Bone formation on carbon nanotube composite

Abstract

The effects of a layer-by-layer assembled carbon nanotube composite (CNT-comp) on osteoblasts in vitro and bone tissue in vivo in rats were studied. The effects of CNT-comp on osteoblasts were compared against the effects by commercially pure titanium (cpTi) and tissue culture dishes. Cell proliferation on the CNT-comp and cpTi were similar. However, cell differentiation, measured by alkaline phosphatase activity and matrix mineralization, was better on the CNT-comp. When implanted in critical-sized rat calvarial defect, the CNT-comp permitted bone formation and bone repair without signs of rejection or inflammation. These data indicate that CNT-comp may be a promising substrate for use as a bone implant or as a scaffold for tissue engineering.

Advances in bone repair with nanobiomaterials: mini-review

“…Both single-wall and multiwall carbon nanotubes were found to be able to interact with the biological tissues and to be useful for bone repair (Tutak et al 2009;Bhattacharya et al 2011;Joshi et al 2010;Mendes et al 2010;Niu et al 2010;Sahithi et al 2010;Tutak et al 2010). This has been well presented in the published literature and will not be further discussed here (see above references).…”

Graphene‐Based Materials in Regenerative Medicine

“…Another cell type is osteoblast which fi rst adheres on the extracellular matrix (ECM) surface to initiate bone formation, and then they spread and proliferate to cover the ECM surface. [ 117 ] Other cells include fi broblasts and sarcoma cells can also participate in bone regeneration. [ 118 ] …”

Electrical Stimulation of Myoblast Proliferation and Differentiation on Aligned Nanostructured Conductive Polymer Platforms

“…[ 9 ] More recently, platforms that incorporate micro and nanostructured conducting polymers (CPs) and carbon nanotubes (CNTs) for the guidance and stimulation of several cell types have been reported. [10][11][12][13][14] CPs are of particular interest because they provide the means to deliver biological agents while enabling simultaneous delivery of relevant electrical stimulation for modulating cell/tissue development. [ 15 , 16 ] In particular, polypyrrole (PPy) has been utilized in a number of in vitro studies investigating nerve, [ 17 ] muscle, [ 18 ] bone, [ 19 ] and endothelial cell growth.…”