ulcerative, dome-shaped subungual nodule on the left fourth toe, which appeared to be a pyogenic granuloma. Because the biopsy findings showed no lobular capillary proliferation, we determined that this case was consistent with acral angioosteoma cutis.

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Section: Discussionmentioning

confidence: 99%

“…However, the pathogenesis of metaplastic ossification has not been explored. There have been four documented cases of ectopic bone formation in cutaneous pyogenic granulomas to date8-11. Vascular endothelial growth factor (VEGF) and bone morphogenetic proteins (BMPs) may play a role in ectopic bone formation in pyogenic granuloma.…”

Section: Discussionmentioning

confidence: 99%

Acral Angioosteoma Cutis

Lee

Shin

et al. 2011

Ann Dermatol

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“…In addition to clinical similarity, AAOC could be misdiagnosed as PG with ossification because of the vascular and bony growth on histology. Of 4 reports of PG with ossification, only one commented on the lobular vascularity 5, 6, 7, 8. Kim et al 5 describes PG with ossification as lobular proliferation of capillaries with spicules of spongy bone with osteocytelike and osteoblastlike cells.…”

Section: Discussionmentioning

confidence: 99%

Recurrent acral angioosteoma cutis in a pregnant patient

et al. 2016

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“…We believe that this trauma may have influenced the development of capillary proliferation, and added inflammation or hypoxia may have induced BMP expression. In the reported cases of pyogenic granuloma with ossification, three of four cases did not mention lobular arrangements of capillary proliferation 8,9,11 . Therefore, there is a possibility that some of those cases may have actually been cases of acral angioosteoma cutis.…”

Section: Discussionmentioning

confidence: 99%

“…However, the pathogenesis of metaplastic ossification has not been explored. There have been four documented cases of ectopic bone formation in cutaneous pyogenic granulomas to date [8][9][10][11] . Vascular endothelial growth factor (VEGF) and bone morphogenetic proteins (BMPs) may play a role in ectopic bone formation in pyogenic granuloma.…”

Section: Discussionmentioning

confidence: 99%